{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:53:34Z","timestamp":1791154414930,"version":"4.1.0"},"reference-count":38,"publisher":"Acoustical Society of America (ASA)","issue":"1","content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,7,1]]},"abstract":"<jats:p>The persistence of afferent activity at stimulus offset was examined in mice as a function of age (experiment 1) and noise level (experiment 2), using a procedure devised by von Bekesy to study the physiological decay of afferent activity. Noise offset was presented from 1 to 10 ms (the temporal gap) prior to an acoustic startle stimulus, with an abrupt edge or a linear ramp having the duration of the gap. Noise offset inhibited the startle reflex, this effect declining with age. For young (2\u20133 months old) and \u201cyoung-old\u201d mice (18\u201319 months old), the abrupt offset was always more inhibitory than the ramp, even for the one millisecond gap. In \u201cold-old\u201d mice (24\u201326 months old) abrupt and ramped offsets were not different until the gap exceeded 4 ms. The behavioral difference between abrupt and ramped decay times did not depend on noise level in young mice (4\u20135 months old), though overall inhibition increased with level. These data indicate that temporal acuity as measured by this gap detection method is limited in very old mice by their reduced ability to follow the abrupt change in noise level at the beginning of the gap.<\/jats:p>","DOI":"10.1121\/1.1577553","type":"journal-article","created":{"date-parts":[[2003,7,7]],"date-time":"2003-07-07T15:04:01Z","timestamp":1057590241000},"page":"522-528","update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":19,"title":["A diminished rate of \u201cphysiological decay\u201d at noise offset contributes to age-related changes in temporal acuity in the CBA mouse model of presbycusis"],"prefix":"10.1121","volume":"114","author":[{"given":"James R.","family":"Ison","sequence":"first","affiliation":[{"name":"Department of Brain and Cognitive Sciences, Meliora Hall, University of Rochester, Rochester, New York 14627"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Brain and Cognitive Sciences, Meliora Hall, University of Rochester, Rochester, New York 14627"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"231","published-online":{"date-parts":[[2003,7,3]]},"reference":[{"key":"2023071402282439300_all02","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1121\/1.1518697","article-title":"Humans detect gaps in broadband noise according to effective quiet time without additional cues from abrupt envelope changes","volume":"112","year":"2002","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071402282439300_bal01","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1152\/jn.2001.86.5.2299","article-title":"Potassium currents in octopus cells of the mammalian cochlear nucleus","volume":"86","year":"2001","journal-title":"J. Neurophysiol."},{"key":"2023071402282439300_bar02","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0197-4580(02)00008-8","article-title":"Behavioral and neural measures of auditory temporal acuity in aging humans and mice","volume":"23","year":"2002","journal-title":"Neurobiol. Aging"},{"key":"2023071402282439300_bow03"},{"key":"2023071402282439300_car98","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1152\/jn.1998.79.5.2603","article-title":"Caudal pontine reticular formation of C57BL\/6J mice: responses to startle stimuli, inhibition by tones, and plasticity","volume":"79","year":"1998","journal-title":"J. Neurophysiol."},{"key":"2023071402282439300_dav74","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1037\/h0036985","article-title":"Sensitization of the rat startle response by noise","volume":"87","year":"1974","journal-title":"J. Comp. Physiol. Psychol."},{"key":"2023071402282439300_dav80"},{"key":"2023071402282439300_ein92","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/0022-510X(92)90147-D","article-title":"Alterations in the contractile properties of motor units within the aging rat medical gastrocnemius","volume":"112","year":"1992","journal-title":"J. Neurol. Sci."},{"key":"2023071402282439300_fer98","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1152\/jn.1998.79.1.51","article-title":"Synaptic inputs of stellate cells in the ventral cochlear nucleus","volume":"79","year":"1998","journal-title":"J. Neurophysiol."},{"key":"2023071402282439300_for95","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0301-0511(94)00959-2","article-title":"Elderly men and women are less responsive to startling noises: N1, P3 and blink evidence","volume":"39","year":"1995","journal-title":"Biol. Psychol."},{"key":"2023071402282439300_ham72","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/0031-9384(72)90341-1","article-title":"Effects of prestimulation on the electromyographic response associated with the acoustic startle reaction in rats","volume":"8","year":"1972","journal-title":"Physiol. Behav."},{"key":"2023071402282439300_hof63","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1126\/science.141.3584.928","article-title":"Startle reaction: Modification by background acoustic stimulation","volume":"141","year":"1963","journal-title":"Science (Washington, DC, U.S.)"},{"key":"2023071402282439300_hof70","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1121\/1.1911919","article-title":"Role of weak signals in acoustic startle","volume":"47","year":"1970","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071402282439300_iso82","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1037\/0735-7036.96.6.945","article-title":"Temporal acuity in auditory function in the rat: reflex inhibition by brief gaps in noise","volume":"96","year":"1982","journal-title":"J. Comp. Physiol. Psychol."},{"key":"2023071402282439300_iso71","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1037\/h0030934","article-title":"Modification of the startle reflex in the rat by changes in the auditory and visual environments","volume":"75","year":"1971","journal-title":"J. Comp. Physiol. Psychol."},{"key":"2023071402282439300_iso98","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1121\/1.424382","article-title":"Changes in temporal acuity with age and with hearing impairment in the mouse: a study of the acoustic startle reflex and its inhibition by brief decrements in noise level","volume":"104","year":"1998","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071402282439300_iso02","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1121\/1.1490352","article-title":"The relative detectability for mice of gaps having different ramp durations at their onset and offset boundaries","volume":"112","year":"2002","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071402282439300_kal93","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0378-5955(93)90229-T","article-title":"Forward masking properties of neurons in the dorsal cochlear nucleus: possible role in the process of echo suppression","volume":"67","year":"1993","journal-title":"Hear. Res."