{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:07:26Z","timestamp":1792177646898,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T00:00:00Z","timestamp":1358208000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T00:00:00Z","timestamp":1358208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":959,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P01CA021239"],"award-info":[{"award-number":["P01CA021239"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K25CA168984"],"award-info":[{"award-number":["K25CA168984"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007313","name":"University of Texas MD Anderson Cancer Center","doi-asserted-by":"publisher","award":["CA016672"],"award-info":[{"award-number":["CA016672"]}],"id":[{"id":"10.13039\/100007313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P01CA021239"],"award-info":[{"award-number":["P01CA021239"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K25CA168984"],"award-info":[{"award-number":["K25CA168984"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007313","name":"University of Texas MD Anderson Cancer Center","doi-asserted-by":"publisher","award":["CA016672"],"award-info":[{"award-number":["CA016672"]}],"id":[{"id":"10.13039\/100007313","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aip.org"],"crossmark-restriction":true},"short-container-title":["Med. Phys."],"published-print":{"date-parts":[[2013,1,15]]},"DOI":"10.1118\/1.4774363","type":"journal-article","created":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T18:00:34Z","timestamp":1358272834000},"page":"021709","update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":83,"title":["PTV-based IMPT optimization incorporating planning risk volumes vs robust optimization"],"prefix":"10.1002","volume":"40","author":[{"given":"Wei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Frank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yupeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron. X.","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhe","family":"Mohan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,15]]},"reference":[{"key":"10.1118\/1.4774363-BIB1|cit1","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.radonc.2006.07.025","article-title":"Intensity modulated photon and proton therapy for the treatment of head and neck tumors","volume":"80","author":"Steneker","year":"2006","journal-title":"Radiother. Oncol."},{"key":"10.1118\/1.4774363-BIB2|cit2","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.ijrobp.2008.05.065","article-title":"Intensity-modulated proton therapy versus helical tomotherapy in nasopharynx cancer: Planning comparison and NTCP evaluation","volume":"72","author":"Widesott","year":"2008","journal-title":"Int. J. Radiat. Oncol., Biol., Phys."},{"key":"10.1118\/1.4774363-BIB3|cit3","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1088\/0031-9155\/53\/4\/014","article-title":"Intensity modulated proton therapy and its sensitivity to treatment uncertainties 1: The potential effects of calculational uncertainties","volume":"53","author":"Lomax","year":"2008","journal-title":"Phys. Med. Biol."},{"key":"10.1118\/1.4774363-BIB4|cit4","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1088\/0031-9155\/53\/4\/015","article-title":"Intensity modulated proton therapy and its sensitivity to treatment uncertainties 2: The potential effects of inter-fraction and inter-field motions","volume":"53","author":"Lomax","year":"2008","journal-title":"Phys. Med. Biol."},{"key":"10.1118\/1.4774363-BIB5|cit5","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1078\/0939-3889-00217","article-title":"The clinical potential of intensity modulated proton therapy","volume":"14","author":"Lomax","year":"2004","journal-title":"Z. Med. Phys."},{"key":"10.1118\/1.4774363-BIB6|cit6","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.ijrobp.2009.07.1696","article-title":"Spot scanning proton beam therapy for prostate cancer: Treatment planning technique and analysis of consequence of rotational and translational alignment errors","volume":"78","author":"Meyer","year":"2010","journal-title":"Int. J. Radiat. Oncol., Biol., Phys."},{"key":"10.1118\/1.4774363-BIB7|cit7","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1118\/1.3021139","article-title":"Reducing the sensitivity of IMPT treatment plans to setup errors and range uncertainties via probabilistic treatment planning","volume":"36","author":"Unkelbach","year":"2009","journal-title":"Med. Phys."},{"key":"10.1118\/1.4774363-BIB8|cit8","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1088\/0031-9155\/53\/6\/013","article-title":"Worst case optimization: A method to account for uncertainties in the optimization of intensity modulated proton therapy","volume":"53","author":"Pflugfelder","year":"2008","journal-title":"Phys. Med. Biol."},{"key":"10.1118\/1.4774363-BIB9|cit9","doi-asserted-by":"publisher","first-page":"2755","DOI":"10.1088\/0031-9155\/52\/10\/009","article-title":"Accounting for range uncertainties in the optimization of intensity modulated proton therapy","volume":"52","author":"Unkelbach","year":"2007","journal-title":"Phys. Med. Biol."},{"key":"10.1118\/1.4774363-BIB10|cit10","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1088\/0031-9155\/57\/3\/591","article-title":"Including robustness in multi-criteria optimization for intensity-modulated proton therapy","volume":"57","author":"Chen","year":"2012","journal-title":"Phys. Med. Biol."