{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T15:00:08Z","timestamp":1775919608429,"version":"3.50.1"},"reference-count":70,"publisher":"Acoustical Society of America (ASA)","issue":"6","content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,12,1]]},"abstract":"<jats:p>The effect of age on susceptibility to noise-induced hearing loss (NIHL), the effect of gender on the interaction of age-related hearing loss (ARHL) and NIHL, and the relative contributions of ARHL and NIHL to total hearing loss are poorly understood. The issues are difficult to resolve empirically in human subjects because of lack of control over extrinsic variables and for ethical reasons. Accordingly, these issues were examined in a well-studied animal model of both ARHL and NIHL, the Mongolian gerbil. Animals were exposed to an intense tone (3.5 kHz, 113 dB SPL, 1 h) either as young adults (6\u20138 months) or near the end of the average lifespan of the species (34\u201338 months). Hearing thresholds were determined with the auditory brainstem response (ABR). ARHL was approximately 5\u201310 dB, with slightly more observed in males at 16 kHz (p&amp;lt;0.05). NIHL of approximately 15\u201320 dB was similar for the young and old groups, suggesting no differences in susceptibility as a function of age. There were no gender differences in NIHL. The relative contributions of ARHL and NIHL to total hearing loss in aged, noise-exposed gerbils were predicted by an addition of ARHL and NIHL in dB, similar to an international standard on hearing loss allocation, ISO-1999 [Determination of Occupational Noise Exposure and Estimation of Noise-Induced Hearing Impairment (1990)]. Previous evaluations of ISO-1999 using the gerbil animal model concluded that addition of ARHL and NIHL in dB overpredicts total hearing loss. However, in these studies, ARHL was large and nearly equal to NIHL. In the current study, where ARHL was much less than NIHL, addition of the two factors in dB, as recommended by ISO-1999, results in fairly accurate predictions of total hearing loss.<\/jats:p>","DOI":"10.1121\/1.1513364","type":"journal-article","created":{"date-parts":[[2002,12,12]],"date-time":"2002-12-12T16:44:32Z","timestamp":1039711472000},"page":"2948-2955","update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":22,"title":["Susceptibility to acoustic trauma in young and aged gerbils"],"prefix":"10.1121","volume":"112","author":[{"given":"Flint A.","family":"Boettcher","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head & Neck Surgery, Medical University of South Carolina, 39 Sabin Street, Room 608, P.O. Box 250150, Charleston, South Carolina\u200929425"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"231","published-online":{"date-parts":[[2002,12,5]]},"reference":[{"key":"2023071404034765400_bau73"},{"key":"2023071404034765400_ber78","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1121\/1.381984","article-title":"Presumed noise-induced permanent threshold shift resulting from exposure to an A-weighted Leq of 89 dB","volume":"64","year":"1978","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071404034765400_bie90","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1121\/1.399677","article-title":"An alternative mathematical description of the relationship between noise exposure and hearing loss","volume":"88","year":"1990","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071404034765400_boe93","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1121\/1.407226","article-title":"Auditory brain-stem response correlates of resistance to noise-induced hearing loss in the Mongolian gerbil","volume":"94","year":"1993","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071404034765400_boe95","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1121\/1.413811","article-title":"Distortion-product otoacoustic emissions in Mongolian gerbils with resistance to noise-induced hearing loss","volume":"98","year":"1995","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071404034765400_boe93a","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0378-5955(93)90029-Z","article-title":"Age-related changes in auditory evoked potentials of gerbils. I. Response amplitudes","volume":"71","year":"1993","journal-title":"Hear. Res."},{"key":"2023071404034765400_boe93b","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/0378-5955(93)90030-5","article-title":"Age-related changes in auditory evoked-potentials of gerbils. II. Response latencies","volume":"71","year":"1993","journal-title":"Hear. Res."},{"key":"2023071404034765400_boh90","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0378-5955(90)90200-9","article-title":"Morphological correlates of aging in the chinchilla cochlea","volume":"48","year":"1990","journal-title":"Hear. Res."