{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:09:56Z","timestamp":1773306596207,"version":"3.50.1"},"reference-count":35,"publisher":"Acoustical Society of America (ASA)","issue":"3","content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1998,3,1]]},"abstract":"<jats:p>Resistance to noise-induced hearing loss (NIHL) was studied in gerbils exposed either to intermittent or continuous low-level noise prior to an intense noise. Auditory-evoked brainstem response (ABR) thresholds, distortion product otoacoustic emissions (DPOAEs), Q10\u2009dB values from compound action potential (CAP) tuning curves, and outer hair cell (OHC) loss were measured for each group. Subjects were exposed to A-weighted noise (octave band noise centered at 2 kHz) on an intermittent (80 dB, 6 h\/day) or continuous schedule (74 dB, 24 h\/day) for 10 days, allowed to rest in quiet for 2 days, then exposed to intense A-weighted noise (107 dB, 24 h\/day) for 2 days. A \u201cnoise-only\u201d group was exposed only to the intense noise. Gerbils exposed in both the \u201cintermittent\u201d and \u201ccontinuous\u201d groups had less (15\u201330 dB) temporary threshold shift (TTS) than those in the noise-only group. In addition, the continuous group had less (10\u201315 dB) permanent threshold shift (PTS) than the other groups. These data suggest that resistance to NIHL is evident in both the intermittent and continuous groups when TTS is measured, but resistance to PTS is afforded only by the continuous paradigm. Both paradigms decreased OHC loss as compared to the noise-only group, with the continuous paradigm being most effective. However, neither paradigm conserved DPOAE amplitudes or tuning curve Q10\u2009dB values relative to the noise-only group.<\/jats:p>","DOI":"10.1121\/1.421303","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:03:47Z","timestamp":1027692227000},"page":"1566-1572","update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":31,"title":["Effectiveness of intermittent and continuous acoustic stimulation in preventing noise-induced hearing and hair cell loss"],"prefix":"10.1121","volume":"103","author":[{"given":"David R.","family":"White","sequence":"first","affiliation":[{"name":"Department of Otolaryngology and Communicative Sciences, Medical University of South Carolina, Charleston, South Carolina\u200929425-2242"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flint A.","family":"Boettcher","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Communicative Sciences, Medical University of South Carolina, Charleston, South Carolina\u200929425-2242"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lesa R.","family":"Miles","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Communicative Sciences, Medical University of South Carolina, Charleston, South Carolina\u200929425-2242"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael Anne","family":"Gratton","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Communicative Sciences, Medical University of South Carolina, Charleston, South Carolina\u200929425-2242"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"231","reference":[{"key":"2023071400414403600_axe","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1177\/000348947408300417","article-title":"Studies of cochlear vasculature and sensory structures: A modified method","volume":"83","year":"1974","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"2023071400414403600_bo93","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1121\/1.407226","article-title":"Auditory brain-stem response correlates of resistance to noise-induced hearing loss in the Mongolian gerbil","volume":"94","year":"1993","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071400414403600_bo96","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1097\/00005537-199606000-00020","article-title":"Diltiazem does not protect the ear from noise-induced hearing loss in mongolian gerbils","volume":"106","year":"1996","journal-title":"Laryngoscope"},{"key":"2023071400414403600_bg93"},{"key":"2023071400414403600_bo95","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1121\/1.413811","article-title":"Distortion-product otoacoustic emissions in Mongolian gerbils with resistance to noise-induced hearing loss","volume":"98","year":"1995","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071400414403600_bo92","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0378-5955(92)90189-T","article-title":"Physiological and histological changes associated with the reduction in threshold shift during interrupted noise exposure","volume":"62","year":"1992","journal-title":"Hearing Res."},{"key":"2023071400414403600_boh5","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1177\/000348948509400205","article-title":"Damage to the cochlea following interrupted exposure to low frequency noise","volume":"94","year":"1985","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"2023071400414403600_boh7","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0378-5955(87)90172-9","article-title":"Cochlear damage following interrupted exposure to high-frequency noise","volume":"29","year":"1987","journal-title":"Hearing Res."},{"key":"2023071400414403600_cam","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0378-5955(91)90104-H","article-title":"The effect of \u2018conditioning\u2019 exposures on hearing loss from traumatic exposure","volume":"55","year":"1991","journal-title":"Hearing Res."},{"key":"2023071400414403600_ca96"},{"key":"2023071400414403600_ca88","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0378-5955(88)90107-4","article-title":"Protection against noise trauma by preexposure to a low level acoustic stimulus","volume":"34","year":"1988","journal-title":"Hearing Res."},{"key":"2023071400414403600_ca92"},{"key":"2023071400414403600_ca93","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0304-3940(93)90118-5","article-title":"Ultrastructural changes in the presynaptic region of outer hair cells after acoustic stimulation","volume":"150","year":"1993","journal-title":"Neurosci. Lett."