{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:45:02Z","timestamp":1791416702802,"version":"4.3.3"},"reference-count":30,"publisher":"Acoustical Society of America (ASA)","issue":"4","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,10,1]]},"abstract":"<jats:p>Sound transmission and resulting airway wall vibration in a complex multiscale viscoelastic model of the subglottal bronchial tree was calculated using a modified one-dimensional (1D) branching acoustic waveguide approach. This is an extension of previous work to enable use of complex airway trees that are partially derived from subject-specific medical images, without the need for self-similarity in the geometric structure. The approach was validated numerically for simplified airway geometries, as well as experimentally by comparison to previous studies. A comprehensive conducting airway tree with about 60\u2009000 branches was then modified to create fibrotic, bronchoconstrictive, and pulmonary infiltrate conditions. The fibrotic case\u2014systemic increase in soft tissue stiffness\u2014increased the Helmholtz resonance frequency due to the increased acoustic impedance. Bronchoconstriction, with geometric changes in small conducting airways, decreased acoustic energy transmission to the peripheral airways due in part to the increased impedance mismatch between airway orders. Pulmonary infiltrate significantly altered the local acoustic field in the affected lobe. Calculation of acoustic differences between healthy versus pathologic cases can be used to enhance the understanding of vibro-acoustic changes correlated to pathology, and potentially provide improved tools for the diagnosis of pulmonary diseases that uniquely alter the acoustics of the airways.<\/jats:p>","DOI":"10.1121\/1.5005497","type":"journal-article","created":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T14:30:48Z","timestamp":1507041048000},"page":"1774-1783","update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["A multiscale analytical model of bronchial airway acoustics"],"prefix":"10.1121","volume":"142","author":[{"given":"Brian","family":"Henry","sequence":"first","affiliation":[{"name":"Richard and Loan Hill Department of Bioengineering, University of Illinois at Chicago , 851 South Morgan Street, MC 063, Chicago, Illinois 60607, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Royston","sequence":"additional","affiliation":[{"name":"Richard and Loan Hill Department of Bioengineering, University of Illinois at Chicago , 851 South Morgan Street, MC 063, Chicago, Illinois 60607, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"231","published-online":{"date-parts":[[2017,10,3]]},"reference":[{"key":"2023072906221054700_c1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1152\/jappl.1994.77.1.441","article-title":"Airway geometry and wall mechanical properties estimated from subglottal input impedance in humans","volume":"77","year":"1994","journal-title":"J. Appl. Physiol."},{"key":"2023072906221054700_c2","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1152\/jappl.1977.43.3.523","article-title":"Airway geometry by analysis of acoustic pulse response measurements","volume":"43","year":"1977","journal-title":"J. Appl. Physiol."},{"key":"2023072906221054700_c3","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1121\/1.382085","article-title":"Acoustic input impedance of excised dog lungs","volume":"64","year":"1978","journal-title":"J. Acoust. Soc. Am."},{"key":"2023072906221054700_c4","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s40169-014-0029-y","article-title":"Lung flute improves symptoms and health status in COPD with chronic bronchitis: A 26 week randomized controlled trial","volume":"3","year":"2014","journal-title":"Clin. Transact. Med."},{"key":"2023072906221054700_c5","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1002\/mrm.21053","article-title":"Magnetic resonance elastography of the lung: Technical feasibility","volume":"56","year":"2006","journal-title":"Magn. Reson. Med."},{"key":"2023072906221054700_c6","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1002\/jmri.22550","article-title":"MR elastography of human lung parenchyma: Technical development, theoretical modeling and in vivo validation","volume":"33","year":"2011","journal-title":"J. Magn. Reson. Imag."},{"key":"2023072906221054700_c7","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1121\/1.1452742","article-title":"Modeling sound transmission through the pulmonary system and chest with application to diagnosis of a collapsed lung","volume":"111","year":"2002","journal-title":"J. Acoust. Soc. Am."},{"key":"2023072906221054700_c8","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1121\/1.2715453","article-title":"Boundary element model for simulating sound propagation and source localization within the lungs","volume":"122","year":"2007","journal-title":"J. Acoust. Soc. Am."},{"key":"2023072906221054700_c9","doi-asserted-by":"publisher","first-page":"021010","DOI":"10.1115\/1.2827358","article-title":"Experimental and computational models for simulating sound propagation within the lungs","volume":"130","year":"2008","journal-title":"ASME J. Vib. Acoust."},{"key":"2023072906221054700_c10","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1007\/s11517-014-1172-8","article-title":"Sound transmission in the chest under surface excitation: An experimental and computational study with diagnostic applications","volume":"52","year":"2014","journal-title":"Med. Biol. Eng. Comput."},{"key":"2023072906221054700_c11","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1121\/1.4890647","article-title":"A comprehensive computational model of sound transmission through the porcine lung","volume":"136","year":"2014","journal-title":"J. Acoust. Soc. Am."