},{"key":"2023071404034765400_bur70"},{"key":"2023071404034765400_cor76"},{"key":"2023071404034765400_dob93"},{"key":"2023071404034765400_dol96","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1044\/jshr.3902.251","article-title":"Noise exposure associated with hearing aid use in industry","volume":"39","year":"1996","journal-title":"J. Speech Hear. Res."},{"key":"2023071404034765400_dol85","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0378-5955(85)90038-3","article-title":"Brainstem, whole-nerve AP and single-fiber suppression in the gerbil: normative data","volume":"18","year":"1985","journal-title":"Hear. Res."},{"key":"2023071404034765400_erw93","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0378-5955(93)90207-H","article-title":"Genetics of age-related hearing loss in mice: I. Inbred and F1 hybrid strains","volume":"65","year":"1993","journal-title":"Hear. Res."},{"key":"2023071404034765400_erw96","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0378-5955(95)00226-X","article-title":"Genetics of age-related hearing loss in mice. III. Susceptibility of inbred and F1 hybrid strains to noise-induced hearing loss","volume":"93","year":"1996","journal-title":"Hear. Res."},{"key":"2023071404034765400_fel95","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0378-5955(95)00158-1","article-title":"Quantitative evaluation of myelinated nerve fibers and hair cells in cochleae of humans with age-related high-tone hearing loss","volume":"91","year":"1995","journal-title":"Hear. Res."},{"key":"2023071404034765400_fel97","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0378-5955(96)00209-2","article-title":"Quantitative evaluation of cochlear neurons and computer-aided three dimensional reconstruction of spiral ganglion cells in humans with a peripheral loss of nerve fibers","volume":"105","year":"1997","journal-title":"Hear. Res."},{"key":"2023071404034765400_gal64","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1080\/00028896409342582","article-title":"Permanent threshold shift changes produced by noise exposure and aging","volume":"25","year":"1964","journal-title":"Am. Ind. Hyg. Assoc. J."},{"key":"2023071404034765400_gat90","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/00003446-199008000-00001","article-title":"Hearing in the elderly: The Framingham cohort, 1983\u20131985","volume":"11","year":"1990","journal-title":"Ear Hear."},{"key":"2023071404034765400_glo65"},{"key":"2023071404034765400_gra95","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/0378-5955(94)00161-I","article-title":"Alterations in microvasculature are associated with atrophy of the stria vascularis in quiet-aged gerbils","volume":"82","year":"1995","journal-title":"Hear. Res."},{"key":"2023071404034765400_ham86","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1121\/1.394052","article-title":"Impulse noise: Critical review","volume":"80","year":"1986","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071404034765400_hum91","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1121\/1.401286","article-title":"Modeling the interaction between noise exposure and other variables","volume":"90","year":"1991","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071404034765400_iso90"},{"key":"2023071404034765400_joh78"},{"key":"2023071404034765400_kei89","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0378-5955(89)90134-2","article-title":"Spiral ganglion cell density in young and old gerbils","volume":"38","year":"1989","journal-title":"Hear. Res."},{"key":"2023071404034765400_li92","doi-asserted-by":"crossref","first-page":"956","DOI":"10.3109\/00016489209137496","article-title":"Influence of genotype and age on acute acoustic trauma and recovery in CBA\/Ca and C57BL\/6J mice","volume":"112","year":"1992","journal-title":"Acta Oto-Laryngol."},{"key":"2023071404034765400_lut96","first-page":"1","article-title":"Estimation of noise-induced hearing impairment for compound noise exposures based on ISO 1999","volume":"5","year":"1996","journal-title":"J. Audiol. Med."},{"key":"2023071404034765400_mac71","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3109\/00206097109072569","article-title":"Noise-induced hearing loss and presbyacusis","volume":"10","year":"1971","journal-title":"Audiology"},{"key":"2023071404034765400_mac91a","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1121\/1.402055","article-title":"Presbycusis and noise-induced permanent threshold shift","volume":"90","year":"1991","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071404034765400_mac91b","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1044\/jshr.3402.403","article-title":"Permanent threshold shift associated with overamplification by hearing aids","volume":"34","year":"1991","journal-title":"J. Speech Hear. Res."},{"key":"2023071404034765400_mcf99","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/00003446-199904000-00007","article-title":"Sex differences in auditory sensitivity of chinchilla before and after exposure to impulse noise","volume":"20","year":"1999","journal-title":"Ear Hear."