{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T23:31:49Z","timestamp":1781825509860,"version":"3.54.5"},"reference-count":30,"publisher":"Acoustical Society of America (ASA)","issue":"5","content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,5,1]]},"abstract":"<jats:p>Our aim in the present study was to apply extrapolated DPOAE I\/O-functions [J. Acoust. Soc. Am. 111, 1810\u20131818 (2002); 113, 3275\u20133284 (2003)] in neonates in order to investigate their ability to estimate hearing thresholds and to differentiate between middle-ear and cochlear disorders. DPOAEs were measured in neonates after birth (mean age=3.2\u2009days) and 4 weeks later (follow-up) at 11 test frequencies between f2=1.5 and 8 kHz and compared to that found in normal hearing subjects and cochlear hearing loss patients. On average, in a single ear hearing threshold estimation was possible at about 2\/3 of the test frequencies. A sufficient test performance of the approach is therefore suggested. Thresholds were higher at the first measurement compared to that found at the follow-up measurement. Since thresholds varied with frequency, transitory middle ear dysfunction due to amniotic fluid instead of cochlear immaturity is suggested to be the cause for the change in thresholds. DPOAE behavior in the neonate ears differed from that found in the cochlear hearing loss ears. From a simple model it was concluded that the difference between the estimated DPOAE threshold and the DPOAE detection threshold is able to differentiate between sound conductive and cochlear hearing loss.<\/jats:p>","DOI":"10.1121\/1.1853101","type":"journal-article","created":{"date-parts":[[2005,5,2]],"date-time":"2005-05-02T13:34:49Z","timestamp":1115040889000},"page":"2969-2979","update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["Distortion product otoacoustic emissions for hearing threshold estimation and differentiation between middle-ear and cochlear disorders in neonates"],"prefix":"10.1121","volume":"117","author":[{"given":"Thomas","family":"Janssen","sequence":"first","affiliation":[{"name":"Hals-Nasen-Ohrenklinik, Technische Universit\u00e4t M\u00fcnchen, Ismaningerstra\u00dfe 22, D-81675\u2009Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel D.","family":"Gehr","sequence":"additional","affiliation":[{"name":"Hals-Nasen-Ohrenklinik, Technische Universit\u00e4t M\u00fcnchen, Ismaningerstra\u00dfe 22, D-81675\u2009Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Klein","sequence":"additional","affiliation":[{"name":"Hals-Nasen-Ohrenklinik, Technische Universit\u00e4t M\u00fcnchen, Ismaningerstra\u00dfe 22, D-81675\u2009Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Hals-Nasen-Ohrenklinik, Technische Universit\u00e4t M\u00fcnchen, Ismaningerstra\u00dfe 22, D-81675\u2009Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"231","published-online":{"date-parts":[[2005,4,28]]},"reference":[{"key":"2023071308035175300_c15","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0378-5955(98)00073-2","article-title":"A developmental study of distortion product otoacoustic emission (2f1-f2) suppression in humans","volume":"121","year":"1998","journal-title":"Hear. Res."},{"key":"2023071308035175300_c17","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1121\/1.428315","article-title":"Distortion product otoacoustic emission (2f1-f2) amplitude growth in human adults and neonates","volume":"107","year":"2000","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071308035175300_c16","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1121\/1.1388018","article-title":"Maturation of the human cochlear amplifier: Distortion product otoacoustic emission suppression tuning curves recorded at low and high primary tone levels","volume":"110","year":"2001","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071308035175300_c18","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1121\/1.1625930","article-title":"A longitudinal study of distortion product otoacoustic emission ipsilateral suppression and input\/output characteristics in human neonates","volume":"114","year":"2003","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071308035175300_c19","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1121\/1.1590973","article-title":"Maturation of cochlear nonlinearity as measured by distortion product otoacoustic emission suppression growth in humans","volume":"114","year":"2003","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071308035175300_c5","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1121\/1.1460923","article-title":"Pure-tone threshold estimation from extrapolated distortion product otoacoustic emission I\/O-functions in normal and cochlear hearing loss ears","volume":"111","year":"2002","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071308035175300_c20","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0378-5955(00)00064-2","article-title":"The effects of maturation and stimulus parameters on the optimal f2\/f1 ratio of the 2f1-f2 distortion product otoacoustic emission in neonates","volume":"145","year":"2000","journal-title":"Hear. Res."},{"key":"2023071308035175300_c9","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1121\/1.1417524","article-title":"Distortion product otoacoustic emission input\/output functions in normal-hearing and hearing-impaired human ears","volume":"110","year":"2001","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071308035175300_c14","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1097\/00003446-199610000-00004","article-title":"Comparison of distortion product otoacoustic emission (DPOAE) and auditory brain stem response (ABR) traveling wave delay measurements suggests frequency-specific synapse maturation","volume":"17","year":"1996","journal-title":"Ear Hear."},{"key":"2023071308035175300_c11","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.heares.2004.03.018","article-title":"Middle ear and cochlear disorders result in different DPOAE growth behaviour: implications for the differentiation of sound conductive and cochlear hearing loss","volume":"193","year":"2004","journal-title":"Hear. Res."},{"key":"2023071308035175300_c29","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1097\/00003446-200010000-00007","article-title":"Identification of neonatal hearing impairment: distortion product otoacoustic emissions during the perinatal period","volume":"21","year":"2000","journal-title":"Ear Hear."