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The effects of time-reversal acoustics-focused ultrasound on the spatial distribution of infused low- and high-molecular weight tracer molecules are examined in live, anesthetized rats. Results show that exposing the rat brain to focused ultrasound significantly increases the penetration of infused compounds into the brain. The addition of stabilized microbubbles enhances the effect of ultrasound exposure.<\/jats:p>","DOI":"10.1121\/1.4812879","type":"journal-article","created":{"date-parts":[[2013,8,2]],"date-time":"2013-08-02T23:09:48Z","timestamp":1375484988000},"page":"1569-1575","update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":25,"title":["Time-reversal acoustics and ultrasound-assisted convection-enhanced drug delivery to the brain"],"prefix":"10.1121","volume":"134","author":[{"given":"William","family":"Olbricht","sequence":"first","affiliation":[{"name":"Cornell University School of Chemical and Biomolecular Engineering and Department of Biomedical Engineering, Olin Hall, , Ithaca, New York 14853"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjari","family":"Sistla","sequence":"additional","affiliation":[{"name":"Cornell University Department of Biomedical Engineering, Weill Hall, , Ithaca, New York 14853"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Ghandi","sequence":"additional","affiliation":[{"name":"Artann Laboratories, Inc. , 1459 Lower Ferry Road, Trenton, New Jersey 08618"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"George","family":"Lewis","sequence":"additional","affiliation":[{"name":"Cornell University Department of Biomedical Engineering, Weill Hall, , Ithaca, New York 14853"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armen","family":"Sarvazyan","sequence":"additional","affiliation":[{"name":"Artann Laboratories, Inc. , 1459 Lower Ferry Road, Trenton, New Jersey 08618"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"231","reference":[{"key":"2023080301260338300_c1","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/scientificamerican1199-91","article-title":"Time reversed acoustics","volume":"281","year":"1999","journal-title":"Sci. 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