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Although synaptopathy has been observed in human temporal bones, assessment of this condition in living humans is limited to indirect non-invasive measures such as the auditory brainstem response (ABR). In animal models, synaptopathy is associated with a reduction in ABR wave I amplitude at suprathreshold stimulus levels. Several human studies have explored the relationship between wave I amplitude and tinnitus, with conflicting results. This study investigates the hypothesis that reduced peripheral auditory input due to synaptic\/neuronal loss is associated with tinnitus. Wave I amplitude data from 193 individuals [43 with tinnitus (22%), 150 without tinnitus (78%)], who participated in up to 3 out of 4 different studies, were included in a logistic regression analysis to estimate the relationship between wave I amplitude and tinnitus at a variety of stimulus levels and frequencies. Statistical adjustment for sex and distortion product otoacoustic emissions (DPOAEs) was included. The results suggest that smaller wave I amplitudes and\/or lower DPOAE levels are associated with an increased probability of tinnitus.<\/jats:p>","DOI":"10.1121\/1.5132708","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T11:30:59Z","timestamp":1574854259000},"page":"3849-3862","update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":47,"title":["Auditory brainstem response demonstrates that reduced peripheral auditory input is associated with self-report of tinnitus"],"prefix":"10.1121","volume":"146","author":[{"given":"Naomi F.","family":"Bramhall","sequence":"first","affiliation":[{"name":"Department of Veterans Affairs (VA) Rehabilitation Research and Development Service (RR&D), National Center for Rehabilitative Auditory Research (NCRAR), VA Portland Health Care System , Portland, Oregon 97239, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garnett P.","family":"McMillan","sequence":"additional","affiliation":[{"name":"Department of Veterans Affairs (VA) Rehabilitation Research and Development Service (RR&D), National Center for Rehabilitative Auditory Research (NCRAR), VA Portland Health Care System , Portland, Oregon 97239, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick J.","family":"Gallun","sequence":"additional","affiliation":[{"name":"Department of Veterans Affairs (VA) Rehabilitation Research and Development Service (RR&D), National Center for Rehabilitative Auditory Research (NCRAR), VA Portland Health Care System , Portland, Oregon 97239, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn","family":"Konrad-Martin","sequence":"additional","affiliation":[{"name":"Department of Veterans Affairs (VA) Rehabilitation Research and Development Service (RR&D), National Center for Rehabilitative Auditory Research (NCRAR), VA Portland Health Care System , Portland, Oregon 97239, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"231","published-online":{"date-parts":[[2019,11,27]]},"reference":[{"key":"2023080210290018900_c1","doi-asserted-by":"publisher","first-page":"206","DOI":"10.3389\/fneur.2014.00206","article-title":"Central gain control in tinnitus and hyperacusis","volume":"5","year":"2014","journal-title":"Front. 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(2018). \u201c\nVeterans Benefits Administration annual benefits report fiscal year 2018,\u201d available at http:\/\/benefits.va.gov\/REPORTS\/abr\/ (Last viewed May 13, 2019)."},{"key":"2023080210290018900_c47","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.heares.2015.04.014","article-title":"Cochlear neuropathy in human presbycusis: Confocal analysis of hidden hearing loss in post-mortem tissue","volume":"327","year":"2015","journal-title":"Hear. Res."},{"key":"2023080210290018900_c48","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.heares.2011.04.004","article-title":"Inhibitory neurotransmission in animal models of tinnitus: Maladaptive plasticity","volume":"279","year":"2011","journal-title":"Hear. 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