},{"key":"2023071308035175300_c7","doi-asserted-by":"crossref","first-page":"3275","DOI":"10.1121\/1.1570433","article-title":"Further efforts to predict pure-tone thresholds from distortion product otoacoustic emission input\/output functions","volume":"113","year":"2003","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071308035175300_c24","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0378-5955(93)90101-6","article-title":"Effects of atmospheric pressure variation on spontaneous, transiently evoked, and distortion product otoacoustic emissions in normal human ears","volume":"69","year":"1993","journal-title":"Hear. Res."},{"key":"2023071308035175300_c2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1159\/000313163","article-title":"Wachstumsverhalten der distorsionsproduktemissionen bei kochle\u00e4ren h\u00f6rst\u00f6rungen\u201d (\u201cDPOAE growth behavior in cochlear hearing loss\u201d","volume":"5","year":"1995","journal-title":"Otorhinolaryngol. NOVA"},{"key":"2023071308035175300_c3","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1159\/000313208","article-title":"Wachstumsverhalten der distorsionsproduktemissionen bei normaler h\u00f6rfunktion\u201d (\u201cDPOAE growth behavior in normal hearing\u201d","volume":"5","year":"1995","journal-title":"Otorhinolaryngol. NOVA"},{"key":"2023071308035175300_c30","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.1121\/1.423053","article-title":"Growth behavior of the 2f1-f2 distortion product otoacoustic emission in tinnitus","volume":"103","year":"1998","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071308035175300_c4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0378-5955(00)00097-6","article-title":"Optimal L1-L2 primary tone level separation remains independent of test frequency in humans","volume":"146","year":"2000","journal-title":"Hear. Res."},{"key":"2023071308035175300_c8","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1121\/1.415857","article-title":"Development of the cochlear amplifier","volume":"100","year":"1996","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071308035175300_c22","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0378-5955(98)00079-3","article-title":"Development of the base of the cochlea: place code shift in the gerbil","volume":"122","year":"1998","journal-title":"Hear. Res."},{"key":"2023071308035175300_c10","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1121\/1.1604122","article-title":"Cochlear compression estimates from measurements of distortion-product otoacoustic emissions","volume":"114","year":"2003","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071308035175300_c23","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3109\/01050399309046026","article-title":"Distortion product otoacoustic emissions. The influence of the middle ear transmission","volume":"22","year":"1993","journal-title":"Scand. Audiol."},{"key":"2023071308035175300_c12","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1078\/0939-3889-00148","article-title":"Weighted DPOAE input\/output-functions: a tool for automatic assessment of hearing loss in clinical application","volume":"13","year":"2003","journal-title":"Z. Med. Phys."},{"key":"2023071308035175300_c28","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1159\/000068997","article-title":"The neonate has a temporary conductive hearing loss due to fluid in the middle ear","volume":"8","year":"2003","journal-title":"Audiol. Neuro-Otol."},{"key":"2023071308035175300_c6","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1121\/1.418265","article-title":"Basilar-membrane responses to tones at the base of the chinchilla cochlea","volume":"101","year":"1997","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071308035175300_c13","first-page":"2589","article-title":"Ear-canal standing waves and high-frequency sound calibration using otoacoustic emissions probes","volume":"195","year":"1994","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071308035175300_c27","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1046\/j.1365-2273.2000.00377.x","article-title":"The effects of chronic otitis media with effusion on the measurements of distortion products of otoacoustic emissions: presurgical and postsurgical examination","volume":"25","year":"2000","journal-title":"Clin. Otolaryngol."},{"key":"2023071308035175300_c26","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0378-5955(98)00084-7","article-title":"Effects of effusion in the middle ear and perforation of the tympanic membrane on otoacoustic emissions in guinea pigs","volume":"122","year":"1998","journal-title":"Hear. Res."},{"key":"2023071308035175300_c21","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1121\/1.1675819","article-title":"Development of f2\/f1 ratio functions in humans","volume":"115","year":"2004","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071308035175300_c1","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1121\/1.411960","article-title":"Dependence of distortion-product otoacoustic emissions on primary levels in normal and impaired ears: II. Asymmetry in the L1, L2 space","volume":"97","year":"1995","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071308035175300_c25","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0378-5955(97)00118-4","article-title":"Effect of anesthetic agents and middle ear pressure application on distortion product otoacoustic emissions in the gerbil","volume":"112","year":"1997","journal-title":"Hear. Res."}],"container-title":["The Journal of the Acoustical Society of America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.aip.org\/asa\/jasa\/article-pdf\/117\/5\/2969\/12242445\/2969_1_online.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.aip.org\/asa\/jasa\/article-pdf\/117\/5\/2969\/12242445\/2969_1_online.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T08:59:49Z","timestamp":1689238789000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.aip.org\/jasa\/article\/117\/5\/2969\/539568\/Distortion-product-otoacoustic-emissions-for"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4,28]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,5,1]]}},"URL":"https:\/\/doi.org\/10.1121\/1.1853101","relation":{},"ISSN":["0001-4966","1520-8524"],"issn-type":[{"value":"0001-4966","type":"print"},{"value":"1520-8524","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2005,5]]},"published":{"date-parts":[[2005,4,28]]}}}