{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:26:20Z","timestamp":1778617580156,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"7Part1","license":[{"start":{"date-parts":[[2010,6,15]],"date-time":"2010-06-15T00:00:00Z","timestamp":1276560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2010,7]]},"abstract":"Purpose<\/jats:title>Technetium\u201099m has been widely used as an imaging agent but only recently has been considered for therapeutic applications. This study aims to analyze the potential use of Auger electrons for targeted tumor radiotherapy by evaluating the DNA damage and its probability of correct repair and by studying the cellular kinetics, following Auger electron irradiation in comparison to iodine\u2010131 beta minus particles and astatine\u2010211 alpha particle irradiation.<\/jats:p><\/jats:sec>Methods<\/jats:title>Computational models were used to estimate the yield of DNA damage (fast Monte Carlo damage algorithm), the probability of correct repair (Monte Carlo excision repair algorithm), and cell kinetic effects (virtual cell radiobiology algorithm) after irradiation with the selected particles.<\/jats:p><\/jats:sec>Results<\/jats:title>The results obtained with the algorithms used suggested that CKMMX (all M\u2010shell Coster\u2013Kroning\u2014CK\u2014and super\u2010CK transitions) electrons and Auger MXY (all M\u2010shell Auger transitions) have a therapeutic potential comparable to high linear energy transfer alpha particles and higher than beta minus particles. All the other electrons had a therapeutic potential similar to beta minus particles.<\/jats:p><\/jats:sec>Conclusions<\/jats:title> CKMMX electrons and Auger MXY presented a higher probability to induce apoptosis than beta minus particles and a probability similar to alpha particles. Based on the results here, CKMMX electrons and Auger MXY are useful electrons for targeted tumor radiotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1118\/1.3451117","type":"journal-article","created":{"date-parts":[[2010,7,13]],"date-time":"2010-07-13T22:10:32Z","timestamp":1279059032000},"page":"3551-3559","source":"Crossref","is-referenced-by-count":15,"title":["Evaluating Auger electrons for targeted tumor radiotherapy by computational methods"],"prefix":"10.1002","volume":"37","author":[{"given":"Adriana Alexandre S.","family":"Tavares","sequence":"first","affiliation":[]},{"given":"Jo\u00e3o Manuel R. 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