{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T13:54:25Z","timestamp":1760709265365},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,5,8]],"date-time":"2016-05-08T00:00:00Z","timestamp":1462665600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2016,5]]},"abstract":"The presence of two intact lungs makes it challenging to reach a tumoricidal dose with hemithoracic pleural intensity\u2010modulated radiation therapy (IMRT) in patients with malignant pleural mesothelioma (MPM) who underwent pleurectomy\/decortications or have unresectable disease. We developed an anatomy\u2010based model to predict attainable prescription dose before starting optimization. Fifty\u2010six clinically delivered IMRT plans were analyzed regarding correlation of prescription dose and individual and total lung volumes, planning target volume (PTV), ipsilateral normal lung volume and ratios: contralateral\/ipsilateral lung (CIVR); contralateral lung\/PTV (CPVR); ipsilateral lung \/PTV (IPVR); ipsilateral normal lung \/total lung (INTLVR); ipsilateral normal lung\/PTV (INLPVR). Spearman's rank correlation and Fisher's exact test were used. Correlation between mean ipsilateral lung dose (MILD) and these volume ratios and between prescription dose and single lung mean doses were studied. The prediction models were validated in 23 subsequent MPM patients. CIVR showed the strongest correlation with dose () and accurately predicted prescription dose in the validation cases. INLPVR and MILD as well as MILD and prescription dose were significantly correlated ( and , respectively) in the training and validation cases. Parameters obtainable directly from planning scan anatomy predict achievable prescription doses for hemithoracic IMRT treatment of MPM patients with two intact lungs.<\/jats:p>PACS number(s): 87.55.de, 87.55.dk<\/jats:p>","DOI":"10.1120\/jacmp.v17i3.6199","type":"journal-article","created":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T00:37:27Z","timestamp":1488242247000},"page":"371-379","source":"Crossref","is-referenced-by-count":6,"title":["Geometric dose prediction model for hemithoracic intensity\u2010modulated radiation therapy in mesothelioma patients with two intact lungs"],"prefix":"10.1002","volume":"17","author":[{"given":"LiCheng","family":"Kuo","sequence":"first","affiliation":[{"name":"Department of Medical Physics Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen D.","family":"Yorke","sequence":"additional","affiliation":[{"name":"Department of Medical Physics Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishruta A.","family":"Dumane","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Mount Sinai Medical Center New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Foster","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhigang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James G.","family":"Mechalakos","sequence":"additional","affiliation":[{"name":"Department of Medical Physics Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abraham J.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth E.","family":"Rosenzweig","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Mount Sinai Medical Center New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Rimner","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)04151-2"},{"issue":"4","key":"e_1_2_7_3_1","first-page":"457","article-title":"Novel radiation therapy approaches in malignant pleural mesothelioma","volume":"1","author":"Rimner A","year":"2012","journal-title":"Ann Cardiothorac Surg."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.03.041"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.03.012"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.03.011"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.09.027"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(98)90033-5"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.597345"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(91)90172-Z"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.07.1754"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00183-2"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21007"},{"key":"e_1_2_7_14_1","unstructured":"NCI Community Oncology Research Program Protocol Summary.RTOG 1106: Randomized phase II trial of individualized adaptive radiotherapy using during\u2010treatment FDG\u2010PET\/CT and modern technology in locally advanced non\u2010small cell lung cancer (NSCLC). Available at:http:\/\/www.kccop.org\/cancer\u2010trials\/lung\/index.cgi\/summary?tID=64"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.07.029"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2013.10.013"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.05.028"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.11.030"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.3253464"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.05.026"}],"container-title":["Journal of Applied Clinical Medical Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1120%2Fjacmp.v17i3.6199","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1120%2Fjacmp.v17i3.6199","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/pdf\/10.1120\/jacmp.v17i3.6199","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T18:43:26Z","timestamp":1696617806000},"score":1,"resource":{"primary":{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/10.1120\/jacmp.v17i3.6199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1120\/jacmp.v17i3.6199"],"URL":"https:\/\/doi.org\/10.1120\/jacmp.v17i3.6199","archive":["Portico"],"relation":{},"ISSN":["1526-9914","1526-9914"],"issn-type":[{"value":"1526-9914","type":"print"},{"value":"1526-9914","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5]]}}}