{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:37:54Z","timestamp":1790667474756,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T00:00:00Z","timestamp":1450310400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T00:00:00Z","timestamp":1450310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001171","name":"Cancer Institute NSW","doi-asserted-by":"publisher","award":["13-ECF-1\/15"],"award-info":[{"award-number":["13-ECF-1\/15"]}],"id":[{"id":"10.13039\/501100001171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001111","name":"Cancer Australia","doi-asserted-by":"publisher","award":["APP1060919"],"award-info":[{"award-number":["APP1060919"]}],"id":[{"id":"10.13039\/501100001111","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001171","name":"Cancer Institute NSW","doi-asserted-by":"publisher","award":["13-ECF-1\/15"],"award-info":[{"award-number":["13-ECF-1\/15"]}],"id":[{"id":"10.13039\/501100001171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001111","name":"Cancer Australia","doi-asserted-by":"publisher","award":["APP1060919"],"award-info":[{"award-number":["APP1060919"]}],"id":[{"id":"10.13039\/501100001111","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001171","name":"Cancer Institute NSW","doi-asserted-by":"publisher","award":["13-ECF-1\/15"],"award-info":[{"award-number":["13-ECF-1\/15"]}],"id":[{"id":"10.13039\/501100001171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001111","name":"Cancer Australia","doi-asserted-by":"publisher","award":["APP1060919"],"award-info":[{"award-number":["APP1060919"]}],"id":[{"id":"10.13039\/501100001111","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aip.org"],"crossmark-restriction":true},"short-container-title":["Med. Phys."],"published-print":{"date-parts":[[2015,12,17]]},"DOI":"10.1118\/1.4937599","type":"journal-article","created":{"date-parts":[[2015,12,18]],"date-time":"2015-12-18T21:50:17Z","timestamp":1450475417000},"page":"33-43","update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":57,"title":["Estimating lung ventilation directly from 4D CT Hounsfield unit values"],"prefix":"10.1002","volume":"43","author":[{"given":"John","family":"Kipritidis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Hofman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shankar","family":"Siva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Callahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Yves","family":"Le Roux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry C.","family":"Woodruff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William B.","family":"Counter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Keall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,17]]},"reference":[{"key":"10.1118\/1.4937599-BIB1|mp7599-cit-c1","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.ijrobp.2010.02.008","article-title":"Impact of four-dimensional computed tomography pulmonary ventilation imaging-based functional avoidance for lung cancer radiotherapy","volume":"79","author":"Yamamoto","year":"2011","journal-title":"Int. J. Radiat. Oncol., Biol., Phys."},{"key":"10.1118\/1.4937599-BIB2|mp7599-cit-c2","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.ijrobp.2012.04.043","article-title":"Predicting radiation pneumonitis after chemoradiation therapy for lung cancer: An international individual patient data meta-analysis","volume":"85","author":"Palma","year":"2013","journal-title":"Int. J. Radiat. Oncol., Biol., Phys."},{"key":"10.1118\/1.4937599-BIB3|mp7599-cit-c3","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1088\/0031-9155\/51\/4\/002","article-title":"Dynamic ventilation imaging from four-dimensional computed tomography","volume":"51","author":"Guerrero","year":"2006","journal-title":"Phys. Med. Biol."},{"key":"10.1118\/1.4937599-BIB4|mp7599-cit-c4","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/j.media.2008.03.007","article-title":"Registration-based estimates of local lung tissue expansion compared to xenon CT measures of specific ventilation","volume":"12","author":"Reinhardt","year":"2008","journal-title":"Med. Image Anal."},{"key":"10.1118\/1.4937599-BIB5|mp7599-cit-c5","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/BF02988614","article-title":"Technical and analytical advances in pulmonary ventilation SPECT with xenon-133 gas and Tc-99m-Technegas","volume":"16","author":"Suga","year":"2002","journal-title":"Ann. Nucl. Med."},{"key":"10.1118\/1.4937599-BIB6|mp7599-cit-c6","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s00259-013-2607-4","article-title":"High-resolution imaging of pulmonary ventilation and perfusion with Ga-VQ respiratory gated (4-D) PET\/CT","volume":"41","author":"Callahan","year":"2013","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1118\/1.4937599-BIB7|mp7599-cit-c7","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1016\/j.acra.2012.08.007","article-title":"Hyperpolarized 3He magnetic resonance imaging: Comparison with four-dimensional x-ray computed tomography imaging in lung cancer","volume":"19","author":"Mathew","year":"2012","journal-title":"Acad. Radiol."