},{"key":"2023071404034765400_mcf00","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1121\/1.428497","article-title":"Conditioning-induced protection from impulse noise in female and male chinchillas","volume":"107","year":"2000","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071404034765400_mcf97","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0378-5955(97)00099-3","article-title":"Age-related decline of auditory function in the chinchilla (Chinchilla laniger)","volume":"111","year":"1997","journal-title":"Hear. Res."},{"key":"2023071404034765400_mil98","first-page":"53","article-title":"Interactive effects of aging with noise induced hearing loss","volume":"48","year":"1998","journal-title":"Scand. Audiol. Suppl."},{"key":"2023071404034765400_mil92"},{"key":"2023071404034765400_mil90","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0378-5955(90)90002-7","article-title":"Age related changes in auditory potentials of Mongolian gerbils","volume":"46","year":"1990","journal-title":"Hear. Res."},{"key":"2023071404034765400_mil97","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1121\/1.418152","article-title":"Interaction of noise-induced permanent threshold shift and age-related threshold shift","volume":"101","year":"1997","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071404034765400_mill98","first-page":"117","article-title":"Interaction of noise-induced hearing loss and presbyacusis","volume":"27","year":"1998","journal-title":"Scand. Audiol."},{"key":"2023071404034765400_mil01","first-page":"82","article-title":"Deriving estimates of auditory sensitivity in quiet-aged domestic gerbils","volume":"24","year":"2001","journal-title":"Assoc. Res. Otolaryngol."},{"key":"2023071404034765400_mil77","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3109\/03005367709078825","article-title":"A longitudinal study of hearing loss in older people","volume":"11","year":"1977","journal-title":"Br. J. Audiol."},{"key":"2023071404034765400_mil75","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3109\/03005367509079109","article-title":"Pure tone audiometry in older people","volume":"9","year":"1975","journal-title":"Br. J. Audiol."},{"key":"2023071404034765400_mol81","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0196-0709(81)80005-1","article-title":"Hearing in 70 and 75 year old people: Results from a cross section and longitudinal population study","volume":"2","year":"1981","journal-title":"Am. J. Otolaryngol."},{"key":"2023071404034765400_mos85","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/00003446-198507000-00003","article-title":"Hearing loss in the elderly: An epidemiologic study of the Framingham Heart Study Cohort","volume":"6","year":"1985","journal-title":"Ear Hear."},{"key":"2023071404034765400_mul89","first-page":"505","article-title":"Ist die These von der h\u00f6heren L\u00e4rmresistenz berufst\u00e4tiger Frauen aufrechthaltbar?","volume":"35","year":"1989","journal-title":"Z. Gesamte Hyg."},{"key":"2023071404034765400_nov75","first-page":"151","article-title":"Development of occupational deafness after entering a noisy employment in older age","volume":"24","year":"1975","journal-title":"Cesk Otolaryngol."},{"key":"2023071404034765400_osh71"},{"key":"2023071404034765400_osh81"},{"key":"2023071404034765400_ohl00","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0378-5955(00)00191-X","article-title":"Vulnerability to noise-induced hearing loss in \u2018middle-aged\u2019 and young adult mice: a dose-response approach in CBA, C57BL, and BALB inbred strains","volume":"149","year":"2000","journal-title":"Hear. Res."},{"key":"2023071404034765400_pas77"},{"key":"2023071404034765400_pea95","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1121\/1.412231","article-title":"Gender differences in a longitudinal study of age-associated hearing loss","volume":"97","year":"1995","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071404034765400_ped89","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3109\/00206098909081624","article-title":"Changes in pure-tone thresholds in individuals aged 70\u201381: Results from a longitudinal study","volume":"28","year":"1989","journal-title":"Audiology"},{"key":"2023071404034765400_rob88","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3109\/03005368809077793","article-title":"Threshold of hearing as a function of age and sex for the typical unscreened population","volume":"22","year":"1988","journal-title":"Br. J. Audiol."},{"key":"2023071404034765400_rob91","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3109\/03005369109079839","article-title":"Relation between hearing threshold level and its component parts","volume":"25","year":"1991","journal-title":"Br. J. Audiol."