{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T17:21:42Z","timestamp":1723051302429},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,7,27]],"date-time":"2011-07-27T00:00:00Z","timestamp":1311724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2011,8]]},"abstract":"Purpose:<\/jats:title>To perform a feasibility study of contrast\u2010enhanced whole brain radiotherapy for treating patients with multiple brain metastasis using a conventional computed tomography (CT) scanner.<\/jats:p><\/jats:sec>Methods:<\/jats:title>The treatment dose was optimized to be applied in a single run using a maximum tube power of kWs at kV. CT scans of a large and a small head were used as reference. Irradiation geometry, shielding, axial beam collimation, radial beam collimation, gantry tilt, and tube current for beam modulation were optimized using a Monte Carlo simulation and a contrast agent concentration of mg\/ml iodine in the tumor. The statistical uncertainty of the Monte Carlo simulation was corrected using back convolution.<\/jats:p><\/jats:sec>Results:<\/jats:title>Using a CT tube with a beam collimation of mm, a mean tumor dose of Gy was achieved, while the head bone dose was Gy with a normal brain dose of Gy, eye dose of Gy, and lens dose of Gy, respectively. Using a CT tube with dose modulation and a beam collimation of mm, the mean tumor dose was Gy with a head bone dose of Gy, normal brain dose of Gy, eye dose of Gy, and lens dose of Gy, respectively. Thus a standard CT scanner enables an effective tumor dose of Gy to be administered in 13 fractions, while exposing healthy brain to an effective dose of Gy and head bone to Gy. Additional radial collimation implemented in the hardware improves the therapeutic tumor dose by in relation to the bone dose.<\/jats:p><\/jats:sec>Conclusions:<\/jats:title>Contrast\u2010enhanced total brain radiotherapy is feasible using a conventional CT tube with optimized dose application.<\/jats:p><\/jats:sec>","DOI":"10.1118\/1.3609099","type":"journal-article","created":{"date-parts":[[2011,7,27]],"date-time":"2011-07-27T22:01:23Z","timestamp":1311804083000},"page":"4672-4680","source":"Crossref","is-referenced-by-count":11,"title":["Monte Carlo simulation of contrast\u2010enhanced whole brain radiotherapy on a CT scanner"],"prefix":"10.1002","volume":"38","author":[{"given":"Bernd\u2010Joachim","family":"Schultz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Wust","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutz","family":"L\u00fcdemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregor","family":"Jost","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hubertus","family":"Pietsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,7,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.594613"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2008.04.040"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00411\u2010004\u20100232\u20100"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031\u20109155\/55\/10\/R01"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167\u20108140(90)90034\u2010T"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360\u20103016(99)00347\u20108"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.1783552"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(80)90195-9"},{"key":"e_1_2_5_10_1","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/978-3-540-77385-6_44","volume-title":"Radiation oncology \u2010 An evidence\u2010based approach","author":"Gibbs I. 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