},{"key":"10.1118\/1.4937599-BIB8|mp7599-cit-c8","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1186\/1471-2407-14-740","article-title":"A prospective observational study of Gallium-68 ventilation and perfusion PET\/CT during and after radiotherapy in patients with non-small cell lung cancer","volume":"14","author":"Siva","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1118\/1.4937599-BIB9|mp7599-cit-c9","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1186\/1471-2407-14-934","article-title":"Functional lung avoidance for individualized radiotherapy (FLAIR): Study protocol for a randomized, double-blind clinical trial","volume":"14","author":"Hoover","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1118\/1.4937599-BIB10|mp7599-cit-c10","doi-asserted-by":"publisher","first-page":"5084","DOI":"10.1118\/1.4736808","article-title":"Comparison of image registration based measures of regional lung ventilation from dynamic spiral CT with Xe-CT","volume":"39","author":"Ding","year":"2012","journal-title":"Med. Phys."},{"key":"10.1118\/1.4937599-BIB11|mp7599-cit-c11","doi-asserted-by":"publisher","first-page":"135","DOI":"10.3109\/01902148.2014.984085","article-title":"Comparison of CT-derived ventilation maps with deposition patterns of inhaled microspheres in rats","volume":"41","author":"Jacob","year":"2014","journal-title":"Exp. Lung Res."},{"key":"10.1118\/1.4937599-BIB12|mp7599-cit-c12","doi-asserted-by":"publisher","first-page":"101907","DOI":"10.1118\/1.4820538","article-title":"4D CT lung ventilation images are affected by the 4D CT sorting method","volume":"40","author":"Yamamoto","year":"2013","journal-title":"Med. Phys."},{"key":"10.1118\/1.4937599-BIB13|mp7599-cit-c13","doi-asserted-by":"publisher","first-page":"011910","DOI":"10.1118\/1.4856055","article-title":"Validating and improving CT ventilation imaging by correlating with ventilation 4D-PET\/CT using 68Ga-labeled nanoparticles","volume":"41","author":"Kipritidis","year":"2014","journal-title":"Med. Phys."},{"key":"10.1118\/1.4937599-BIB14|mp7599-cit-c14","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1016\/j.ijrobp.2008.06.1937","article-title":"Retrospective analysis of artifacts in four-dimensional CT images of 50 abdominal and thoracic radiotherapy patients","volume":"72","author":"Yamamoto","year":"2008","journal-title":"Int. J. Radiat. Oncol., Biol., Phys."},{"key":"10.1118\/1.4937599-BIB15|mp7599-cit-c15","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1118\/1.3547719","article-title":"Four-dimensional computed tomography pulmonary ventilation images vary with deformable image registration algorithms and metrics","volume":"38","author":"Yamamoto","year":"2011","journal-title":"Med. Phys."},{"key":"10.1118\/1.4937599-BIB16|mp7599-cit-c16","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1118\/1.4907991","article-title":"Measuring interfraction and intrafraction lung function changes during radiation therapy using four-dimensional cone beam CT ventilation imaging","volume":"42","author":"Kipritidis","year":"2015","journal-title":"Med. Phys."},{"key":"10.1118\/1.4937599-BIB17|mp7599-cit-c17","doi-asserted-by":"publisher","first-page":"123504","DOI":"10.1118\/1.4829519","article-title":"Respiratory effort correction strategies to improve the reproducibility of lung expansion measurements","volume":"40","author":"Du","year":"2013","journal-title":"Med. Phys."},{"key":"10.1118\/1.4937599-BIB18|mp7599-cit-c18","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/1471-2342-14-25","article-title":"Determination of regional lung air volume distribution at mid-tidal breathing from computed tomography: A retrospective study of normal variability and reproducibility","volume":"14","author":"Fleming","year":"2014","journal-title":"BMC Med. Imaging"},{"key":"10.1118\/1.4937599-BIB19|mp7599-cit-c19","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1023\/A:1011444826908","article-title":"Non-invasive imaging of regional lung function using x-ray computed tomography","volume":"16","author":"Simon","year":"2000","journal-title":"J. Clin. Monit. Comput."},{"key":"10.1118\/1.4937599-BIB20|mp7599-cit-c20","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1164\/ajrccm.159.5.9805112","article-title":"A scanographic assessment of pulmonary morphology in acute lung injury. Significance of the lower inflection point detected on the lung pressure-volume curve","volume":"159","author":"Vieira","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1118\/1.4937599-BIB21|mp7599-cit-c21","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1007\/s001340051340","article-title":"Regional distribution of gas and tissue in acute respiratory distress syndrome. III. Consequences for the effects of positive end-expiratory pressure","volume":"26","author":"Puybasset","year":"2000","journal-title":"Intensive Care Med."