{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:24:54Z","timestamp":1787016294285,"version":"build-2736575974"},"reference-count":43,"publisher":"Acoustical Society of America (ASA)","issue":"5","content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,11,1]]},"abstract":"<jats:p>Tinnitus often develops following inner ear pathologies, like acoustic trauma. Therefore, an acoustic trauma model of tinnitus in gerbils was established using a modulated acoustic startle response. Cochlear trauma evoked by exposure to narrow-band noise at 10 kHz was assessed by auditory brainstem responses (ABR) and distortion product otoacoustic emissions (DPOAE). Threshold shift amounted to about 25 dB at frequencies &amp;gt;\u200910 kHz. Induction of a phantom-noise perception was documented by an acoustic startle response paradigm. A reduction of the gap-prepulse inhibition of acoustic startle (GPIAS) was taken as evidence for tinnitus at the behavioral level. Three to five weeks after trauma the ABR and DPOAE thresholds were back to normal. At that time, a reduction of GPIAS in the frequency range 16\u201320 kHz indicated a phantom noise perception. Seven weeks post trauma the tinnitus-affected frequency range became narrow and shifted to the center-trauma frequency at 10 kHz. Taken together, by investigating frequency-dependent effects in detail, this study in gerbils found trauma-evoked tinnitus developing in the frequency range bordering the low frequency slope of the induced noise trauma. This supports the theory of lateral inhibition as the physiological basis of tinnitus.<\/jats:p>","DOI":"10.1121\/1.3646902","type":"journal-article","created":{"date-parts":[[2011,11,17]],"date-time":"2011-11-17T05:48:38Z","timestamp":1321508918000},"page":"2827-2834","update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":33,"title":["Characterization of the perceived sound of trauma-induced tinnitus in gerbils"],"prefix":"10.1121","volume":"130","author":[{"given":"Manuela","family":"Nowotny","sequence":"first","affiliation":[{"name":"Goethe University Frankfurt am Main Institute of Cell Biology and Neuroscience, Siesmayerstrasse 70A, , D-60323 Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Remus","sequence":"additional","affiliation":[{"name":"Goethe University Frankfurt am Main Institute of Cell Biology and Neuroscience, Siesmayerstrasse 70A, , D-60323 Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"K\u00f6ssl","sequence":"additional","affiliation":[{"name":"Goethe University Frankfurt am Main Institute of Cell Biology and Neuroscience, Siesmayerstrasse 70A, , D-60323 Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard H.","family":"Gaese","sequence":"additional","affiliation":[{"name":"Goethe University Frankfurt am Main Institute of Cell Biology and Neuroscience, Siesmayerstrasse 70A, , D-60323 Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"231","published-online":{"date-parts":[[2011,11,16]]},"reference":[{"key":"2023072809494571300_c1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s101620010030","article-title":"Assessing tinnitus and prospective tinnitus therapeutics using a psychophysical animal model","volume":"2","year":"2001","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"2023072809494571300_c42","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1002\/jnr.21699","article-title":"Tinnitus and inferior colliculus activity in chinchillas related to three distinct patterns of cochlear trauma","volume":"86","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"2023072809494571300_c2","doi-asserted-by":"publisher","first-page":"2948","DOI":"10.1121\/1.1513364","article-title":"\u201cSusceptibility to acoustic trauma in young and aged gerbils,\u201d","volume":"112","year":"2002","journal-title":"J. Acoust. Soc. Am."},{"key":"2023072809494571300_c3","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1044\/1092-4388(2002\/100)","article-title":"\u201cPresbyacusis and the auditory brainstem response!,\u201d","volume":"45","year":"2002","journal-title":"J. Speech Lang. Hear. Res."},{"key":"2023072809494571300_c4","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1121\/1.386906","article-title":"Acoustic trauma: single neuron basis for the \u201chalf-octave shift","volume":"70","year":"1981","journal-title":"J. Acoust. Soc. Am."},{"key":"2023072809494571300_c5","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/978-1-4899-2286-1","article-title":"The mammalian startle response","volume-title":"Neural Mechanisms of Startle Behavior","author":"Eaton","year":"1984"},{"key":"2023072809494571300_c6","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1111\/j.1460-9568.2010.07183.x","article-title":"Acoustic trauma evokes hyperactivity and changes in gene expression in guinea-pig auditory brainstem","volume":"31","year":"2010","journal-title":"Eur. J. Neurosci."},{"key":"2023072809494571300_c7","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.heares.2007.10.003","article-title":"Strain-dependence of age-related cochlear hearing loss in wild and domesticated Mongolian gerbils","volume":"235","year":"2008","journal-title":"Hear. Res."