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high\u2010resolution image from multiple thick\u2010slice scans has been investigated through techniques in frequency, image, and wavelet domains. Experiments were carried out with thick\u2010slice T2\u2010weighted fast spin echo sequence on the Academic College of Radiology MRI phantom, where the reconstructed images were compared to a reference high\u2010resolution scan using peak signal\u2010to\u2010noise ratio (PSNR), structural similarity image metric (SSIM), mutual information (MI), and the mean absolute error (MAE) of image intensity profiles. The application of super\u2010resolution reconstruction was then examined in retrospective processing of clinical neuroimages of ten pediatric patients with tuberous sclerosis complex (TSC) to reduce through\u2010plane partial voluming for improved 3D delineation and visualization of thin radial bands of white matter abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Quantitative evaluation results show improvements in all evaluation metrics through super\u2010resolution reconstruction in the frequency, image, and wavelet domains, with the highest values obtained from SRR in the image domain. The metric values for image\u2010domain SRR versus the original axial, coronal, and sagittal images were PSNR = 32.26 vs 32.22, 32.16, 30.65; SSIM\u2009=\u20090.931 vs 0.922, 0.924, 0.918; MI\u2009=\u20090.871 vs 0.842, 0.844, 0.831; and MAE\u2009=\u20095.38 vs 7.34, 7.06, 6.19. All similarity metrics showed high correlations with expert ranking of image resolution with MI showing the highest correlation at 0.943. Qualitative assessment of the neuroimages of ten TSC patients through in\u2010plane and out\u2010of\u2010plane visualization of structures showed the extent of partial voluming effect in a real clinical scenario and its reduction using SRR. Blinded expert evaluation of image resolution in resampled out\u2010of\u2010plane views consistently showed the superiority of SRR compared to original axial and coronal image acquisitions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Thick\u2010slice 2D T2\u2010weighted MRI scans are part of many routine clinical protocols due to their high signal\u2010to\u2010noise ratio, but are often severely affected by through\u2010plane partial voluming effects. This study shows that while radiologic assessment is performed in 2D on thick\u2010slice scans, super\u2010resolution MRI reconstruction techniques can be used to fuse those scans to generate a high\u2010resolution image with reduced partial voluming for improved postacquisition processing. Qualitative and quantitative evaluation showed the efficacy of all SRR techniques with the best results obtained from SRR in the image domain. The limitations of SRR techniques are uncertainties in modeling the slice profile, density compensation, quantization in resampling, and uncompensated motion between scans.<\/jats:p><\/jats:sec>","DOI":"10.1118\/1.4935149","type":"journal-article","created":{"date-parts":[[2015,11,11]],"date-time":"2015-11-11T18:50:55Z","timestamp":1447267855000},"page":"6919-6932","update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":30,"title":["Super\u2010resolution reconstruction in frequency, image, and wavelet domains to reduce through\u2010plane partial voluming in MRI"],"prefix":"10.1002","volume":"42","author":[{"given":"Ali","family":"Gholipour","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onur","family":"Afacan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iman","family":"Aganj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benoit","family":"Scherrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay P.","family":"Prabhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7659-3880","authenticated-orcid":false,"given":"Simon K.","family":"Warfield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,30]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Magnetic Resonance Imaging: Physical Principles and Sequence Design","author":"Haacke E. 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