},{"key":"10.1118\/1.4937599-BIB22|mp7599-cit-c22","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.ijrobp.2015.06.005","article-title":"Ventilation\/perfusion positron emission tomography-Based assessment of radiation injury to lung","volume":"93","author":"Siva","year":"2015","journal-title":"Int. J. Radiat. Oncol., Biol., Phys."},{"key":"10.1118\/1.4937599-BIB23|mp7599-cit-c23","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.radonc.2011.08.012","article-title":"Radiation dose response of normal lung assessed by cone beam CT-A potential tool for biologically adaptive radiation therapy","volume":"100","author":"Bertelsen","year":"2011","journal-title":"Radiother. Oncol."},{"key":"10.1118\/1.4937599-BIB24|mp7599-cit-c24","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1016\/j.ijrobp.2014.11.030","article-title":"Lung texture in serial thoracic computed tomography scans: Correlation of radiomics-based features with radiation therapy dose and radiation pneumonitis development","volume":"91","author":"Cunliffe","year":"2015","journal-title":"Int. J. Radiat. Oncol., Biol., Phys."},{"key":"10.1118\/1.4937599-BIB25|mp7599-cit-c25","doi-asserted-by":"publisher","DOI":"10.1177\/1533034614565534","article-title":"Ga-68 MAA perfusion 4D-PET\/CT scanning allows for functional lung avoidance using conformal radiation therapy planning","author":"Siva","year":"2015","journal-title":"Technol. Cancer Res. Treat."},{"key":"10.1118\/1.4937599-BIB26|mp7599-cit-c26","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.ijrobp.2014.06.006","article-title":"Pulmonary ventilation imaging based on 4-dimensional computed tomography: Comparison with pulmonary function tests and SPECT ventilation images","volume":"90","author":"Yamamoto","year":"2014","journal-title":"Int. J. Radiat. Oncol., Biol., Phys."},{"key":"10.1118\/1.4937599-BIB27|mp7599-cit-c27","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezv276","article-title":"Measurement of preoperative lobar lung function with computed tomography ventilation imaging: Progress towards rapid stratification of lung cancer lobectomy patients with abnormal lung function","author":"Eslick","year":"2015","journal-title":"Eur. J. Cardio-Thorac. Surg."},{"key":"10.1118\/1.4937599-BIB28|mp7599-cit-c28","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1118\/1.3668056","article-title":"Use of weekly 4DCT-based ventilation maps to quantify changes in lung function for patients undergoing radiation therapy","volume":"39","author":"Vinogradskiy","year":"2012","journal-title":"Med. Phys."},{"key":"10.1118\/1.4937599-BIB29|mp7599-cit-c29","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.ijrobp.2014.01.044","article-title":"Changes in functional lung regions during the course of radiation therapy and their potential impact on lung dosimetry for non-small cell lung cancer","volume":"89","author":"Meng","year":"2014","journal-title":"Int. J. Radiat. Oncol., Biol., Phys."},{"key":"10.1118\/1.4937599-BIB30|mp7599-cit-c30","doi-asserted-by":"publisher","first-page":"7387","DOI":"10.1088\/0031-9155\/60\/18\/7387","article-title":"Improved correction for the tissue fraction effect in lung PET\/CT imaging","volume":"60","author":"Holman","year":"2015","journal-title":"Phys. Med. Biol."},{"key":"10.1118\/1.4937599-BIB31|mp7599-cit-c31","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1109\/TMI.2009.2035616","article-title":"Elastix: A toolbox for intensity-based medical image registration","volume":"29","author":"Klein","year":"2010","journal-title":"IEEE Trans. Med. Imaging"}],"container-title":["Medical Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1118%2F1.4937599","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1118%2F1.4937599","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1118\/1.4937599\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T07:28:10Z","timestamp":1490599690000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1118\/1.4937599"}},"subtitle":["Estimating lung ventilation from 4DCT HU values"],"short-title":[],"issued":{"date-parts":[[2015,12,17]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"URL":"https:\/\/doi.org\/10.1118\/1.4937599","archive":["Portico"],"relation":{},"ISSN":["0094-2405"],"issn-type":[{"value":"0094-2405","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12,17]]},"assertion":[{"value":"2015-07-02","order":0,"name":"received","label":"received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-10-07","order":1,"name":"revised","label":"revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-11-16","order":2,"name":"accepted","label":"accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-12-17","order":6,"name":"published","label":"published","group":{"name":"publication_history","label":"Publication History"}}]}}