},{"key":"2023071400414403600_cla","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1121\/1.395261","article-title":"Effect of periodic rest on hearing loss and cochlear damage following exposure to noise","volume":"82","year":"1987","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071400414403600_dal","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1121\/1.380903","article-title":"Compound action potential (AP) tuning curves","volume":"59","year":"1976","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071400414403600_dav","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-5955(89)90173-1","article-title":"The relation among hearing loss, sensory cell loss, and tuning characteristics in the chinchilla","volume":"41","year":"1989","journal-title":"Hearing Res."},{"key":"2023071400414403600_fra","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0378-5955(91)90053-C","article-title":"Altered susceptibility of 2\u2009f1-f2 acoustic-distortion products to the effects of repeated noise exposure in rabbits","volume":"53","year":"1991","journal-title":"Hearing Res."},{"key":"2023071400414403600_gra","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0378-5955(90)90046-R","article-title":"Interaction of cisplatin and noise on the peripheral auditory system","volume":"50","year":"1990","journal-title":"Hearing Res."},{"key":"2023071400414403600_ham","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1121\/1.416285","article-title":"The cubic distortion product otoacoustic emissions from the normal and noise-damaged chinchilla cochlea","volume":"100","year":"1996","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071400414403600_hend","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/0378-5955(94)90172-4","article-title":"The role of middle ear muscles in the development of resistance to noise induced hearing loss","volume":"74","year":"1994","journal-title":"Hearing Res."},{"key":"2023071400414403600_hens","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-5955(94)90038-8","article-title":"The effect of \u2018conditioning\u2019 exposures on hearing loss from impulse noise","volume":"78","year":"1994","journal-title":"Hearing Res."},{"key":"2023071400414403600_kuj"},{"key":"2023071400414403600_mcf","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0378-5955(96)00170-0","article-title":"Low-frequency \u2018conditioning\u2019 provides long-term protection from noise-induced threshold shifts in chinchillas","volume":"103","year":"1997","journal-title":"Hearing Res."},{"key":"2023071400414403600_mil","first-page":"1","article-title":"Deafening effects of noise on the cat","volume":"176","year":"1963","journal-title":"Acta Oto-Laryngol. Suppl."},{"key":"2023071400414403600_rya","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0378-5955(94)90201-1","article-title":"Protection from noise-induced hearing loss by prior exposure to a nontraumatic stimulus: Role of the middle ear muscles","volume":"72","year":"1994","journal-title":"Hearing Res."},{"key":"2023071400414403600_sc84","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1121\/1.391446","article-title":"Acoustic injury and the physiology of hearing","volume":"76","year":"1984","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071400414403600_sc86","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1121\/1.393675","article-title":"Acoustic distortion in the ear canal. I. Cubic difference tones: Effects on acute noise injury","volume":"79","year":"1986","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071400414403600_sin","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1121\/1.395829","article-title":"Effect of periodic rest on physiological measures of auditory sensitivity following exposure to noise","volume":"82","year":"1987","journal-title":"J. Acoust. Soc. Am."},{"key":"2023071400414403600_smi"},{"key":"2023071400414403600_su91","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0378-5955(91)90197-H","article-title":"The effect of exposure level on the development of progressive resistance to noise","volume":"52","year":"1991","journal-title":"Hearing Res."},{"key":"2023071400414403600_su92","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0378-5955(92)90008-B","article-title":"The effect of \u2018conditioning\u2019 on hearing loss from a high frequency traumatic exposure","volume":"58","year":"1992","journal-title":"Hearing Res."},{"key":"2023071400414403600_su95"},{"key":"2023071400414403600_su94","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/0378-5955(94)90188-0","article-title":"Changes in distortion product otoacoustic emissions and outer hair cells following interrupted noise exposures","volume":"74","year":"1994","journal-title":"Hearing Res."},{"key":"2023071400414403600_tar","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0378-5955(91)90142-V","article-title":"Age-related changes in cochleas of mongolian gerbils","volume":"54","year":"1991","journal-title":"Hearing Res."},{"key":"2023071400414403600_zhe","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0378-5955(96)00187-6","article-title":"The role of the cochlear efferent system in acquired resistance to noise-induced hearing loss","volume":"104","year":"1997","journal-title":"Hearing Res."}],"container-title":["The Journal of the Acoustical Society of America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.aip.org\/asa\/jasa\/article-pdf\/103\/3\/1566\/10678900\/1566_1_online.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.aip.org\/asa\/jasa\/article-pdf\/103\/3\/1566\/10678900\/1566_1_online.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T00:42:10Z","timestamp":1689295330000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.aip.org\/jasa\/article\/103\/3\/1566\/557942\/Effectiveness-of-intermittent-and-continuous"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,3,1]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1998,3,1]]}},"URL":"https:\/\/doi.org\/10.1121\/1.421303","relation":{},"ISSN":["0001-4966","1520-8524"],"issn-type":[{"value":"0001-4966","type":"print"},{"value":"1520-8524","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1998,3]]},"published":{"date-parts":[[1998,3,1]]}}}