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However, even these approaches must utilize animal studies for validation of function and understanding of mechanisms. Animal research currently focuses on genetic expression profiles since the majority of variants occur in non-coding regions, implying regulatory divergences. Moving forward, it will be important in both human and animal research to define the phenotypes of hearing loss and tinnitus, as well as exposure parameters, in order to extricate genes related to acoustic trauma versus those related to aging. It has become clear that common disorders like acoustic trauma are influenced by large numbers of genes, each with small effects, which cumulatively lead to susceptibility to a disorder. A polygenic risk score, which aggregates these small effect sizes of multiple genes, may offer a more accurate description of risk for NIHL and\/or tinnitus.<\/jats:p>","DOI":"10.1121\/1.5132552","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T16:30:59Z","timestamp":1574872259000},"page":"4007-4019","update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":7,"title":["Untangling the genomics of noise-induced hearing loss and tinnitus: Contributions of <i>Mus musculus<\/i> and <i>Homo sapiens<\/i>"],"prefix":"10.1121","volume":"146","author":[{"given":"Royce E.","family":"Clifford","sequence":"first","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery, University of California School of Medicine 1 , 9500 Gilman Drive, La Jolla, California 92093, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronna","family":"Hertzano","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery, University of Maryland School of Medicine 2 , James T. 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