{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T23:18:55Z","timestamp":1785194335756,"version":"3.55.0"},"reference-count":67,"publisher":"Acoustical Society of America (ASA)","issue":"6","content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1998,6,1]]},"abstract":"<jats:p>High-resolution hearing threshold and 2\u2009f1\u2212f2 distortion product otoacoustic emission (DP) were measured with the same in-the-ear sound probe and same calibration at 51 frequencies between 500 and 8000 Hz in 39 sensorineural hearing loss ears associated with tinnitus. Using a primary tone setting L1=0.4L2+39 that accounts for the nonlinear interaction of the two primary tones at the DP generation site at f2, DPs were elicited in a wide range from L2=65 to 20 dB SPL. We failed to find a uniform DP behavior in the 39 tinnitus ears tested. Seventeen of them behaved like impaired ears without tinnitus. In these ears a linearized DP growth was observed where the DP level decreased and the slope of the DP I\/O functions steepened with increasing hearing loss and as a result both the DP level and the DP slope strongly correlated with hearing threshold. The other population, 22 tinnitus ears, exhibited a poor or even inverse relationship between DP level and hearing threshold, i.e., displayed an increase of DP level with increasing hearing loss. Despite the severe hearing loss but due to the high level, DPs could be recorded well in the frequency range that corresponded to the appearance of the tinnitus. The DP slope, however, increased with increasing hearing loss and, therefore, did still correlate with hearing threshold revealing pathological alteration. The data suggest that the DP level alone is hardly capable of assessing hearing impairment in tinnitus ears and may even be misleading. Thus just the DP slope seems to be the only reliable indicator of cochlear malfunction around the tinnitus frequency. The observed nonuniform DP behavior suggests different cochlear impairments in tinnitus ears. In those ears where the DP level decreases and the slope of the I\/O functions increases with hearing loss, cochlear sensitivity and tuning are supposed to be diminished. In those ears where the DP level increases with increasing hearing loss, a reinforced mechanical distortion is hypothetized to be generated by cochlear hyperactivity that can be the source of both the abnormally high DP level and the tinnitus.<\/jats:p>","DOI":"10.1121\/1.423053","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:05:41Z","timestamp":1027692341000},"page":"3418-3430","update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":60,"title":["Growth behavior of the 2\u2009f1\u2212f2 distortion product otoacoustic emission in tinnitus"],"prefix":"10.1121","volume":"103","author":[{"given":"Thomas","family":"Janssen","sequence":"first","affiliation":[{"name":"Hals-Nasen-Ohren-Klinik, Technische Universit\u00e4t, Ismaningerstr. 22, 81675\u2009M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kummer","sequence":"additional","affiliation":[{"name":"Hals-Nasen-Ohren-Klinik, Technische Universit\u00e4t, Ismaningerstr. 22, 81675\u2009M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Arnold","sequence":"additional","affiliation":[{"name":"Hals-Nasen-Ohren-Klinik, Technische Universit\u00e4t, Ismaningerstr. 22, 81675\u2009M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"231","reference":[{"key":"2023071410111163500_all"},{"key":"2023071410111163500_att","doi-asserted-by":"crossref","first-page":"534","DOI":"10.3109\/00016489609137885","article-title":"The influence of the efferent auditory system on otoacoustic emission in noise induced tinnitus: Clinical relevance","volume":"116","year":"1996","journal-title":"Acta Oto-Laryngol."},{"key":"2023071410111163500_ava","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3109\/00206099309072924","article-title":"Frequency specificity of human distortion product otoacoustic emissions","volume":"32","year":"1993","journal-title":"Audiology"},{"key":"2023071410111163500_boe","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0196-0709(91)90071-M","article-title":"Salicylate ototoxicity: Review and synthesis","volume":"12","year":"1991","journal-title":"Am. 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