{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:59:18Z","timestamp":1791125958468,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[1998,11,13]],"date-time":"1998-11-13T00:00:00Z","timestamp":910915200000},"content-version":"vor","delay-in-days":43,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[1998,10]]},"abstract":"<jats:p>The measurement of bone microstructure as well as bone mineral density may improve the estimation of bone strength. Cubic specimens (<jats:italic>N<\/jats:italic>=26, 12 mm\u00d712 mm\u00d712 mm) of human cadaver vertebrae were cut along three orthogonal anatomic orientations, i.e., superior\u2013inferior (SI), medial\u2013lateral (ML), and anterior\u2013posterior (AP). Contact radiographs of the bone cubes along all three orientations were obtained and then digitized by a laser scanner with pixel size of 50 \u03bcm\u00d750 \u03bcm. The specimens were tested in compression along the 3 orthogonal orientations and the Young's modulus (YM) was calculated for each direction. Quantitative computed tomography (QCT) was used to obtain a measure of trabecular bone mineral density (BMD). Global gray level thresholding and local thresholding algorithms were used to extract the trabecular bone network. Apparent trabecular bone fraction (ABV\/TV), mean intercept length (I.TH), mean intercept separation (I.SP), and number of nodes (N.ND) were measured from the extracted trabecular network. Fractal dimension (Fr.D) of the trabecular bone texture was also measured. Paired <jats:italic>t<\/jats:italic>\u2010tests showed that the mean values of each texture parameter (except ABV\/TV) and of YM along the SI direction were significantly different <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mp8391-math-0001.png\" xlink:title=\"urn:x-wiley:00942405:media:mp8391:mp8391-math-0001\"\/> from those along the ML and AP direction. However, the mean values along the ML and AP directions were not significantly different. Multivariate regression of YM as a function of the texture parameters and BMD showed that without adjusting for the effect of BMD, YM was significantly explained by all the texture parameters <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mp8391-math-0002.png\" xlink:title=\"urn:x-wiley:00942405:media:mp8391:mp8391-math-0002\"\/> When BMD was included in the regression, although the variations in YM of ML, AP, and SI orientations could be explained by BMD alone, some of the texture parameters did improve the overall prediction of the biomechanical properties, while, some parameters such as ABV\/TV and Fr.D in the ML orientation showed a more significant overall effect in explaining mechanical strength than did BMD. In conclusion, trabecular texture parameters correlated significantly with BMD and YM. Trabecular texture parameters from projectional radiographs reflect the anisotropy of trabecular structure. Quantitative radiographic assessment of trabecular structure using fine\u2010detail radiography can potentially improve the estimation of bone strength.<\/jats:p>","DOI":"10.1118\/1.598391","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:01:44Z","timestamp":1027692104000},"page":"2037-2045","source":"Crossref","is-referenced-by-count":38,"title":["Morphometric texture analysis of spinal trabecular bone structure assessed using orthogonal radiographic projections"],"prefix":"10.1002","volume":"25","author":[{"given":"Xiaolong","family":"Ouyang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmila","family":"Majumdar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Link","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Augat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Newitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry K.","family":"Genant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1998,11,13]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650110602"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92555-8"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02555036"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00296208"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(93)90014-6"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(91)90044-J"},{"key":"e_1_2_1_8_1","first-page":"1034","article-title":"The role of calcitonin treatment in postmenopausal osteoporosis","volume":"21","author":"Wallach S.","year":"1992","journal-title":"Orthop. 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