},{"key":"2023072809494571300_c9","doi-asserted-by":"publisher","first-page":"S7","DOI":"10.1016\/S0385-8146(02)00122-0","article-title":"\u201cCentral tinnitus,\u201d","volume":"30","year":"2003","journal-title":"Auris Nasus Larynx."},{"key":"2023072809494571300_c10","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/j.tins.2004.08.010","article-title":"The neuroscience of tinnitus","volume":"27","year":"2004","journal-title":"Trend Neurosci."},{"key":"2023072809494571300_c8","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/nature09656","article-title":"Reversing pathological neural activity using targeted plasticity","volume":"470","year":"2011","journal-title":"Nature"},{"key":"2023072809494571300_c11","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/S0378-5955(99)00189-6","article-title":"\u201cEvidence for multiple DPOAE components based upon group delay of the 2f(1)-f(2) distortion in the gerbil,\u201d","volume":"140","year":"2000","journal-title":"Hear. Res."},{"key":"2023072809494571300_c12","doi-asserted-by":"publisher","first-page":"1884","DOI":"10.1121\/1.2770548","article-title":"Differential reductions in acoustic startle document the discrimination of speech sounds in rats","volume":"122","year":"2007","journal-title":"J. Acoust. Soc. Am."},{"key":"2023072809494571300_c13","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.physbeh.2010.05.009","article-title":"Effects of damage to auditory cortex on the discrimination of speech sounds by rats","volume":"101","year":"2010","journal-title":"Physiol. Behav."},{"key":"2023072809494571300_c14","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.physbeh.2009.07.014","article-title":"Acoustic startle and prepulse inhibition in the Mongolian gerbil","volume":"98","year":"2009","journal-title":"Physiol. Behav."},{"key":"2023072809494571300_c15","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0378-5955(96)80009-8","article-title":"\u201cCentral tinnitus and lateral inhibition: an auditory brainstem model,\u201d","volume":"97","year":"1996","journal-title":"Hear. Res."},{"key":"2023072809494571300_c16","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S0378-5955(02)00343-X","article-title":"Tinnitus in hamsters following exposure to intense sound","volume":"170","year":"2002","journal-title":"Hear. Res."},{"key":"2023072809494571300_c17","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/S0030-6665(02)00160-3","article-title":"\u201cClassification and epidemiology of tinnitus,\u201d","volume":"36","year":"2003","journal-title":"Otolaryngol. Clin. North. Am."},{"key":"2023072809494571300_c18","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/978-0-387-72561-1","article-title":"The patterns and mechanisms of noise-induced cochlear pathology","volume-title":"Auditory Trauma, Protection, and Repair, Springer Handbook of Auditory Research","author":"Schacht","year":"2008"},{"key":"2023072809494571300_c19","first-page":"204","article-title":"Tinnitus: Surgical treatment","volume":"85","year":"1981","journal-title":"Ciba Found. Symp."},{"key":"2023072809494571300_c20","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1097\/00001756-200203250-00016","article-title":"Lateral inhibition in the auditory cortex: An EEG index of tinnitus?","volume":"13","year":"2002","journal-title":"Neuroreport."},{"key":"2023072809494571300_c21","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S0301-0082(98)00098-7","article-title":"\u201cThe neurobiology of startle,\u201d","volume":"59","year":"1999","journal-title":"Prog. Neurobiol."},{"key":"2023072809494571300_c22","doi-asserted-by":"publisher","first-page":"14077","DOI":"10.1523\/JNEUROSCI.2845-09.2009","article-title":"Adding insult to injury: Cochlear nerve degeneration after \u201ctemporary\u201d noise-induced hearing loss","volume":"29","year":"2009","journal-title":"J. Neurosci."},{"key":"2023072809494571300_c23","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1080\/03655230600895408","article-title":"Salicylate- and quinine-induced tinnitus and effects of memantine","volume":"556","year":"2006","journal-title":"Acta Otolaryngol."},{"key":"2023072809494571300_c24","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1121\/1.1535942","article-title":"\u201cDifferential responses to acoustic damage and furosemide in auditory brainstem and otoacoustic emission measures,\u201d","volume":"113","year":"2003","journal-title":"J. Acoust. Soc. Am."},{"key":"2023072809494571300_c25","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/S0378-5955(01)00390-2","article-title":"Behavioural measurement of level-dependent shifts in the vibration pattern on the basilar membrane","volume":"163","year":"2002","journal-title":"Hear. Res."},{"key":"2023072809494571300_c26","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1016\/j.neubiorev.2010.11.003","article-title":"\u201cAn integrative model of tinnitus based on a central gain controlling neural sensitivity,\u201d","volume":"35","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"key":"2023072809494571300_c43","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.neubiorev.2010.11.003","article-title":"\u201cNeural changes in the auditory cortex of awake guinea pigs after two tinnitus inducers: salicylate and acoustic trauma,\u201d","volume":"166","year":"2010","journal-title":"Neurosci."