{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T13:54:46Z","timestamp":1726408486359},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,5,6]],"date-time":"2013-05-06T00:00:00Z","timestamp":1367798400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:p>The role of volumetric\u2010modulated arc therapy (VMAT) in hepatocellular carcinoma (HCC) remains controversial. The purpose of this study was to determine the potential clinical role of VMAT compared with three\u2010dimensional conformal radiotherapy (3D CRT) for liver irradiation. Four\u2010dimensional CT scans of 24 patients with unresectable HCC were included and divided into two groups: (1) adjacent group (<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/acm20081-math-0001.png\" xlink:title=\"urn:x-wiley:15269914:media:acm20081:acm20081-math-0001\" \/>), with planning target volumes overlapping or within 1 cm adjacent to the alimentary tract; (2) nonadjacent group (<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/acm20081-math-0002.png\" xlink:title=\"urn:x-wiley:15269914:media:acm20081:acm20081-math-0002\" \/>), in which the normal liver itself was the dose\u2010limiting structure. Target coverage, organs\u2010at\u2010risk (OARs) doses, delivery parameters, and treatment accuracy were evaluated. Superior target coverage, conformity, and homogeneity were achieved with VMAT compared with 3D CRT. In the adjacent group, VMAT provided superior sparing of serial functioning OARs including the stomach, small intestine, and spinal cord. In the nonadjacent group, VMAT provided inferior sparing of most OARs including the liver, stomach, and small intestine. For the whole group, the effective treatment time was <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/acm20081-math-0003.png\" xlink:title=\"urn:x-wiley:15269914:media:acm20081:acm20081-math-0003\" \/> min for 3D CRT and <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/acm20081-math-0004.png\" xlink:title=\"urn:x-wiley:15269914:media:acm20081:acm20081-math-0004\" \/> min for VMAT. For liver lesions adjacent to the alimentary tract, this study indicates that VMAT should be selected due to the plan quality, delivery efficiency, and superior sparing of stomach and small intestine. However, for liver lesions away from the alimentary tract, VMAT is not superior to 3D CRT for normal tissue protection.<\/jats:p><jats:p>PACS number: 87.55\u2010x.<\/jats:p>","DOI":"10.1120\/jacmp.v14i3.4162","type":"journal-article","created":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T23:05:58Z","timestamp":1488236758000},"page":"81-90","source":"Crossref","is-referenced-by-count":3,"title":["Assessing the role of volumetric\u2010modulated arc therapy in hepatocellular carcinoma"],"prefix":"10.1002","volume":"14","author":[{"given":"Mian","family":"Xi","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oncology in Southern China Sun Yat\u2010sen University  Guangzhou China"},{"name":"Department of Radiation Oncology, Cancer Center Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in Southern China Sun 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