{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:30:54Z","timestamp":1790695854838,"version":"4.1.0"},"reference-count":33,"publisher":"Acoustical Society of America (ASA)","issue":"6","content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1997,6,1]]},"abstract":"<jats:p>The CBA mouse shows little evidence of hearing loss until late in life, whereas the C57BL\/6 strain develops a severe and progressive, high-frequency sensorineural hearing loss beginning around 3\u20136 months of age. These functional differences have been linked to genetic differences in the amount of hair cell loss as a function of age; however, a precise, quantitative description of the sensory cell loss is unavailable. The present study provides mean values of inner hair cell (IHC) and outer hair cell (OHC) loss for CBA and C57BL\/6 mice at 1, 3, 8, 18, and 26 months of age. CBA mice showed little evidence of hair cell loss until 18 months of age. At 26 months of age, OHC losses in the apex and base of the cochlea were approximately 65% and 50%, respectively, and IHC losses were approximately 25% and 35%. By contrast, C57BL\/6 mice showed approximately a 75% OHC and a 55% IHC loss in the base of the cochlea at 3 months of age. OHC and IHC losses increased rapidly with age along a base-to-apex gradient. By 26 months of age, more than 80% of the OHCs were missing throughout the entire cochlea; however, IHC losses ranged from 100% near the base of the cochlea to approximately 20% in the apex.<\/jats:p>","DOI":"10.1121\/1.418315","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:03:08Z","timestamp":1027677788000},"page":"3546-3553","update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":268,"title":["Quantitative measures of hair cell loss in CBA and C57BL\/6 mice throughout their life spans"],"prefix":"10.1121","volume":"101","author":[{"given":"Vlasta P.","family":"Spongr","sequence":"first","affiliation":[{"name":"Hearing Research Laboratory, Department of Communicative Disorders and Sciences, 215 Parker Hall, SUNY at Buffalo, Buffalo, New York 14214"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothy G.","family":"Flood","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Frisina","sequence":"additional","affiliation":[{"name":"Otolaryngology Division, Surgery Department, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642-8629"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Salvi","sequence":"additional","affiliation":[{"name":"Hearing Research Lab, 215 Parker Hall, SUNY at Buffalo, Buffalo, New York 14214"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"231","reference":[{"key":"2023070915521660700_boe","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0378-5955(92)90189-T","article-title":"Physiological and histological changes associated with the reduction in threshold shift during interrupted noise exposure","volume":"62","year":"1992","journal-title":"Hearing Res."},{"key":"2023070915521660700_boh","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0378-5955(90)90200-9","article-title":"Morphological correlates of aging in the chinchilla cochlea","volume":"48","year":"1990","journal-title":"Hearing Res."},{"key":"2023070915521660700_cho"},{"key":"2023070915521660700_ehr","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/BF01464344","article-title":"Frequency and intensity discrimination limen and nonlinearities in the ear of the house mouse (Mus Musculus)","volume":"102","year":"1975","journal-title":"J. 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