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Ten patients were investigated, with a standard prescription of three dose levels to the target volumes (70, 63, and 56 Gy), using a simultaneous integrated boost in 33 fractions. The automated tool was used to investigate three planning strategies with both IMRT and VMAT: clinically acceptable plan creation, parotid dose sparing, and dose escalation. Clinically acceptable plans were achieved for all patients using both techniques. For parotid\u2010sparing, automated planning reduced the mean dose to a greater extent using VMAT rather than IMRT (17.0 Gy and 19.6 Gy, respectively, <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/acm20213-math-0001.png\" xlink:title=\"urn:x-wiley:15269914:media:acm20213:acm20213-math-0001\"\/>). For dose escalation to the mean of the main clinical target volume, neither VMAT nor IMRT offered a significant benefit over the other. The OAR\u2010limiting prescriptions for VMAT ranged from 84\u201098 Gy, compared to 76\u2010110 Gy for IMRT. Employing a user\u2010independent planning technique, it was possible to objectively compare VMAT and IMRT for nasopharyngeal carcinoma treatment strategies. VMAT offers a parotid\u2010sparing improvement, but no significant benefit was observed for dose escalation to the primary target.<\/jats:p><jats:p>PACS numbers: 87.55.D\u2010, 87.55.kd<\/jats:p>","DOI":"10.1120\/jacmp.v15i1.4530","type":"journal-article","created":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T23:21:15Z","timestamp":1488237675000},"page":"213-225","source":"Crossref","is-referenced-by-count":20,"title":["A bias\u2010free, automated planning tool for technique comparison in radiotherapy \u2010 application to nasopharyngeal carcinoma treatments"],"prefix":"10.1002","volume":"15","author":[{"given":"Christopher","family":"Boylan","sequence":"first","affiliation":[{"name":"The Christie NHS Foundation Trust  Manchester UK"},{"name":"Manchester Academic Health Science Centre (MAHSC) Faculty of Medical and Human Sciences, University of Manchester  Manchester 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