{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:07:04Z","timestamp":1792602424279,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,11,8]],"date-time":"2012-11-08T00:00:00Z","timestamp":1352332800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2012,11]]},"abstract":"\n Many head\u2010and\u2010neck cancer (HNC) patients treated with radiotherapy suffer significant anatomical changes due to tumor shrinkage or weight loss. The purpose of this study was to assess dose changes over target volumes and organs at risk during intensity\u2010modulated radiotherapy for HNC patients. Sixteen HNC IMRT patients, all requiring bilateral neck irradiation, were enrolled in the study. A\n \n was performed and the initial dose distribution was calculated. During the treatment, two subsequent CTs at the 15th\n \n and 25th\n \n fractions were acquired. The initial plan was calculated on the\n \n and\n \n , and dose\u2010volume differences related to the\n \n were assessed. For target volumes, mean values of nearmaximun absorbed dose (\n \n ) increased at the 25th fraction, and doses covering 95% and 98% of volume decreased significantly at the 15th fraction. Contralateral and ipsilateral parotid gland mean doses increased by 6.1% (range: \u20105.4, 23.5%) and 4.7% (range: \u20109.1, 22.3%), respectively, at\n \n . The\n \n in the spinal cord increased by 1.8 Gy at\n \n . Mean absorbed dose increases at\n \n and\n \n were observed in: the lips, 3.8% and 5.3%; the oral cavity, 3.5% and 2.5%; and lower middle neck structure, 1.9% and 1.6%. Anatomical changes during treatment of HNC patients affect dose distribution and induce a loss of dose coverage to target volumes and an overdosage to critical structures. Appropriate organs at risk have to be contoured and monitored in order to know if the initial plan remains suitable during the course of the treatment. Reported dosimetric data can help to identify patients who could benefit from adaptive radiotherapy.\n <\/jats:p>\n PACS numbers: 87.53.Kn, 87.55.Dk<\/jats:p>","DOI":"10.1120\/jacmp.v13i6.3723","type":"journal-article","created":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T17:54:59Z","timestamp":1488218099000},"page":"101-111","source":"Crossref","is-referenced-by-count":48,"title":["Dose variations in tumor volumes and organs at risk during IMRT for head\u2010and\u2010neck cancer"],"prefix":"10.1002","volume":"13","author":[{"given":"Merc\u00e8","family":"Beltran","sequence":"first","affiliation":[{"name":"Servei de F\u00edsica Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma de Barcelona Barcelona 08035 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Ramos","sequence":"additional","affiliation":[{"name":"Servei d'Oncologia Radioter\u00e0pica Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma de Barcelona 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