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Thus far, there is no effective treatment of blast-induced tinnitus due to an incomplete understanding of its underlying mechanisms, necessitating development of reliable animal models. This article focuses on recent animal studies using behavioral, electrophysiological, imaging, and pharmacological tools. The mechanisms underlying blast-induced tinnitus are largely similar to those underlying noise-induced tinnitus: increased spontaneous firing rates, bursting, and neurosynchrony, Mn++ accumulation, and elevated excitatory synaptic transmission. The differences mainly lie in the data variability and time course. Noise trauma-induced tinnitus mainly originates from direct peripheral deafferentation at the cochlea, and its etiology subsequently develops along the ascending auditory pathways. Blast trauma-induced tinnitus, on the other hand, results from simultaneous impact on both the peripheral and central auditory systems, and the resultant maladaptive neuroplasticity may also be related to the additional traumatic brain injury. Consequently, the neural correlates of blast-induced tinnitus have different time courses and less uniform manifestations of its neural correlates.<\/jats:p>","DOI":"10.1121\/1.5132551","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T16:30:59Z","timestamp":1574872259000},"page":"3811-3831","update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":22,"title":["Blast-induced tinnitus: Animal models"],"prefix":"10.1121","volume":"146","author":[{"given":"Jinsheng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Wayne State University School of Medicine , 4201 Saint Antoine, Detroit, Michigan 48201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"231","published-online":{"date-parts":[[2019,11,27]]},"reference":[{"key":"2023080420183290500_c1","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/0166-2236(93)90110-8","article-title":"The contribution of the amygdala to normal and abnormal emotional states","volume":"16","year":"1993","journal-title":"Trends Neurosci."},{"key":"2023080420183290500_c2","doi-asserted-by":"publisher","first-page":"315","DOI":"10.3766\/jaaa.20.5.5","article-title":"Tinnitus distress, anxiety, depression, and hearing problems among cochlear implant patients with tinnitus","volume":"20","year":"2009","journal-title":"J. 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