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Two interphase gaps (IPGs) were used for the biphasic pulses and the effect of the IPG on each ECAP measure was measured (\u201cIPG effect\u201d). When using a stimulus with a constant IPG, SGN density was related to the across-subject variance in ECAP AGF linear slope, peak amplitude, and N1 latency. The SGN density values also help to explain a significant proportion of variance in the IPG effect for AGF linear slope and peak amplitude measures. Regression modeling revealed that SGN density was the primary dependent variable contributing to across-subject variance for ECAP measures; SGN cell size did not significantly improve the fitting of the model. Results showed that simple impedance measures were weakly related to most ECAP measures but did not typically improve the fit of the regression model.<\/jats:p>","DOI":"10.1121\/10.0002882","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T13:10:59Z","timestamp":1608642659000},"page":"3900-3912","update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":30,"title":["How electrically evoked compound action potentials in chronically implanted guinea pigs relate to auditory nerve health and electrode impedance"],"prefix":"10.1121","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8194-6513","authenticated-orcid":false,"given":"Kara C.","family":"Schvartz-Leyzac","sequence":"first","affiliation":[{"name":"Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan , 1150 West Medical Center Drive, Ann Arbor, Michigan 48109-5616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah J.","family":"Colesa","sequence":"additional","affiliation":[{"name":"Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan , 1150 West Medical Center Drive, Ann Arbor, Michigan 48109-5616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Buswinka","sequence":"additional","affiliation":[{"name":"Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan , 1150 West Medical Center Drive, Ann Arbor, Michigan 48109-5616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Rabah","sequence":"additional","affiliation":[{"name":"Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan , 1150 West Medical Center Drive, Ann Arbor, Michigan 48109-5616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald L.","family":"Swiderski","sequence":"additional","affiliation":[{"name":"Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan , 1150 West Medical Center Drive, Ann Arbor, Michigan 48109-5616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehoash","family":"Raphael","sequence":"additional","affiliation":[{"name":"Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan , 1150 West Medical Center Drive, Ann Arbor, Michigan 48109-5616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan E.","family":"Pfingst","sequence":"additional","affiliation":[{"name":"Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan , 1150 West Medical Center Drive, Ann Arbor, Michigan 48109-5616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"231","published-online":{"date-parts":[[2020,12,22]]},"reference":[{"key":"2023080804364155600_c1","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1523\/JNEUROSCI.22-04-01385.2002","article-title":"Opposite actions of brain-derived neurotrophic factor and neurotrophin-3 on firing features and ion channel composition of murine spiral ganglion neurons","volume":"22","year":"2002","journal-title":"J. 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