{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:55:26Z","timestamp":1791046526571,"version":"4.1.0"},"reference-count":30,"publisher":"Acoustical Society of America (ASA)","issue":"12","license":[{"start":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T00:00:00Z","timestamp":1640822400000},"content-version":"vor","delay-in-days":29,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T00:00:00Z","timestamp":1640822400000},"content-version":"tdm","delay-in-days":29,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000084","name":"Directorate for Engineering","doi-asserted-by":"publisher","award":["1652632"],"award-info":[{"award-number":["1652632"]}],"id":[{"id":"10.13039\/100000084","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,12,1]]},"abstract":"<jats:p>A computational framework is proposed for virtual optimization of implant configurations of type 1 thyroplasty based on patient-specific laryngeal structures reconstructed from MRI images. Through integration of a muscle mechanics-based laryngeal posturing model, a flow-structure-acoustics interaction voice production model, a real-coded genetic algorithm, and virtual implant insertion, the framework acquires the implant configuration that achieves the optimal acoustic objectives. The framework is showcased by successfully optimizing an implant that restores acoustic features of a diseased voice resulted from unilateral vocal fold paralysis (UVFP) in producing a sustained vowel utterance. The sound intensity is improved from 62 dB (UVFP) to 81 dB (post-correction).<\/jats:p>","DOI":"10.1121\/10.0009084","type":"journal-article","created":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T12:37:08Z","timestamp":1640867828000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["A computational framework for patient-specific surgical planning of type 1 thyroplasty"],"prefix":"10.1121","volume":"1","author":[{"given":"Mohammadreza","family":"Movahhedi","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering, University of Maine , Orono, Maine 04473, USA \u2008 mohammadreza.movahhedi@maine.edu , biao.geng@maine.edu , qian.xue@maine.edu , xudong.zheng@maine.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, University of Maine , Orono, Maine 04473, USA \u2008 mohammadreza.movahhedi@maine.edu , biao.geng@maine.edu , qian.xue@maine.edu , xudong.zheng@maine.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, University of Maine , Orono, Maine 04473, USA \u2008 mohammadreza.movahhedi@maine.edu , biao.geng@maine.edu , qian.xue@maine.edu , xudong.zheng@maine.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, University of Maine , Orono, Maine 04473, USA \u2008 mohammadreza.movahhedi@maine.edu , biao.geng@maine.edu , qian.xue@maine.edu , xudong.zheng@maine.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"231","published-online":{"date-parts":[[2021,12,30]]},"reference":[{"key":"2023062704354156500_c1","doi-asserted-by":"publisher","first-page":"465","DOI":"10.3109\/00016487509121353","article-title":"Thyroplasty type I (lateral compression) for dysphonia due to vocal cord paralysis or atrophy","volume":"80","year":"1975","journal-title":"Acta Oto-Laryngol."},{"key":"2023062704354156500_c2","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1067\/S0892-1997(03)00080-8","article-title":"Thyroplasty revisions: Frequency and predictive factors","volume":"17","year":"2003","journal-title":"J. Voice"},{"key":"2023062704354156500_c3","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1097\/00005537-199811000-00020","article-title":"Complications of phonosurgery: Results of a national survey","volume":"108","year":"1998","journal-title":"Laryngoscope"},{"key":"2023062704354156500_c4","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1002\/lio2.322","article-title":"Effects of thyroplasty implant stiffness on glottal shape and voice acoustics","volume":"5","year":"2020","journal-title":"Laryngoscope Investig. Otolaryngol."},{"key":"2023062704354156500_c5","doi-asserted-by":"publisher","first-page":"2192","DOI":"10.1002\/lary.28365","article-title":"Effect of vocal fold implant placement on depth of vibration and vocal output","volume":"130","year":"2020","journal-title":"Laryngoscope"},{"key":"2023062704354156500_c6","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.jvoice.2014.07.003","article-title":"Effects of implant stiffness, shape, and medialization depth on the acoustic outcomes of medialization laryngoplasty","volume":"29","year":"2015","journal-title":"J. Voice"},{"key":"2023062704354156500_c7","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1121\/10.0005275","article-title":"Effects of cricothyroid and thyroarytenoid interaction on voice control: Muscle activity, vocal fold biomechanics, flow, and acoustics","volume":"150","year":"2021","journal-title":"J. Acoust. Soc. Am."},{"key":"2023062704354156500_c8","doi-asserted-by":"publisher","first-page":"4190","DOI":"10.1121\/1.5134784","article-title":"Voice production in a MRI-based subject-specific vocal fold model with parametrically controlled medial surface shape","volume":"146","year":"2019","journal-title":"J. Acoust. Soc. Am."