},{"key":"2023071402282439300_kel91","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1037\/0735-7044.105.5.640","article-title":"Modulation of noise-potentiated acoustic startle via the benzodiazepine-gamma-aminobutyric acid receptor complex","volume":"105","year":"1991","journal-title":"Behav. Neurosci."},{"key":"2023071402282439300_kra81","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0163-1047(81)91455-2","article-title":"Sensory-motor function in the aging rat","volume":"31","year":"1981","journal-title":"Behav. Neural Biol."},{"key":"2023071402282439300_kre98","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/00005537-199801000-00005","article-title":"Age-related glycine receptor subunit changes in the cochlear nucleus of Fischer-344 rats","volume":"108","year":"1998","journal-title":"Laryngoscope"},{"key":"2023071402282439300_li91","doi-asserted-by":"crossref","first-page":"827","DOI":"10.3109\/00016489109138418","article-title":"Age-related loss of auditory sensitivity in two mouse genotypes","volume":"111","year":"1991","journal-title":"Acta Oto-Laryngol."},{"key":"2023071402282439300_mil97","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/(SICI)1096-9861(19970317)379:3<455::AID-CNE10>3.0.CO;2-F","article-title":"Alterations of GABAA receptor subunit mRNA levels in the aging Fischer 344 rat inferior colliculus","volume":"379","year":"1997","journal-title":"J. Comp. Neurol."},{"key":"2023071402282439300_mil48","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1121\/1.1906359","article-title":"The perception of short bursts of noise","volume":"20","year":"1948","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071402282439300_par88","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1037\/0735-7044.102.6.881","article-title":"Acoustic startle response in young and aging C57BL\/6J and CBA\/J mice","volume":"102","year":"1988","journal-title":"Behav. Neurosci."},{"key":"2023071402282439300_plo64","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1121\/1.1918946","article-title":"Rate of decay of auditory sensation","volume":"36","year":"1964","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071402282439300_sne00","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1121\/1.428446","article-title":"Relationships among age-related differences in gap detection and word recognition","volume":"107","year":"2000","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071402282439300_sne02","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1121\/1.1487841","article-title":"Word recognition in competing babble and the effects of age, temporal processing, and absolute sensitivity","volume":"112","year":"2002","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071402282439300_sti73","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1037\/h0035056","article-title":"Modification of the rat\u2019s startle reaction by termination of antecedent acoustic signals","volume":"84","year":"1973","journal-title":"J. Comp. Physiol. Psychol."},{"key":"2023071402282439300_tyl82","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1121\/1.388254","article-title":"Psychoacoustic and phonetic temporal processing in normal and hearing-impaired listeners","volume":"72","year":"1982","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071402282439300_von33"},{"key":"2023071402282439300_wal98","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1523\/JNEUROSCI.18-07-02764.1998","article-title":"Age-related alteration in processing of temporal sound features in the auditory midbrain of the CBA mouse","volume":"18","year":"1998","journal-title":"J. Neurosci."},{"key":"2023071402282439300_wic90","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1523\/JNEUROSCI.10-06-01762.1990","article-title":"Delayed, frequency-specific inhibition in the cochlear nuclei of mice: a mechanism for monaural echo suppression","volume":"10","year":"1990","journal-title":"J. Neurosci."},{"key":"2023071402282439300_wil96","first-page":"141","article-title":"Anatomic and physiologic aging: a behavioral neurscience perspective","volume":"7","year":"1996","journal-title":"J. Am. Acad. Audiol."},{"key":"2023071402282439300_wil97","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/(SICI)1096-9861(19970901)385:3<405::AID-CNE5>3.0.CO;2-7","article-title":"Glycine immunoreactivity and receptor binding in the cochlear nucleus of C57BL\/6J and CBA\/CaJ mice: effects of cochlear impairment and aging","volume":"385","year":"1997","journal-title":"J. Comp. Neurol."},{"key":"2023071402282439300_wu88","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/0006-8993(88)90716-0","article-title":"Anatomical distribution and response patterns of reticular neurons active in relation to acoustic startle","volume":"457","year":"1988","journal-title":"Brain Res."},{"key":"2023071402282439300_you83","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1121\/1.389391","article-title":"Reflex inhibition procedures for animal audiometry: A technique for assessing ototoxicity","volume":"73","year":"1983","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071402282439300_zet03","first-page":"50","article-title":"KV3.1 channel expression in the MNTB of old CBA mice","volume":"26","year":"2003","journal-title":"Assoc. Res. Otolaryngol. Abs."}],"container-title":["The Journal of the Acoustical Society of America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.aip.org\/asa\/jasa\/article-pdf\/114\/1\/522\/8092147\/522_1_online.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.aip.org\/asa\/jasa\/article-pdf\/114\/1\/522\/8092147\/522_1_online.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T02:29:25Z","timestamp":1689301765000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.aip.org\/jasa\/article\/114\/1\/522\/543639\/A-diminished-rate-of-physiological-decay-at-noise"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,7,1]]}},"URL":"https:\/\/doi.org\/10.1121\/1.1577553","relation":{},"ISSN":["0001-4966","1520-8524"],"issn-type":[{"value":"0001-4966","type":"print"},{"value":"1520-8524","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2003,7]]},"published":{"date-parts":[[2003,7,1]]}}}