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All Schuknecht's types of presbycusis have been identified in existing mouse lines, some favoring hair cell loss while others favor strial degeneration. Although noise exposure generally affects the mouse cochlea in a manner similar to other mammals, mice appear more prone to permanent alterations to hair cells or the organ of Corti than to hair cell loss. Therapeutic compounds may be applied systemically or locally through the tympanic membrane or onto (or through) the round window membrane. The thinness of the mouse cochlear capsule and annular ligament may promote drug entry from the middle ear, although an extremely active middle ear lining may quickly remove most drugs. Preclinical testing of any therapeutic will always require tests in multiple animal models. Mice constitute one model providing supporting evidence for any therapeutic, while genetically engineered mice can test hypotheses about mechanisms.<\/jats:p>","DOI":"10.1121\/1.5132550","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T16:30:59Z","timestamp":1574872259000},"page":"3668-3680","update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":51,"title":["Mouse methods and models for studies in hearing"],"prefix":"10.1121","volume":"146","author":[{"given":"Kevin K.","family":"Ohlemiller","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Central Institute for the Deaf at Washington University School of Medicine, Washington University School of Medicine, Fay and Carl Simons Center for Hearing and Deafness , Saint Louis, Missouri 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"231","published-online":{"date-parts":[[2019,11,27]]},"reference":[{"key":"2023080119261897400_c1","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1097\/MAO.0b013e318192483c","article-title":"Risk factors for hearing loss in US adults: Data from the National Health and Nutrition Examination Survey, 1999 to 2002","volume":"30","year":"2009","journal-title":"Otol. 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