{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:59:09Z","timestamp":1788872349020,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T00:00:00Z","timestamp":1416787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":281,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003958","name":"Technologiestichting STW (Technology Foundation STW)","doi-asserted-by":"publisher","award":["10846"],"award-info":[{"award-number":["10846"]}],"id":[{"id":"10.13039\/501100003958","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Technologiestichting STW (Technology Foundation STW)","award":["10846"],"award-info":[{"award-number":["10846"]}]}],"content-domain":{"domain":["aip.org"],"crossmark-restriction":true},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>In current clinical practice, head and neck (H&amp;N) hyperthermia treatment planning (HTP) is solely based on computed tomography (CT) images. Magnetic resonance imaging (MRI) provides superior soft\u2010tissue contrast over CT. The purpose of the authors\u2019 study is to investigate the relevance of using MRI in addition to CT for patient modeling in H&amp;N HTP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      CT and MRI scans were acquired for 11 patients in an immobilization mask. Three observers manually segmented on CT, MRI T1 weighted (MRI\u2010T1w), and MRI T2 weighted (MRI\u2010T2w) images the following thermo\u2010sensitive tissues: cerebrum, cerebellum, brainstem, myelum, sclera, lens, vitreous humor, and the optical nerve. For these tissues that are used for patient modeling in H&amp;N HTP, the interobserver variation of manual tissue segmentation in CT and MRI was quantified with the mean surface distance (MSD). Next, the authors compared the impact of CT and CT and MRI based patient models on the predicted temperatures. For each tissue, the modality was selected that led to the lowest observer variation and inserted this in the combined CT and MRI based patient model (CT and MRI), after a deformable image registration. In addition, a patient model with a detailed segmentation of brain tissues (including white matter, gray matter, and cerebrospinal fluid) was created (CT and MRI\n                      <jats:sub>db<\/jats:sub>\n                      ). To quantify the relevance of MRI based segmentation for H&amp;N HTP, the authors compared the predicted maximum temperatures in the segmented tissues (\n                      <jats:italic>T<\/jats:italic>\n                      <jats:sub>max<\/jats:sub>\n                      ) and the corresponding specific absorption rate (SAR) of the patient models based on (1) CT, (2) CT and MRI, and (3) CT and MRI\n                      <jats:sub>db<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In MRI, a similar or reduced interobserver variation was found compared to CT (maximum of median MSD in CT: 0.93 mm, MRI\u2010T1w: 0.72 mm, MRI\u2010T2w: 0.66 mm). Only for the optical nerve the interobserver variation is significantly lower in CT compared to MRI (median MSD in CT: 0.58 mm, MRI\u2010T1w: 1.27 mm, MRI\u2010T2w: 1.40 mm). Patient models based on CT (\n                      <jats:italic>T<\/jats:italic>\n                      <jats:sub>max<\/jats:sub>\n                      : 38.0\u2009\u00b0C) and CT and MRI (\n                      <jats:italic>T<\/jats:italic>\n                      <jats:sub>max<\/jats:sub>\n                      : 38.1\u2009\u00b0C) result in similar simulated temperatures, while CT and MRI\n                      <jats:sub>db<\/jats:sub>\n                      (\n                      <jats:italic>T<\/jats:italic>\n                      <jats:sub>max<\/jats:sub>\n                      : 38.5\u2009\u00b0C) resulted in significantly higher temperatures. The SAR corresponding to these temperatures did not differ significantly.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Although MR imaging reduces the interobserver variation in most tissues, it does not affect simulated local tissue temperatures. However, the improved soft\u2010tissue contrast provided by MRI allows generating a detailed brain segmentation, which has a strong impact on the predicted local temperatures and hence may improve simulation guided hyperthermia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1118\/1.4901270","type":"journal-article","created":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T20:31:04Z","timestamp":1416861064000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":22,"title":["The relevance of MRI for patient modeling in head and neck hyperthermia treatment planning: A comparison of CT and CT\u2010MRI based tissue segmentation on simulated temperature"],"prefix":"10.1002","volume":"41","author":[{"given":"Ren\u00e9 F.","family":"Verhaart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Fortunati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerda M.","family":"Verduijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aad","family":"van der Lugt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo","family":"van Walsum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jifke F.","family":"Veenland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarethus M.","family":"Paulides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(00)02059\u20106"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.07.2348"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.520"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167\u20108140(97)00134\u20105"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/02656730903418283"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/02656736.2010.503982"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/02656730701670478"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031\u20109155\/55\/9\/003"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/02656736.2013.783934"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00066\u2010014\u20100709\u2010y"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.4810971"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2014.01.027"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/02656730500070102"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031\u20109155\/54\/7\/019"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031\u20109155\/59\/9\/2139"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360\u20103016(03)00570\u20104"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748\u2010717X\u20105\u201021"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2009.12.021"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.05.060"},{"issue":"6","key":"e_1_2_7_21_1","first-page":"1092","article-title":"Intraobserver variability in the MR determination of tumor volume in squamous cell carcinoma of the pharynx","volume":"25","author":"Gordon A. 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