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However, preliminary studies established the rabbit larynx as a potential model of human phonation. This study reports quantitative data on phonation using ex vivo rabbit larynx models to achieve more insight into dependencies of three main components of the phonation process, including airflow, vocal fold dynamics, and the acoustic output. Sustained phonation was induced in 11 ex vivo rabbit larynges. For 414 phonatory conditions, vocal fold vibrations, acoustic, and aerodynamic parameters were analyzed as functions of longitudinal vocal fold pre-stress, applied air flow, and glottal closure insufficiency. Dimensions of the vocal folds were measured and histological data were analyzed. Glottal closure characteristics improved for increasing longitudinal pre-stress and applied airflow. For the subglottal pressure signal only the cepstral peak prominence showed dependency on glottal closure. In contrast, vibrational, acoustic, and aerodynamic parameters were found to be highly dependent on the degree of glottal closure: The more complete the glottal closure during phonation, the better the aerodynamic and acoustic characteristics. Hence, complete or at least partial glottal closure appears to enhance acoustic signal quality. Finally, results validate the ex vivo rabbit larynx as an effective model for analyzing the phonatory process.<\/jats:p>","DOI":"10.1121\/1.5043384","type":"journal-article","created":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T15:46:50Z","timestamp":1531151210000},"page":"142-152","update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["Investigation of phonatory characteristics using <i>ex vivo<\/i> rabbit larynges"],"prefix":"10.1121","volume":"144","author":[{"given":"Michael","family":"D\u00f6llinger","sequence":"first","affiliation":[{"name":"Division for Phoniatrics and Pediatric Audiology, Department of Otorhinolaryngology, Head and Neck Surgery, Medical School 1 , FAU Erlangen-N\u00fcrnberg, Waldstrasse 1, Erlangen, 91054, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Kniesburges","sequence":"additional","affiliation":[{"name":"Division for Phoniatrics and Pediatric Audiology, Department of Otorhinolaryngology, Head and Neck Surgery, Medical School 1 , FAU Erlangen-N\u00fcrnberg, Waldstrasse 1, Erlangen, 91054, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Berry","sequence":"additional","affiliation":[{"name":"Laryngeal Dynamics Laboratory, Division of Head and Neck Surgery, David Geffen School of Medicine at UCLA 2 , 1000 Veteran Avenue, 31-24 Rehab Center, Los Angeles, California 90095-1794, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronika","family":"Birk","sequence":"additional","affiliation":[{"name":"Division for Phoniatrics and Pediatric Audiology, Department of Otorhinolaryngology, Head and Neck Surgery, Medical School 1 , FAU Erlangen-N\u00fcrnberg, Waldstrasse 1, Erlangen, 91054, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olaf","family":"Wendler","sequence":"additional","affiliation":[{"name":"Laboratory for Molecular Biology, Department of Otorhinolaryngology, Head and Neck Surgery, Medical School 3 , FAU Erlangen-N\u00fcrnberg, Waldstrasse 1, Erlangen, 91054, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"D\u00fcrr","sequence":"additional","affiliation":[{"name":"Division for Phoniatrics and Pediatric Audiology, Department of Otorhinolaryngology, Head and Neck Surgery, Medical School 1 , FAU Erlangen-N\u00fcrnberg, Waldstrasse 1, Erlangen, 91054, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Alexiou","sequence":"additional","affiliation":[{"name":"Section of Experimental Oncology and Nanomedicine (SEON), Department of Otorhinolaryngology, Head and Neck Surgery, Medical School 4 , Else Kr\u00f6ner-Fresenius-Stiftung-Professorship, FAU Erlangen-N\u00fcrnberg, Gl\u00fcckstrasse 10a, Erlangen, 91054, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Sch\u00fctzenberger","sequence":"additional","affiliation":[{"name":"Division for Phoniatrics and Pediatric Audiology, Department of Otorhinolaryngology, Head and Neck Surgery, Medical School 1 , FAU Erlangen-N\u00fcrnberg, Waldstrasse 1, Erlangen, 91054, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"231","published-online":{"date-parts":[[2018,7,9]]},"reference":[{"issue":"1","key":"2023072821033941600_c1","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.jvoice.2007.03.007","article-title":"Glottal airflow resistance in excised pig, sheep, and cow larynges","volume":"23","year":"2009","journal-title":"J. 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