},{"key":"2023072809494571300_c27","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1073\/pnas.0911268107","article-title":"Listening to tailor-made notched music reduces tinnitus loudness and tinnitus-related auditory cortex activity","volume":"107","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2023072809494571300_c28","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1097\/MAO.0b013e3181de4662","article-title":"Comparison of salicylate- and quinine-induced tinnitus in rats: development, time course, and evaluation of audiologic correlates","volume":"31","year":"2010","journal-title":"Otol. Neurotol."},{"key":"2023072809494571300_c29","doi-asserted-by":"publisher","first-page":"14972","DOI":"10.1523\/JNEUROSCI.4028-10.2010","article-title":"Ringing ears: The neuroscience of tinnitus","volume":"30","year":"2010","journal-title":"J. Neurosci."},{"key":"2023072809494571300_c30","first-page":"329","article-title":"The effect of intense acoustic stimulation on basilar-membrane vibrations","volume":"2","year":"1996","journal-title":"Auditory Neurosci."},{"key":"2023072809494571300_c31","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S0378-5955(03)00075-3","article-title":"A behavioral paradigm to judge acute sodium salicylate-induced sound experience in rats: a new approach for an animal model on tinnitus","volume":"180","year":"2003","journal-title":"Hear. Res."},{"key":"2023072809494571300_c32","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1121\/1.380961","article-title":"\u201cHearing sensitivity of the mongolian gerbil, Meriones unguiculatus,\u201d","volume":"59","year":"1976","journal-title":"J. Acoust. Soc. Am."},{"key":"2023072809494571300_c33","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1007\/978-1-60761-145-5","article-title":"A global brain model of tinnitus","volume-title":"Textbook of Tinnitus","author":"M\u00f8ller","year":"2011"},{"key":"2023072809494571300_c34","first-page":"42","article-title":"Inner ear pathology and tinnitus","volume-title":"Proceedings if the Third International Tinnitus Seminar","author":"Feldmann","year":"1987"},{"key":"2023072809494571300_c35","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.neuroscience.2008.12.024","article-title":"Salicylate increases the gain of the central auditory system","volume":"159","year":"2009","journal-title":"Neuroscience"},{"key":"2023072809494571300_c36","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1037\/0735-7044.120.1.188","article-title":"Gap detection deficits in rats with tinnitus: a potential novel screening tool","volume":"120","year":"2006","journal-title":"Behav. Neurosci."},{"key":"2023072809494571300_c37","doi-asserted-by":"publisher","first-page":"S185","DOI":"10.1044\/1059-0889(2008\/08-0006)","article-title":"Gap detection methods for assessing salicylate-induced tinnitus and hyperacusis in rats","volume":"17","year":"2008","journal-title":"Am. J. Audiol."},{"key":"2023072809494571300_c38","doi-asserted-by":"publisher","first-page":"459","DOI":"10.2174\/1566524033479627","article-title":"Neurodevelopmental animal models of schizophrenia: Effects on prepulse inhibition","volume":"3","year":"2003","journal-title":"Curr. Mol. Med."},{"key":"2023072809494571300_c39","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.neuroscience.2009.08.026","article-title":"Plasticity at glycinergic synapses in dorsal cochlear nucleus of rats with behavioral evidence of tinnitus","volume":"164","year":"2009","journal-title":"Neurosci."},{"key":"2023072809494571300_c40","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.heares.2006.06.013","article-title":"Salicylate induced tinnitus: behavioral measures and neural activity in auditory cortex of awake rats","volume":"226","year":"2007","journal-title":"Hear. Res."},{"key":"2023072809494571300_c41","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1121\/1.1336503","article-title":"A phenomenological model for the responses of auditory-nerve fibers: I. Nonlinear tuning with compression and suppression","volume":"109","year":"2001","journal-title":"J. Acoust. Soc. Am."}],"container-title":["The Journal of the Acoustical Society of America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.aip.org\/asa\/jasa\/article-pdf\/130\/5\/2827\/15297526\/2827_1_online.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.aip.org\/asa\/jasa\/article-pdf\/130\/5\/2827\/15297526\/2827_1_online.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,14]],"date-time":"2024-04-14T16:24:19Z","timestamp":1713111859000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.aip.org\/jasa\/article\/130\/5\/2827\/843243\/Characterization-of-the-perceived-sound-of-trauma"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,1]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,11,1]]}},"URL":"https:\/\/doi.org\/10.1121\/1.3646902","relation":{},"ISSN":["0001-4966","1520-8524"],"issn-type":[{"value":"0001-4966","type":"print"},{"value":"1520-8524","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2011,11]]},"published":{"date-parts":[[2011,11,1]]}}}