{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T11:08:25Z","timestamp":1761217705375},"reference-count":22,"publisher":"Acoustical Society of America (ASA)","issue":"4","content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,4,1]]},"abstract":"<jats:p>A noninvasive test was developed in rabbits based on fast adaptation measures for 2f1-f2 distortion-product otoacoustic emissions (DPOAEs). The goal was to evaluate the effective reflex activation, i.e., \u201cfunctional strength,\u201d of both the descending medial olivocochlear efferent reflex (MOC-R) and the middle-ear muscle reflex (MEM-R) through sound activation. Classically, it is assumed that both reflexes contribute toward protecting the inner ear from cochlear damage caused by noise exposure. The DP-gram method described here evaluated the MOC-R effect on DPOAE levels over a two-octave (oct) frequency range. To estimate the related activation of the middle-ear muscles (MEMs), the MEM-R was measured by monitoring the level of the f1-primary tone throughout its duration. Following baseline measures, rabbits were subjected to noise over-exposure. A main finding was that the measured adaptive activity was highly variable between rabbits but less so between the ears of the same animal. Also, together, the MOC-R and MEM-R tests showed that, on average, DPOAE adaptation consisted of a combined contribution from both systems. Despite this shared involvement, the amount of DPOAE adaptation measured for a particular animal's ear predicted that ear's subsequent susceptibility to the noise over-exposure for alert but not for deeply anesthetized rabbits.<\/jats:p>","DOI":"10.1121\/1.4868389","type":"journal-article","created":{"date-parts":[[2014,4,12]],"date-time":"2014-04-12T00:32:54Z","timestamp":1397262774000},"page":"1941-1949","update-policy":"http:\/\/dx.doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Adaptation of distortion product otoacoustic emissions predicts susceptibility to acoustic over-exposure in alert rabbits"],"prefix":"10.1121","volume":"135","author":[{"given":"Anne E.","family":"Luebke","sequence":"first","affiliation":[{"name":"Departments of Neurobiology and Anatomy and Biomedical Engineering, University of Rochester Medical Center , Rochester, New York 14534"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barden B.","family":"Stagner","sequence":"additional","affiliation":[{"name":"Research Service, Veterans Affairs Loma Linda Healthcare System , Loma Linda, California 92357"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glen K.","family":"Martin","sequence":"additional","affiliation":[{"name":"Research Service, Veterans Affairs Loma Linda Healthcare System , Loma Linda, California 92357"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda L.","family":"Lonsbury-Martin","sequence":"additional","affiliation":[{"name":"Research Service, Veterans Affairs Loma Linda Healthcare System , Loma Linda, California 92357"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"231","reference":[{"key":"2023080405405516800_c1","doi-asserted-by":"publisher","first-page":"335","DOI":"10.3109\/00206099609071954","article-title":"Comparison of response properties of neurons in the inferior colliculus of guinea pigs under different anesthetics","volume":"35","year":"1996","journal-title":"Audiology"},{"key":"2023080405405516800_c2","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1007\/s10162-007-0100-0","article-title":"Measurement of the distribution of medial olivocochlear acoustic reflex strengths across normal-hearing individuals via otoacoustic emissions","volume":"8","year":"2007","journal-title":"J. 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