},{"key":"10.1118\/1.4774363-BIB11|cit11","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1118\/1.3556559","article-title":"Minimax optimization for handling range and setup uncertainties in proton therapy","volume":"38","author":"Fredriksson","year":"2011","journal-title":"Med. Phys."},{"key":"10.1118\/1.4774363-BIB12|cit12","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.radonc.2012.03.017","article-title":"Potentials of robust intensity modulated scanning proton plans for locally advanced lung cancer in comparison to intensity modulated photon plans","volume":"104","author":"Stuschke","year":"2012","journal-title":"Radiother. Oncol."},{"key":"10.1118\/1.4774363-BIB13|cit13","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1118\/1.2191016","article-title":"Inverse plan optimization accounting for random geometric uncertainties with a multiple instance geometry approximation (MIGA)","volume":"33","author":"McShan","year":"2006","journal-title":"Med. Phys."},{"key":"10.1118\/1.4774363-BIB14|cit14","doi-asserted-by":"publisher","first-page":"3089","DOI":"10.1118\/1.4711909","article-title":"Influence of robust optimization in intensity-modulated proton therapy with different dose delivery techniques","volume":"39","author":"Liu","year":"2012","journal-title":"Med. Phys."},{"key":"10.1118\/1.4774363-BIB15|cit15","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1118\/1.3679340","article-title":"Robust optimization in intensity-modulated proton therapy","volume":"39","author":"Liu","year":"2012","journal-title":"Med. Phys."},{"key":"10.1118\/1.4774363-BIB16|cit16","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/S0167-8140(02)00015-4","article-title":"Margins for geometric uncertainty around organs at risk in radiotherapy","volume":"62","author":"McKenzie","year":"2002","journal-title":"Radiother. Oncol."},{"key":"10.1118\/1.4774363-BIB17|cit17","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1007\/978-3-642-03474-9_253","article-title":"Setup and dose calculation errors in IMPT and their interrelation","volume":"25","author":"Unkelbach","year":"2009","journal-title":"World Congr. Med. Phys. Biomed. Eng."},{"key":"10.1118\/1.4774363-BIB18|cit18","doi-asserted-by":"publisher","first-page":"S133","DOI":"10.1016\/j.ijrobp.2010.07.334","article-title":"Evaluation of dosimetric gain and uncertainties in proton therapy delivery with scanned pencil beam in treatment of base-of-skull and spinal Tumors","volume":"78","author":"Trofimov","year":"2010","journal-title":"Int. J. Radiat. Oncol., Biol., Phys."},{"key":"10.1118\/1.4774363-BIB19|cit19","doi-asserted-by":"publisher","first-page":"2863","DOI":"10.1088\/0031-9155\/55\/10\/005","article-title":"The influence of the optimization starting conditions on the robustness of intensity-modulated proton therapy plans","volume":"55","author":"Albertini","year":"2010","journal-title":"Phys. Med. Biol."},{"key":"10.1118\/1.4774363-BIB20|cit20","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.prro.2011.08.001","article-title":"Visualization of a variety of possible dosimetric outcomes in radiation therapy using dose-volume histogram bands","volume":"2","author":"Trofimov","year":"2012","journal-title":"Prac. Radiat. Oncol."},{"key":"10.1118\/1.4774363-BIB21|cit21","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1118\/1.1350587","article-title":"Intensity modulated proton therapy: A clinical example","volume":"28","author":"Lomax","year":"2001","journal-title":"Med. Phys."},{"key":"10.1118\/1.4774363-BIB22|cit22","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1140\/epjp\/i2011-11067-y","article-title":"Treatment planning in proton therapy","volume":"126","author":"Schwarz","year":"2011","journal-title":"Eur. Phys. J. Plus"},{"key":"10.1118\/1.4774363-BIB23|cit23","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1227\/01.NEU.0000143330.30405.AA","article-title":"Radiotherapeutic factors in the management of cervical-basal chordomas and chondrosarcomas","volume":"55","author":"Noel","year":"2004","journal-title":"Neurosurgery"},{"key":"10.1118\/1.4774363-BIB24|cit24","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/S0360-3016(97)00364-7","article-title":"Brainstem tolerance to conformal radiotherapy of skull base tumors","volume":"39","author":"Debus","year":"1997","journal-title":"Int. J. Radiat. Oncol., Biol., Phys."}],"container-title":["Medical Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1118%2F1.4774363","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1118%2F1.4774363","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1118\/1.4774363\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T05:55:41Z","timestamp":1562565341000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1118\/1.4774363"}},"subtitle":["PTV+PRV-based optimization vs robust optimization"],"short-title":[],"issued":{"date-parts":[[2013,1,15]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"URL":"https:\/\/doi.org\/10.1118\/1.4774363","archive":["Portico"],"relation":{},"ISSN":["0094-2405"],"issn-type":[{"value":"0094-2405","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1,15]]},"assertion":[{"value":"2012-06-14","order":0,"name":"received","label":"received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-11-29","order":1,"name":"revised","label":"revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-12-20","order":2,"name":"accepted","label":"accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-01-15","order":6,"name":"published","label":"published","group":{"name":"publication_history","label":"Publication History"}}]}}