{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:37:29Z","timestamp":1767166649060,"version":"build-2238731810"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,11,24]],"date-time":"2004-11-24T00:00:00Z","timestamp":1101254400000},"content-version":"vor","delay-in-days":84,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2004,9]]},"abstract":"\n For the case of pharyngeal carcinomas, the clinical value as well as the stability of several evaluation methods of MR tomographic perfusion measurement are compared. Eighteen patients suffering from histologically proven squamous cell carcinomas were investigated by MR tomography (1.5 T, 0.2 mmol\/kg Gd\u2010DTPA) prior to and during radiation therapy. Perfusion measurements were performed using a double\u2010echo FLASH sequence. Parameters describing regional blood flow, blood volume, mean transit time, and interstitial concentration of contrast medium (CM) were calculated, applying seven different combinations of correction approaches (separating the shortening of\n \n and\n \n , arterial input function (AIF), and tumor shunts). Their correlations to MR independent tumor physiological parameters were analyzed (metabolic activity measurements using\n 18<\/jats:sup>\n F\u2010FDG\u2010PET, polarographical\n \n measurement, tumor volume). Significant improvements of the correlation between perfusion\u2010dependent and other tumor physiological parameters could be achieved by decoupling the shortening of\n \n and\n \n and by applying of the tumor shunt model. Deconvolution from the AIF deteriorated the correlation. Therefore, the elimination of the\n \n shortening due to interstitial CM proves to be essential for MR perfusion measurements on contrast medium uptaking lesions. Depending on the measurement conditions (temporal resolution, signal\u2010to\u2010noise ratio), the consideration of the AIF can even make the results significantly worse by introducing additional measuring errors.\n <\/jats:p>\n PACS numbers: 87.61.\u2010c<\/jats:p>","DOI":"10.1120\/jacmp.v5i4.2009","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T17:09:37Z","timestamp":1172164177000},"page":"96-111","source":"Crossref","is-referenced-by-count":1,"title":["MR perfusion measurements on pharyngeal tumors: Comparison of quantification strategies"],"prefix":"10.1002","volume":"5","author":[{"given":"Volker","family":"Hietschold","sequence":"first","affiliation":[{"name":"University of Technology Dresden Department of Diagnostic Radiology Fetscherstr. 74, D\u201301307 Dresden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Kittner","sequence":"additional","affiliation":[{"name":"University of Technology Dresden Department of Diagnostic Radiology Fetscherstr. 74, D\u201301307 Dresden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Schreyer","sequence":"additional","affiliation":[{"name":"University of Technology Dresden Department of Diagnostic Radiology Fetscherstr. 74, D\u201301307 Dresden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Appold","sequence":"additional","affiliation":[{"name":"University of Technology Dresden Clinic of Radiation Therapy and Radiation Oncology Fetscherstr. 74, D\u201301307 Dresden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"Beuthien\u2010Baumann","sequence":"additional","affiliation":[{"name":"University of Technology Dresden Clinic of Nuclear Medicine\/PET Center Rossendorf Fetscherstr. 74, D\u201301307 Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Laniado","sequence":"additional","affiliation":[{"name":"University of Technology Dresden Department of Diagnostic Radiology Fetscherstr. 74, D\u201301307 Dresden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,11,24]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"Radiobiology for the radiologist","author":"Hall EJ","year":"1994"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-4296(98)80043-X"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(94)90434-0"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-66-783-181"},{"key":"e_1_2_5_6_1","unstructured":"KittnerT AppoldS Beuthien\u2010BaumannB HietscholdV LaniadoM BaumannM.Tumorphysiologische Untersuchungen bei inoperablen pharyngealen Malignomen mittels MRT PET und\u2010Sondenmessung.Exp Strahlentherapie und Klinische Strahlenbiologie;2002.79\u201382. 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