},{"key":"2023071404034765400_rob79","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1080\/00206097909072634","article-title":"Age effect in hearing: A comparative analysis of published threshold data","volume":"18","year":"1979","journal-title":"Audiology"},{"key":"2023071404034765400_sch90","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0378-5955(90)90122-6","article-title":"Tuning and suppression in auditory nerve fibers of aged gerbils raised in quiet or noise","volume":"45","year":"1990","journal-title":"Hear. Res."},{"key":"2023071404034765400_sch92","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0378-5955(92)90034-K","article-title":"Na-K-ATPase and endocochlear potentials decline in quiet-aged gerbils","volume":"61","year":"1992","journal-title":"Hear. Res."},{"key":"2023071404034765400_sch93","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/00034894931020S101","article-title":"Cochlear pathology in presbyacusis","volume":"102","year":"1993","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"2023071404034765400_sho91","first-page":"39","article-title":"The effect of noise exposure on the aging ear","volume":"134","year":"1991","journal-title":"Hear. Res."},{"key":"2023071404034765400_spo97","doi-asserted-by":"crossref","first-page":"3546","DOI":"10.1121\/1.418315","article-title":"Quantitative measures of hair cell loss in CBA and C57BL\/6 mice throughout their life spans","volume":"101","year":"1997","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071404034765400_sun94","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1288\/00005537-199410000-00012","article-title":"Is the older ear more susceptible to noise?","volume":"104","year":"1994","journal-title":"Laryngoscope"},{"key":"2023071404034765400_tar91","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0378-5955(91)90142-V","article-title":"Age-related changes in cochleas of Mongolian gerbils","volume":"54","year":"1991","journal-title":"Hear. Res."},{"key":"2023071404034765400_tho97","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0378-5955(97)00080-4","article-title":"Age-related thickening of basement membrane in stria vascularis capillaries","volume":"111","year":"1997","journal-title":"Hear. Res."},{"key":"2023071404034765400_war66","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1121\/1.1910099","article-title":"Temporary threshold shift in males and females","volume":"40","year":"1966","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071404034765400_war95","first-page":"561","article-title":"Endogenous factors related to susceptibility to damage from noise","volume":"10","year":"1995","journal-title":"Occup. Med."},{"key":"2023071404034765400_wel78","first-page":"1037","article-title":"Einfluss von expositionszeit und alter auf den iarmbedingten horverlust [Influence of exposure time and age on noise-induced hearing loss: Observations of 25,544 industrial workers (translation by authors, cited in Dobie, 1993)]","volume":"57","year":"1978","journal-title":"Laryngol. Rhinol. Otol. (Stuttg)"},{"key":"2023071404034765400_wel80","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1055\/s-2007-1008914","article-title":"Ist das L\u00e4rschwerh\u00f6rigkeitsrisiko f\u00fcr M\u00e4nner gr\u00f6sser als f\u00fcr Frauen?","volume":"59","year":"1980","journal-title":"Laryngol. Rhinol. Otol. (Stuttg)"},{"key":"2023071404034765400_whi98","first-page":"566","article-title":"Effectiveness of intermittent and continuous acoustic stimulation in preventing noise-induced hearing I and hair cell loss","volume":"103","year":"1998","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071404034765400_wil91","first-page":"16","article-title":"Age-related cochlear histopathology in C57BL\/6J and CBA\/J mice","volume":"14","year":"1991","journal-title":"Assoc. Res. Otolaryngol. Abstracts."},{"key":"2023071404034765400_wil98","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0378-5955(97)00189-5","article-title":"The BALB\/c mouse as an animal model for progressive sensorineural hearing loss","volume":"115","year":"1998","journal-title":"Hear. Res."}],"container-title":["The Journal of the Acoustical Society of America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.aip.org\/asa\/jasa\/article-pdf\/112\/6\/2948\/8090952\/2948_1_online.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.aip.org\/asa\/jasa\/article-pdf\/112\/6\/2948\/8090952\/2948_1_online.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T07:41:47Z","timestamp":1704699707000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.aip.org\/jasa\/article\/112\/6\/2948\/544311\/Susceptibility-to-acoustic-trauma-in-young-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,12,1]]},"references-count":70,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,12,1]]}},"URL":"https:\/\/doi.org\/10.1121\/1.1513364","relation":{},"ISSN":["0001-4966","1520-8524"],"issn-type":[{"value":"0001-4966","type":"print"},{"value":"1520-8524","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2002,12]]},"published":{"date-parts":[[2002,12,1]]}}}