{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T21:08:11Z","timestamp":1789679291399,"version":"4.0.1"},"reference-count":23,"publisher":"Acoustical Society of America (ASA)","issue":"5","content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,5,1]]},"abstract":"<jats:p>Correlations between acoustic properties and bone density were investigated in the 12 defatted bovine cancellous bone specimens in vitro. Speed of sound (SOS) and broadband ultrasonic attenuation (BUA) were measured in three different frequency bandwidths from 0.5 to 2 MHz using three matched pairs of transducers with the center frequencies of 1, 2.25, and 3.5 MHz. The relative orientation between ultrasonic beam and bone specimen was the mediolateral (ML) direction of the bovine tibia. SOS shows significant linear positive correlation with apparent density for all three pairs of transducers. However, BUA shows relatively weak correlation with apparent density. SOS and BUA are only weakly correlated with each other. The linear combination of SOS and BUA in a multiple regression model leads to a significant improvement in predicting apparent density. The correlations among SOS, BUA, and bone density can be effectively and clearly represented in the three-dimensional space by the multiple regression model. These results suggest that the frequency range up to 1.5 MHz and the multiple regression model in the three-dimensional space can be useful in the osteoporosis diagnosis.<\/jats:p>","DOI":"10.1121\/1.1567733","type":"journal-article","created":{"date-parts":[[2003,5,9]],"date-time":"2003-05-09T14:09:08Z","timestamp":1052489348000},"page":"2933-2938","update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["Correlations between acoustic properties and bone density in bovine cancellous bone from 0.5 to 2 MHz"],"prefix":"10.1121","volume":"113","author":[{"given":"Kang Il","family":"Lee","sequence":"first","affiliation":[{"name":"Acoustics Research Laboratory and BK21 Physics Research Division, Department of Physics, SungKyunKwan University, Suwon\u2009440-746, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heui-Seol","family":"Roh","sequence":"additional","affiliation":[{"name":"Acoustics Research Laboratory and BK21 Physics Research Division, Department of Physics, SungKyunKwan University, Suwon\u2009440-746, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suk Wang","family":"Yoon","sequence":"additional","affiliation":[{"name":"Acoustics Research Laboratory and BK21 Physics Research Division, Department of Physics, SungKyunKwan University, Suwon\u2009440-746, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"231","published-online":{"date-parts":[[2003,5,5]]},"reference":[{"key":"2023071404495891600_r1","first-page":"73","article-title":"Analysis of the error in measurement of ultrasound speed of sound in tissues due to waveform deformation by frequency-dependent attenuation","volume":"19","year":"1981","journal-title":"Ultrasonics"},{"key":"2023071404495891600_r2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1243\/EMED_JOUR_1984_013_022_02","article-title":"The measurement of broadband ultrasonic attenuation in cancellous bone","volume":"13","year":"1984","journal-title":"Eng. 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