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The negative damping mechanism relies on glottal aerodynamics or acoustics to establish before onset and maintain after onset the favorable phase relationship, and therefore has minimum requirements on vocal fold geometry and biomechanics. A single degree-of-freedom vocal fold model is all that is needed for self-oscillation in the presence of a negative damping mechanism. In contrast, the mechanism of eigenmode synchronization critically depends on the geometrical and biomechanical properties of the vocal folds (at least 2-degrees-of-freedom are required), and has little requirement on the glottal aerodynamics other than flow separation. The favorable phase relation is established once synchronization occurs, regardless of the phase relationship imposed by glottal aerodynamics before onset. Unlike that of the negative damping mechanism, initiation of eigenmode synchronization requires neither a velocity-dependent flow pressure nor an alternating convergent-divergent glottis. The clinical implications of the distinctions between these two mechanisms are discussed.<\/jats:p>","DOI":"10.1121\/1.3543989","type":"journal-article","created":{"date-parts":[[2011,4,9]],"date-time":"2011-04-09T00:58:02Z","timestamp":1302310682000},"page":"2163-2167","update-policy":"http:\/\/dx.doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["On the difference between negative damping and eigenmode synchronization as two phonation onset mechanisms"],"prefix":"10.1121","volume":"129","author":[{"given":"Zhaoyan","family":"Zhang","sequence":"first","affiliation":[{"name":"UCLA School of Medicine, 31-24 Rehabilitation Center , 1000 Veteran Avenue, Los Angeles, California 90095-1794"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"231","published-online":{"date-parts":[[2011,4,8]]},"reference":[{"key":"2023073102080213900_c1","doi-asserted-by":"publisher","first-page":"3595","DOI":"10.1121\/1.409875","article-title":"Interpretation of biomechanical simulations of normal and chaotic vocal fold oscillations with empirical eigenfunctions","volume":"95","year":"1994","journal-title":"J. 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