{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T04:55:08Z","timestamp":1696481708910},"reference-count":0,"publisher":"Wiley","issue":"6Part16","license":[{"start":{"date-parts":[[2008,7,9]],"date-time":"2008-07-09T00:00:00Z","timestamp":1215561600000},"content-version":"vor","delay-in-days":38,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:p><jats:bold>Purpose:<\/jats:bold> To investigate the clinical efficacy and effectiveness of 3D\u2010Conformal radiotherapy, Intensity Modulated Radiotherapy (IMRT) using Multileaf Collimators (MLC) and Helical Tomotherapy (HT), by evaluating dosimetric and radiobiological measures of a lung cancer case. <jats:bold>Method and Materials:<\/jats:bold> A typical case of lung cancer has been investigated by developing a 3D\u2010Conformal treatment plan, a linac MLC\u2010based step\u2010and\u2010shoot IMRT plan and a Helical Tomotherapy plan. The treatment plans of the 3D\u2010Conformal and the MLC\u2010based IMRT were developed on the Philips treatment planning station using the Pinnacle 7.6 software release while the dedicated Tomotherapy treatment planning station was used for the HT plan. With the use of the complication\u2010free tumor control probability, <jats:italic>P<\/jats:italic><jats:sub>+<\/jats:sub> and the biologically effective uniform dose, <jats:italic>D\u033f<\/jats:italic> concept as the common prescription point of the plans, the three different treatment plans were compared based on radiobiological measures. <jats:bold>Results:<\/jats:bold> The applied plan evaluation method shows that in this lung cancer case the MLC\u2010based IMRT and the HT treatment plans are almost equivalent over the clinically useful dose prescription range, whereas the 3D\u2010Conformal plan appears to be quite inferior than the other two modalities. More specifically, the 3D\u2010Conformal, MLC\u2010based IMRT and HT treatment plans give a <jats:italic>P<\/jats:italic><jats:sub>+<\/jats:sub> of 55.4%, 72.9% and 66.9%, for a <jats:italic>D\u033f<\/jats:italic> to the target volume of 57.0Gy, 66.9Gy and 64.0Gy, respectively. If a higher than 5% risk for complications could be allowed, the complication\u2010free tumor control could be increased by almost 5% compared to the initial dose prescription. <jats:bold>Conclusion:<\/jats:bold> In comparison to 3D\u2010Conformal radiotherapy, both the MLC based\u2010IMRT and HT can better encompass the often large ITV while minimizing the volume of the OARs receiving high dose. The use of <jats:italic>P \u2010 D\u033f<\/jats:italic> diagrams can compliment the traditional tools of evaluation such as DVHs, in order to compare and effectively evaluate different treatment plans.<\/jats:p>","DOI":"10.1118\/1.2962170","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T21:33:57Z","timestamp":1217280837000},"page":"2821-2822","source":"Crossref","is-referenced-by-count":0,"title":["SU\u2010GG\u2010T\u2010422: Radiobiological Effectiveness of 3D\u2010Conformal Radiotherapy, MLC\u2010Based IMRT and Helical Tomotherapy in Lung Cancer"],"prefix":"10.1002","volume":"35","author":[{"given":"M","family":"Delichas","sequence":"first","affiliation":[]},{"given":"B","family":"Ferreira","sequence":"additional","affiliation":[]},{"given":"C","family":"Shi","sequence":"additional","affiliation":[]},{"given":"A","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[]},{"given":"B","family":"Lind","sequence":"additional","affiliation":[]},{"given":"N","family":"Papanikolaou","sequence":"additional","affiliation":[]},{"given":"P","family":"Mavroidis","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2008,7,9]]},"container-title":["Medical Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1118%2F1.2962170","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1118\/1.2962170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T05:23:13Z","timestamp":1696396993000},"score":1,"resource":{"primary":{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/10.1118\/1.2962170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":0,"journal-issue":{"issue":"6Part16","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1118\/1.2962170"],"URL":"https:\/\/doi.org\/10.1118\/1.2962170","archive":["Portico"],"relation":{},"ISSN":["0094-2405","2473-4209"],"issn-type":[{"value":"0094-2405","type":"print"},{"value":"2473-4209","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}