},{"key":"2023072906221054700_c12","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1007\/s11517-015-1358-8","article-title":"Sound transmission in porcine thorax through airway insonification","volume":"54","year":"2015","journal-title":"Med. Biol. Eng. Comput."},{"key":"2023072906221054700_c13","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.jsv.2014.11.026","article-title":"Experimental and computational studies of sound transmission in a branching airway network embedded in a compliant viscoelastic medium","volume":"339","year":"2015","journal-title":"J. Sound Vib."},{"key":"2023072906221054700_c14","first-page":"202","article-title":"Cystic diseases","volume-title":"Diffuse Lung Disease: Clinical Features, Pathology, HRCT","year":"2007"},{"key":"2023072906221054700_c15","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1378\/chest.09-1002","article-title":"Incidence, prevalence, and clinical course of idiopathic pulmonary fibrosis: A population-based study","volume":"137","year":"2010","journal-title":"Chest"},{"key":"2023072906221054700_c16","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/978-0-387-78285-0_2","article-title":"Asthma: Pathophysiology and diagnosis","volume-title":"Asthma, Health and Society: A Public Health Perspective","year":"2010"},{"key":"2023072906221054700_c17","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1136\/pmj.79.933.384","article-title":"Pulmonary manifestations of sickle cell disease","volume":"79","year":"2003","journal-title":"Postgrad. Med. J."},{"key":"2023072906221054700_c18","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1378\/chest.120.4.1309","article-title":"Acoustic imaging of the human chest","volume":"120","year":"2001","journal-title":"Chest"},{"key":"2023072906221054700_c19","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.jcp.2016.08.039","article-title":"A 4DCT imaging-based breathing lung model with relative hysteresis","volume":"326","year":"2016","journal-title":"J. Comput. Phys."},{"key":"2023072906221054700_c20","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s10237-016-0838-6","article-title":"Automatic construction of subject-specific human airway geometry including trifurcations based on a CT-segmented airway skeleton and surface","volume":"16","year":"2016","journal-title":"Biomech. Model. Mechanobiol."},{"key":"2023072906221054700_c21","doi-asserted-by":"publisher","first-page":"2310","DOI":"10.1152\/japplphysiol.00520.2004","article-title":"CT-based geometry analysis and finite-element models of the human and ovine bronchial tree","volume":"97","year":"2004","journal-title":"J. Appl. Physiol."},{"key":"2023072906221054700_c22","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1152\/jappl.1956.8.6.587","article-title":"Oscillation mechanics of lungs and chest in man","volume":"8","year":"1956","journal-title":"J. Appl. Physiol."},{"key":"2023072906221054700_c23","year":"2016"},{"key":"2023072906221054700_c24","year":"2016"},{"key":"2023072906221054700_c25","year":"2016"},{"key":"2023072906221054700_c26","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1164\/ajrccm.162.4.9912011","article-title":"Changes in extracellular matrix and tissue viscoelasticity in bleomycin-induced lung fibrosis: Temporal aspects","volume":"162","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2023072906221054700_c27","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1083\/jcb.201004082","article-title":"Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression","volume":"190","year":"2010","journal-title":"J. Cell. Biol."},{"key":"2023072906221054700_c28","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1109\/TBME.2008.2007807","article-title":"Mechanical properties of the respiratory system derived from morphologic insight","volume":"56","year":"2009","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"2023072906221054700_c29","doi-asserted-by":"publisher","first-page":"051012","DOI":"10.1115\/1.4026436","article-title":"Comparison of poroviscoelastic models for sound and vibration in the lungs","volume":"136","year":"2014","journal-title":"ASME J. Vib. Acoust."},{"key":"2023072906221054700_c30","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1152\/jappl.1987.62.4.1349","article-title":"Longitudinal elastic wave propagation in pulmonary parenchyma","volume":"62","year":"1987","journal-title":"J. Appl. Physiol."}],"updated-by":[{"DOI":"10.1121\/1.5027239","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T00:00:00Z","timestamp":1520985600000}}],"container-title":["The Journal of the Acoustical Society of America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.aip.org\/asa\/jasa\/article-pdf\/142\/4\/1774\/15325151\/1774_1_online.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.aip.org\/asa\/jasa\/article-pdf\/142\/4\/1774\/15325151\/1774_1_online.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T06:22:49Z","timestamp":1690611769000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.aip.org\/jasa\/article\/142\/4\/1774\/853146\/A-multiscale-analytical-model-of-bronchial-airway"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,1]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,10,1]]}},"URL":"https:\/\/doi.org\/10.1121\/1.5005497","relation":{"correction":[{"id-type":"doi","id":"10.1121\/1.5027239","asserted-by":"object"}]},"ISSN":["0001-4966","1520-8524"],"issn-type":[{"value":"0001-4966","type":"print"},{"value":"1520-8524","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,10]]},"published":{"date-parts":[[2017,10,1]]}}}