{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T21:33:56Z","timestamp":1757453636014},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,11,8]],"date-time":"2016-11-08T00:00:00Z","timestamp":1478563200000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2016,11]]},"abstract":"To evaluate the feasibility of radiation dose reduction using model\u2010based iterative reconstruction (MBIR) for evaluating the ureters and vasculature in a phantom, a tissue\u2010equivalent CT dose phantom was scanned using a 64\u2010channel CT scanner. Tubes of varying diameters filled with different dilutions of a contrast agent, simulating ureters or vessels, were inserted into the center of the phantom. Each combination was scanned using an existing renal protocol at 140 kVp or 120 kVp, yielding a display volumetric CT dose index () of 24 mGy. The scans were repeated using reduced scan techniques to achieve lower radiation doses down to 0.8 mGy. The images were reconstructed using filtered back\u2010projection (FBP) and model\u2010based iterative reconstruction (MBIR). The noise and contrast\u2010to\u2010noise ratio (CNR) was measured for each contrast object. Comparisons between the two reconstruction methods at different dose levels were evaluated using a factorial design. At each the measured image noise was lower using MBIR compared to FBP (). At low doses, the percent change in measured image noise between FBP and MBIR was larger. For the 12 mm object simulating a ureter or large vessel with an HU of 600, the measured CNR using MBIR at a of 1.7 mGy was greater than the CNR of FBP at a of 24 mGy (). For the 5 mm object simulating a medium\u2010sized vessel with a HU of 250, the measured CNR using MBIR at a of 1.7 mGy was equivalent to that of FBP at a of 24 mGy. For the 2 mm, 100 HU object simulating a small vessel, the measured CNR using MBIR at a of 1.7 mGy was equivalent to that of FBP at a of 24 mGy. Low\u2010dose (3.6 mGy) CT imaging of vasculature and ureter phantoms using MBIR results in similar noise and CNR compared to FBP at approximately one\u2010sixth the dose. This suggests that, using MBIR, a one milliSievert exam of the ureters and vasculature may be clinically possible whilst still maintaining adequate image quality<\/jats:p>PACS number(s): 87.57.\u2010s, 87.57.Q\u2010, 87.57.C\u2010, 87.57.nf, 87.57.cj, 87.57.cm<\/jats:p>","DOI":"10.1120\/jacmp.v17i6.6184","type":"journal-article","created":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T00:58:12Z","timestamp":1488243492000},"page":"334-342","source":"Crossref","is-referenced-by-count":3,"title":["Dose reduction in CT urography and vasculature phantom studies using model\u2010based iterative reconstruction"],"prefix":"10.1002","volume":"17","author":[{"given":"Leland","family":"Page","sequence":"first","affiliation":[{"name":"Department of Imaging Physics The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Biostatistics The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikas","family":"Kundra","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology The University of Texas MD Anderson Cancer Center Houston TX USA"},{"name":"Department of Cancer Systems Imaging The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X. 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