{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:36:54Z","timestamp":1762659414931},"reference-count":26,"publisher":"Acoustical Society of America (ASA)","issue":"1","content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,7,1]]},"abstract":"<jats:p>Cochlear damage caused by loud sounds can be attenuated by \u201csound-conditioning\u201d methods. The amount of adaptation for distortion product otoacoustic emissions (DPOAEs) measured in alert rabbits previously predicted an ear's susceptibility to a subsequent noise exposure. The present study investigated if sound-conditioning influenced the robustness of such DPOAE adaptation, and if such conditioning elicited more protection by increasing the amount of DPOAE adaptation. Toward this end, rabbits were divided into two study groups: (1) experimental animals exposed to a sound-conditioning protocol, and (2) unconditioned control animals. After base-line measures, all rabbits were exposed to an overstimulation paradigm consisting of an octave band noise, and then re-assessed 3 weeks post-exposure to determine permanent changes in DPOAEs. A major result was that prior sound-conditioning protected reductions in DPOAE levels by an average of 10\u201315\u2009dB. However, DPOAE adaptation decreased with sound-conditioning, so that such conditioning was no longer related to noise-induced reductions in DPOAEs. Together, these findings suggest that sound-conditioning affected neural pathways other than those that likely mediate DPOAE adaptation (e.g., medial olivocochlear efferent and\/or middle-ear muscle reflexes).<\/jats:p>","DOI":"10.1121\/1.4922223","type":"journal-article","created":{"date-parts":[[2015,7,3]],"date-time":"2015-07-03T14:45:56Z","timestamp":1435934756000},"page":"58-64","update-policy":"http:\/\/dx.doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["Influence of sound-conditioning on noise-induced susceptibility of distortion-product otoacoustic emissions"],"prefix":"10.1121","volume":"138","author":[{"given":"Anne E.","family":"Luebke","sequence":"first","affiliation":[{"name":"University of Rochester Medical Center 1 Department of Biomedical Engineering, , Rochester, New York 14642, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barden B.","family":"Stagner","sequence":"additional","affiliation":[{"name":"Veterans Affairs Loma Linda Healthcare System 2 Research Service, , Loma Linda, California 92357, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glen K.","family":"Martin","sequence":"additional","affiliation":[{"name":"Loma Linda University Medical Center 3 Department of Otolaryngology\u2014Head and Neck Surgery, , Loma Linda, California 92354, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda L.","family":"Lonsbury-Martin","sequence":"additional","affiliation":[{"name":"Loma Linda University Medical Center 3 Department of Otolaryngology\u2014Head and Neck Surgery, , Loma Linda, California 92354, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"231","published-online":{"date-parts":[[2015,7,2]]},"reference":[{"key":"2023080101025047200_c1","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1007\/s101620020044","article-title":"Effects of anesthesia on efferent-mediated adaptation of the DPOAE","volume":"3","year":"2002","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"2023080101025047200_c2","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1152\/jn.1998.79.6.3088","article-title":"Single olivocochlear neurons in the guinea pig. II. Response plasticity due to noise conditioning","volume":"79","year":"1998","journal-title":"J. Neurophysiol."},{"key":"2023080101025047200_c4","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/0378-5955(88)90107-4","article-title":"Protection against noise trauma by preexposure to a low level acoustic stimulus","volume":"34","year":"1988","journal-title":"Hear. Res."},{"key":"2023080101025047200_c5","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/S0006-8993(99)02091-0","article-title":"Medial olivocochlear efferent terminals are protected by sound conditioning","volume":"850","year":"1999","journal-title":"Brain Res."},{"key":"2023080101025047200_c6","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/0304-3940(95)11726-D","article-title":"Protection against noise trauma by sound conditioning in the guinea pig appears not to be mediated by the middle ear muscles","volume":"194","year":"1995","journal-title":"Neurosci. Lett."},{"key":"2023080101025047200_c7","doi-asserted-by":"publisher","first-page":"7509","DOI":"10.1523\/JNEUROSCI.5138-14.2015","article-title":"Aging after noise exposure: Acceleration of cochlear synaptopathy in \u2018recovered\u2019 ears","volume":"35","year":"2015","journal-title":"J. Neurosci."},{"key":"2023080101025047200_c8","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/0378-5955(91)90053-C","article-title":"Altered susceptibility of 2f1-f2 acoustic-distortion products to the effects of repeated noise exposure in rabbits","volume":"53","year":"1991","journal-title":"Hear. Res."},{"key":"2023080101025047200_c9","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1152\/jn.1999.82.2.863","article-title":"Long-term sound conditioning enhances cochlear sensitivity","volume":"82","year":"1999","journal-title":"J. Neurophysiol."},{"key":"2023080101025047200_c10","first-page":"1","article-title":"Pathways for protection from noise induced hearing loss","volume":"5","year":"2003","journal-title":"Noise Health"},{"key":"2023080101025047200_c11","doi-asserted-by":"publisher","first-page":"3572","DOI":"10.1121\/1.414956","article-title":"The ipsilaterally evoked olivocochlear reflex causes rapid adaptation of the 2f1-f2 distortion product otoacoustic emission","volume":"99","year":"1996","journal-title":"J. Acoust. Soc. Am."