{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:29:47Z","timestamp":1789558187722,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,5,8]],"date-time":"2016-05-08T00:00:00Z","timestamp":1462665600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p>\u201cReg Refine\u201d is a tool available in the MIM Maestro v6.4.5 platform (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.mimsoftware.com\">www.mimsoftware.com<\/jats:ext-link>) that allows the user to actively participate in the deformable image registration process. The purpose of this work was to evaluate the efficacy of this tool and investigate strategies for how to apply it effectively. This was done by performing DIR on two publicly available ground\u2010truth models, the Pixel\u2010based Breathing Thorax Model (POPI) for lung, and the Deformable Image Registration Evaluation Project (DIREP) for head and neck. Image noise matched in both magnitude and texture to clinical CBCT scans was also added to each model to simulate the use case of CBCT\u2013CT alignment. For lung, the results showed Reg Refine effective at improving registration accuracy when controlled by an expert user within the context of large lung deformation. CBCT noise was also shown to have no effect on DIR performance while using the MIM algorithm for this site. For head and neck, the results showed CBCT noise to have a large effect on the accuracy of registration, specifically for low\u2010contrast structures such as the brainstem and parotid glands. In these cases, the Reg Refine tool was able to improve the registration accuracy when controlled by an expert user. Several strategies for how to achieve these results have been outlined to assist other users and provide feedback for developers of similar tools.<\/jats:p><jats:p>PACS number(s): 87.44.Qr, 87.57.nj, 87.57.c<\/jats:p>","DOI":"10.1120\/jacmp.v17i3.6025","type":"journal-article","created":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T00:37:27Z","timestamp":1488242247000},"page":"158-170","source":"Crossref","is-referenced-by-count":32,"title":["Evaluation of the tool \u201cReg Refine\u201d for user\u2010guided deformable image registration"],"prefix":"10.1002","volume":"17","author":[{"given":"Perry B.","family":"Johnson","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Miller School of Medicine, University of Miami  Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle R.","family":"Padgett","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Miller School of Medicine, University of Miami  Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan L.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Willis\u2010Knighton Cancer Center  Shreveport LA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesrin","family":"Dogan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Miller School of Medicine, University of Miami  Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.4889259"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1120\/jacmp.v11i1.3081"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.4901523"},{"key":"e_1_2_7_5_1","unstructured":"VandemeulebrouckeJ SarrutD ClarysseP.The POPI\u2010model a point\u2010validated pixel\u2010based breathing thorax model.Presented at the XVth International conference on the use of computers in radiation therapy (ICCR) 2007;Toronto Canada."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/54\/7\/001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.4823467"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/58\/21\/7661"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.2837292"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1120\/jacmp.v14i6.4363"},{"key":"e_1_2_7_11_1","volume-title":"Deformable image registration in MIM Maestro evaluation and description","author":"Piper J","year":"2013"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.4815320"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.4800795"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.599009"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.4736234"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.08.031"}],"container-title":["Journal of Applied Clinical Medical Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1120%2Fjacmp.v17i3.6025","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1120%2Fjacmp.v17i3.6025","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/pdf\/10.1120\/jacmp.v17i3.6025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T18:44:49Z","timestamp":1696617889000},"score":1,"resource":{"primary":{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/10.1120\/jacmp.v17i3.6025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1120\/jacmp.v17i3.6025"],"URL":"https:\/\/doi.org\/10.1120\/jacmp.v17i3.6025","archive":["Portico"],"relation":{},"ISSN":["1526-9914","1526-9914"],"issn-type":[{"value":"1526-9914","type":"print"},{"value":"1526-9914","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5]]}}}