{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:13:51Z","timestamp":1753881231546,"version":"3.41.2"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,17]],"date-time":"2012-12-17T00:00:00Z","timestamp":1355702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":988,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21R33 CA 128407"],"award-info":[{"award-number":["R21R33 CA 128407"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21R33 CA 128407"],"award-info":[{"award-number":["R21R33 CA 128407"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aip.org"],"crossmark-restriction":true},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec><jats:title><jats:bold>Purpose:<\/jats:bold><\/jats:title><jats:p>Molecular breast imaging (MBI) is a dedicated nuclear medicine breast imaging modality that employs dual\u2010head cadmium zinc telluride (CZT) gamma cameras to functionally detect breast cancer. MBI has been shown to detect breast cancers otherwise occult on mammography and ultrasound. Currently, a MBI\u2010guided biopsy system does not exist to biopsy such lesions. Our objective was to consider the utility of a novel conical slant\u2010hole (CSH) collimator for rapid (&lt;1 min) and accurate monitoring of lesion position to serve as part of a MBI\u2010guided biopsy system.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:bold>Methods:<\/jats:bold><\/jats:title><jats:p>An initial CSH collimator design was derived from the dimensions of a parallel\u2010hole collimator optimized for MBI performed with dual\u2010head CZT gamma cameras. The parameters of the CSH collimator included the collimator height, cone slant angle, thickness of septa and cones of the collimator, and the annular areas exposed at the base of the cones. These parameters were varied within the geometric constraints of the MBI system to create several potential CSH collimator designs. The CSH collimator designs were evaluated using Monte Carlo simulations. The model included a breast compressed to a thickness of 6 cm with a 1\u2010cm diameter lesion located 3 cm from the collimator face. The number of particles simulated was chosen to represent the count density of a low\u2010dose, screening MBI study acquired with the parallel\u2010hole collimator for 10 min after a \u223c150 MBq (4 mCi) injection of Tc\u201099m sestamibi. The same number of particles was used for the CSH collimator simulations. In the resulting simulated images, the count sensitivity, spatial resolution, and accuracy of the lesion depth determined from the lesion profile width were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:bold>Results:<\/jats:bold><\/jats:title><jats:p>The CSH collimator design with default parameters derived from the optimal parallel\u2010hole collimator provided 1\u2010min images with error in the lesion depth estimation of 1.1 \u00b1 0.7 mm and over 21 times the lesion count sensitivity relative to 1\u2010min images acquired with the current parallel\u2010hole collimator. Sensitivity was increased via more vertical cone slant angles, larger annular areas, thinner cone walls, shorter cone heights, and thinner radiating septa. Full width at half maximum trended in the opposite direction as sensitivity for all parameters. There was less error in the depth estimates for less vertical slant angles, smaller annular areas, thinner cone walls, cone heights near 1 cm, and generally thinner radiating septa.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:bold>Conclusions:<\/jats:bold><\/jats:title><jats:p>A Monte Carlo model was used to demonstrate the feasibility of a CSH collimator design for rapid biopsy application in molecular breast imaging. Specifically, lesion depth of a 1\u2010cm diameter lesion positioned in the center of a typical breast can be estimated with error of less than 2 mm using circumferential count profiles of images acquired in 1 min.<\/jats:p><\/jats:sec>","DOI":"10.1118\/1.4770274","type":"journal-article","created":{"date-parts":[[2012,12,17]],"date-time":"2012-12-17T23:00:28Z","timestamp":1355785228000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["Collimator design for a dedicated molecular breast imaging\u2010guided biopsy system: Proof\u2010of\u2010concept"],"prefix":"10.1002","volume":"40","author":[{"given":"Amanda L.","family":"Weinmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carrie B.","family":"Hruska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy L.","family":"Conners","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael K.","family":"O'Connor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1075\u2010122X.2006.00269.x"},{"key":"e_1_2_7_3_1","first-page":"909","article-title":"High\u2010resolution scintimammography: A pilot study","volume":"43","author":"Brem R. F.","year":"2002","journal-title":"J. Nucl. Med."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524\u20104741.2006.00356.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10100625"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2011.3267"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2371040758"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10100454"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.10.6342"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010011\u20102054\u2010z"},{"key":"e_1_2_7_11_1","first-page":"2301","article-title":"Impact of diagnostic workup resulting from a positive low\u2010dose molecular breast imaging scan in a screening environment","volume":"52","author":"Pletta C.","year":"2011","journal-title":"J. Nucl. Med."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2541090953"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1109\/TNS.2006.876002"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003072\u2010200203000\u201000001"},{"key":"e_1_2_7_15_1","first-page":"553","article-title":"Scintimammography with dedicated breast camera detects and localizes occult carcinoma","volume":"45","author":"Coover L. R.","year":"2004","journal-title":"J. Nucl. Med."},{"key":"e_1_2_7_16_1","first-page":"1019","article-title":"Radionuclide\u2010guided stereotactic prebiopsy localization of nonpalpable breast lesions with normal mammograms","volume":"38","author":"Khalkhali I.","year":"1997","journal-title":"J. Nucl. Med."},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524\u20104741.2010.01044.x"},{"key":"e_1_2_7_18_1","first-page":"675","article-title":"Clinical use of a stereotactic breast\u2010specific gamma imaging apparatus in the localization of breast lesions for biopsy [abstract]","volume":"52","author":"Welch B. L.","year":"2011","journal-title":"J. Nucl. Med."},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.2885371"},{"key":"e_1_2_7_20_1","unstructured":"Los Alamos Monte Carlo Group MCNP\u2010 A General Monte Carlo N\u2010Particle Transport Code Version 5(Radiation Safety Information Computational Center at Oak Ridge National Laboratory (CCC\u2010740) 2003)."},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.3077119"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.3693"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1109\/TNS.2006.879824"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.4718665"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.4719959"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac60214a047"}],"container-title":["Medical Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1118%2F1.4770274","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1118%2F1.4770274","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/pdf\/10.1118\/1.4770274","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T12:36:26Z","timestamp":1695040586000},"score":1,"resource":{"primary":{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/10.1118\/1.4770274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,17]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1118\/1.4770274"],"URL":"https:\/\/doi.org\/10.1118\/1.4770274","archive":["Portico"],"relation":{},"ISSN":["0094-2405","2473-4209"],"issn-type":[{"type":"print","value":"0094-2405"},{"type":"electronic","value":"2473-4209"}],"subject":[],"published":{"date-parts":[[2012,12,17]]},"article-number":"012503"}}