},{"key":"2023080101025047200_c12","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1121\/1.4868389","article-title":"Adaptation of distortion product otoacoustic emissions predicts susceptibility to acoustic over-exposure in alert rabbits","volume":"135","year":"2014","journal-title":"J. Acoust. Soc. Am."},{"key":"2023080101025047200_c13","doi-asserted-by":"publisher","first-page":"2941","DOI":"10.1152\/jn.00596.2003","article-title":"Loss of \u03b1CGRP reduces sound-evoked activity in the cochlear nerve","volume":"90","year":"2003","journal-title":"J. Neurophysiol."},{"key":"2023080101025047200_c15","doi-asserted-by":"publisher","first-page":"5542","DOI":"10.1523\/JNEUROSCI.5027-12.2013","article-title":"Efferent feedback minimizes cochlear neuropathy from moderate noise exposure","volume":"33","year":"2013","journal-title":"J. Neurosci."},{"key":"2023080101025047200_c16","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1121\/1.423340","article-title":"Effects of loop diuretics on the suppression tuning of distortion-product otoacoustic emissions in rabbits","volume":"104","year":"1998","journal-title":"J. Acoust. Soc. Am."},{"key":"2023080101025047200_c17","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/S0378-5955(96)00170-0","article-title":"Low-frequency \u2018conditioning\u2019 provides long-term protection from noise-induced threshold shifts in chinchillas","volume":"103","year":"1997","journal-title":"Hear. Res."},{"key":"2023080101025047200_c18","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/0378-5955(93)90051-2","article-title":"Distortion-product emissions in rabbit: I. Altered susceptibility to repeated pure-tone exposures","volume":"70","year":"1993","journal-title":"Hear. Res."},{"key":"2023080101025047200_c19","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/0378-5955(92)90017-H","article-title":"Effect of low level acoustic stimulation on temporary threshold shift in young humans","volume":"60","year":"1992","journal-title":"Hear. Res."},{"key":"2023080101025047200_c22","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/j.neuroscience.2004.02.023","article-title":"The distribution and the modulation of tyrosine hydroxylase immunoreactivity in the lateral olivocochlear system of the guinea-pig","volume":"125","year":"2004","journal-title":"Neuroscience"},{"key":"2023080101025047200_c20","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/S0378-5955(02)00646-9","article-title":"Activation of tyrosine hydroxylase in the lateral efferent terminals by sound conditioning","volume":"174","year":"2002","journal-title":"Hear. Res."},{"key":"2023080101025047200_c21","first-page":"96","article-title":"Protective mechanisms of sound conditioning","volume":"59","year":"2002","journal-title":"Adv. Otorhinolaryngol."},{"key":"2023080101025047200_c24","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1159\/000080226","article-title":"Protection against acoustic trauma by forward and backward sound conditioning","volume":"9","year":"2004","journal-title":"Audiol. Neurotol."},{"key":"2023080101025047200_c25","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.physbeh.2007.05.020","article-title":"Environmental enrichment to sound activates dopaminergic pathways in the auditory system","volume":"92","year":"2007","journal-title":"Physiol. Behav."},{"key":"2023080101025047200_c26","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1097\/WNR.0b013e32820049a8","article-title":"Long-term sound conditioning increases distortion product otoacoustic emission amplitudes and decreases olivocochlear efferent reflex strength","volume":"18","year":"2007","journal-title":"Neuroreport"},{"key":"2023080101025047200_c27","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1097\/MAO.0b013e3180a726c9","article-title":"Otoacoustic emissions in early noise-induced hearing loss","volume":"28","year":"2007","journal-title":"Otol. Neurotol."},{"key":"2023080101025047200_c28","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1080\/000164801300043848","article-title":"Otoacoustic emissions and medial olivocochlear suppression during auditory nerve recovery from acoustic trauma in humans","volume":"121","year":"2001","journal-title":"Acta Otolaryngol."},{"key":"2023080101025047200_c29","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0378-5955(91)90007-V","article-title":"Effects of the crossed acoustic reflex on distortion-product otoacoustic emissions in awake rabbits","volume":"51","year":"1991","journal-title":"Hear. Res."}],"container-title":["The Journal of the Acoustical Society of America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.aip.org\/asa\/jasa\/article-pdf\/138\/1\/58\/15317140\/58_1_online.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.aip.org\/asa\/jasa\/article-pdf\/138\/1\/58\/15317140\/58_1_online.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T01:03:16Z","timestamp":1690851796000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.aip.org\/jasa\/article\/138\/1\/58\/916469\/Influence-of-sound-conditioning-on-noise-induced"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,1]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,7,1]]}},"URL":"https:\/\/doi.org\/10.1121\/1.4922223","relation":{},"ISSN":["0001-4966","1520-8524"],"issn-type":[{"value":"0001-4966","type":"print"},{"value":"1520-8524","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2015,7]]},"published":{"date-parts":[[2015,7,1]]}}}