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First, a retrospective study analyzed DCE\u2010MRI data previously acquired on different patients using NFS (<jats:italic>n<\/jats:italic> = 18) or FS (<jats:italic>n<\/jats:italic> = 18) scans. Second, a phantom study simulated the signal enhancements in the presence of gadolinium contrast agent at six concentrations and three fat contents. Finally, a prospective study recruited nine healthy volunteers to investigate the influence of fat suppression on perfusion quantification on the same subjects. Parotid perfusion parameters were derived from NFS and FS DCE\u2010MRI data using both pharmacokinetic model analysis and semiquantitative parametric analysis. <jats:italic>T<\/jats:italic> tests and linear regression analysis were used for statistical analysis with correction for multiple comparisons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>NFS scans showed lower amplitude\u2010related parameters, including parameter <jats:italic>A<\/jats:italic>, peak enhancement (PE), and slope than FS scans in the patients (all with <jats:italic>P<\/jats:italic> &lt; 0.0167). The relative signal enhancement in the phantoms was proportional to the dose of contrast agent and was lower in NFS scans than in FS scans. The volunteer study showed lower parameter <jats:italic>A<\/jats:italic> (6.75 \u00b1 2.38 a.u.), PE (42.12% \u00b1 14.87%), and slope (1.43% \u00b1 0.54% s<jats:sup>\u22121<\/jats:sup>) in NFS scans as compared to 17.63 \u00b1 8.56 a.u., 104.22% \u00b1 25.15%, and 9.68% \u00b1 1.67% s<jats:sup>\u22121<\/jats:sup>, respectively, in FS scans (all with <jats:italic>P<\/jats:italic> &lt; 0.005). These amplitude\u2010related parameters were negatively associated with the fat content in NFS scans only (all with <jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>On NFS DCE\u2010MRI, quantification of parotid perfusion is adversely affected by the presence of fat signals for all amplitude\u2010related parameters. The influence could be reduced on FS scans.<\/jats:p><\/jats:sec>","DOI":"10.1118\/1.4943798","type":"journal-article","created":{"date-parts":[[2016,3,23]],"date-time":"2016-03-23T17:59:48Z","timestamp":1458755988000},"page":"1873-1881","update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["Influence of amplitude\u2010related perfusion parameters in the parotid glands by non\u2010fat\u2010saturated dynamic contrast\u2010enhanced magnetic resonance imaging"],"prefix":"10.1002","volume":"43","author":[{"given":"Su\u2010Chin","family":"Chiu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng\u2010Chieh","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hing\u2010Chiu","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiao\u2010Wen","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui\u2010Chu","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Jui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsian\u2010He","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Jung","family":"Juan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2262011486"},{"key":"e_1_2_7_3_1","first-page":"1256","article-title":"Warthin tumor of the parotid gland: Diagnostic value of MR imaging with histopathologic correlation","volume":"25","author":"Ikeda M.","year":"2004","journal-title":"Am. 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