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Many behavioral, anatomical, and physiological characteristics of the chinchilla make it a valuable animal model for hearing science. These include similarities with human hearing frequency and intensity sensitivity, the ability to be trained behaviorally with acoustic stimuli relevant to human hearing, a docile nature that allows many physiological measures to be made in an awake state, physiological robustness that allows for data to be collected from all levels of the auditory system, and the ability to model various types of conductive and sensorineural hearing losses that mimic pathologies observed in humans. Given these attributes, chinchillas have been used repeatedly to study anatomical, physiological, and behavioral effects of continuous and impulse noise exposures that produce either temporary or permanent threshold shifts. Based on the mechanistic insights from noise-exposure studies, chinchillas have also been used in pre-clinical drug studies for the prevention and rescue of noise-induced hearing loss. This review paper highlights the role of the chinchilla model in hearing science, its important contributions, and its advantages and limitations.<\/jats:p>","DOI":"10.1121\/1.5132950","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T16:30:59Z","timestamp":1574872259000},"page":"3710-3732","update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":53,"title":["The chinchilla animal model for hearing science and noise-induced hearing loss"],"prefix":"10.1121","volume":"146","author":[{"given":"Monica","family":"Trevino","sequence":"first","affiliation":[{"name":"School of Behavioral and Brain Sciences, Callier Center, The University of Texas at Dallas , 1966 Inwood Road, Dallas, Texas 75235, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Lobarinas","sequence":"additional","affiliation":[{"name":"School of Behavioral and Brain Sciences, Callier Center, The University of Texas at Dallas , 1966 Inwood Road, Dallas, Texas 75235, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda C.","family":"Maulden","sequence":"additional","affiliation":[{"name":"Department of Speech, Language, and Hearing Sciences, Purdue University , 715 Clinic Drive, West Lafayette, Indiana 47907, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Heinz","sequence":"additional","affiliation":[{"name":"Weldon School of Biomedical Engineering, Purdue University , 715 Clinic Drive, West Lafayette, Indiana 47907, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"231","published-online":{"date-parts":[[2019,11,27]]},"reference":[{"key":"2023080420185952800_c1","doi-asserted-by":"publisher","first-page":"244","DOI":"10.3109\/00206099309072940","article-title":"The role of tuning curve variables and threshold measures in the estimation of sensory cell loss","volume":"32","year":"1993","journal-title":"Audiology"},{"key":"2023080420185952800_c2","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/S0378-5955(98)00227-5","article-title":"Noise-induced hearing loss in the noise-toughened auditory system","volume":"129","year":"1999","journal-title":"Hear. 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