{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T10:19:50Z","timestamp":1696673990102},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,4,11]],"date-time":"2007-04-11T00:00:00Z","timestamp":1176249600000},"content-version":"vor","delay-in-days":41,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2007,3]]},"abstract":"The first aim of the present study was to investigate the feasibility of using fewer beam angles to improve delivery efficiency for the treatment of oropharyngeal cancer (OPC) with inverse\u2010planned intensity\u2010modulated radiation therapy (IP\u2010IMRT). A secondary aim was to evaluate whether the simplified IP\u2010IMRT plans could reduce the indirect radiation dose. The treatment plans for 5 consecutive OPC patients previously treated with a forward\u2010planned IMRT (FP\u2010IMRT) technique were selected as benchmarks for this study. The initial treatment goal for these patients was to deliver 70 Gy to of the planning gross tumor volume (PTV\u201070) and 59.4 Gy to of the planning clinical tumor volume (PTV\u201059.4) simultaneously. Each case was re\u2010planned using IP\u2010IMRT with multiple beam\u2010angle arrangements, including four complex IP\u2010IMRT plans using 7 or more beam angles, and one simple IMRT plan using 5 beam angles. The complex IP\u2010IMRT plans and simple IP\u2010IMRT plans were compared to each other and to the FP\u2010IMRT plans by analyzing the dose coverage of the target volumes, the plan homogeneity, the dose\u2013volume histograms of critical structures, and the treatment delivery parameters including delivery time and the total number of monitor units (MUs). When comparing the plans, we found no significant difference between the complex IP\u2010IMRT, simple IP\u2010IMRT, and FP\u2010IMRT plans for tumor target coverage (PTV\u201070: ; PTV\u201059.4: ). The plan homogeneity, measured by the mean percentage isodose, did not significantly differ between the IP\u2010IMRT and FP\u2010IMRT plans , although we observed a trend toward greater inhomogeneity of dose in the simple IP\u2010IMRT plans. All IP\u2010IMRT plans either met or exceeded the quality of the FP\u2010IMRT plans in terms of dose to adjacent critical structures, including the parotids, spinal cord, and brainstem. As compared with the complex IP\u2010IMRT plans, the simple IP\u2010IMRT plans significantly reduced the mean treatment time (maximum probability for four pairwise comparisons: ). In conclusion, our study demonstrates that, as compared with complex IP\u2010IMRT, simple IP\u2010IMRT can significantly improve treatment delivery efficiency while maintaining similar target coverage and sparing of critical structures. However, the improved efficiency does not significantly reduce the total number of MUs nor the indirect radiation dose.<\/jats:p>PACS number: 87.53.tf<\/jats:p>","DOI":"10.1120\/jacmp.v8i2.2412","type":"journal-article","created":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T21:43:25Z","timestamp":1488231805000},"page":"26-36","source":"Crossref","is-referenced-by-count":6,"title":["Simplifying intensity\u2010modulated radiotherapy plans with fewer beam angles for the treatment of oropharyngeal carcinoma"],"prefix":"10.1002","volume":"8","author":[{"given":"Robert","family":"Takamiya","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology University of California\u2013San Francisco San Francisco California U.S.A."},{"name":"Comprehensive Cancer Center University of California\u2013San Francisco San Francisco California 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