},{"key":"2023062704354156500_c9","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.jvoice.2011.03.012","article-title":"A new method of reconstructing the human laryngeal architecture using micro-MRI","volume":"26","year":"2012","journal-title":"J. Voice"},{"key":"2023062704354156500_c10","doi-asserted-by":"publisher","first-page":"2597","DOI":"10.1121\/10.0001093","article-title":"A three-dimensional vocal fold posturing model based on muscle mechanics and magnetic resonance imaging of a canine larynx","volume":"147","year":"2020","journal-title":"J. Acoust. Soc. Am."},{"key":"2023062704354156500_c11","article-title":"Physiologically-based speech simulation using an enhanced wave-reflection model of the vocal tract"},{"key":"2023062704354156500_c12","volume-title":"Vocal Fold Paralysis","year":"2006"},{"key":"2023062704354156500_c13","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1044\/jshr.1403.544","article-title":"Subglottal pressure and airflow measures during vocal fry phonation","volume":"14","year":"1971","journal-title":"J. Speech Hear. Res."},{"key":"2023062704354156500_c14","doi-asserted-by":"publisher","first-page":"3231","DOI":"10.1121\/1.1869752","article-title":"A parametric model of the vocal tract area function for vowel and consonant simulation","volume":"117","year":"2005","journal-title":"J. Acoust. Soc. Am."},{"key":"2023062704354156500_c15","doi-asserted-by":"publisher","first-page":"5926","DOI":"10.1016\/j.cma.2005.09.017","article-title":"Two-dimensional optimization of material composition of functionally graded materials using meshless analyses and a genetic algorithm","volume":"195","year":"2006","journal-title":"Comput. Methods Appl. Mech. Eng."},{"key":"2023062704354156500_c16","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1177\/000348940111000305","article-title":"Objective voice analysis after autologous fat injection for unilateral vocal fold paralysis","volume":"110","year":"2001","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"2023062704354156500_c17","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/S0194-5998(00)70002-7","article-title":"Mechanical and dynamic aspects of voice production as related to voice therapy and phonosurgery","volume":"122","year":"2000","journal-title":"Head Neck Surg."},{"key":"2023062704354156500_c18","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1002\/(SICI)1097-0347(199901)21:1&lt;52::AID-HED7&gt;3.0.CO;2-H","article-title":"Arytenoid adduction as an adjunct to type I thyroplasty for unilateral vocal cord paralysis","volume":"21","year":"1999","journal-title":"Head Neck"},{"key":"2023062704354156500_c19","article-title":"Praat: Doing phonetics by computer (version 6.0.37) [computer program]","year":"2018"},{"key":"2023062704354156500_c20","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/S0892-1997(01)00037-6","article-title":"Objective voice quality analysis before and after onset of unilateral vocal fold paralysis","volume":"15","year":"2001","journal-title":"J. Voice"},{"key":"2023062704354156500_c21","doi-asserted-by":"publisher","first-page":"182","DOI":"10.3109\/14015439.2012.731083","article-title":"Vocal fold vibration amplitude, open quotient, speed quotient and their variability along glottal length: Kymographic data from normal subjects","volume":"38","year":"2013","journal-title":"Logop. Phoniatr. Vocol."},{"key":"2023062704354156500_c22","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1097\/00005537-200206000-00020","article-title":"High-precision measurement of the vocal fold length and vibratory amplitudes","volume":"112","year":"2002","journal-title":"Laryngoscope"},{"key":"2023062704354156500_c23","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1097\/00005537-200007000-00004","article-title":"Effects of thyroplasty type I on vocal fold vibration","volume":"110","year":"2000","journal-title":"Laryngoscope"},{"key":"2023062704354156500_c24","first-page":"1035","article-title":"A statistical analysis of melody curves in the intonation of Americal English","year":"2017"},{"key":"2023062704354156500_c25","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1002\/lary.20165","article-title":"Phonation threshold flow measurements in normal and pathological phonation","volume":"119","year":"2009","journal-title":"Laryngoscope"},{"key":"2023062704354156500_c26","article-title":"On the interdependencies between voice quality, glottal gaps, and voice-source related acoustic measures","year":"2010"},{"issue":"3","key":"2023062704354156500_c27","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.jvoice.2019.11.015","article-title":"Effects of vocal intensity and fundamental frequency on cepstral peak prominence in patients with voice disorders and vocally healthy controls","volume":"35","year":"2019","journal-title":"J. Voice"},{"key":"2023062704354156500_c28","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1016\/j.protcy.2014.10.138","article-title":"Jitter, shimmer and HNR classification within gender, tones and vowels in healthy voices","volume":"16","year":"2014","journal-title":"Proc. Technol."},{"key":"2023062704354156500_c29","doi-asserted-by":"publisher","first-page":"e0228464","DOI":"10.1371\/journal.pone.0228464","article-title":"Three-dimensional vocal fold structural change due to implant insertion in medialization laryngoplasty","volume":"15","year":"2020","journal-title":"PLoS One"},{"key":"2023062704354156500_c30","first-page":"78","volume-title":"Functional Histoanatomy of the Human Larynx","year":"2018"}],"container-title":["JASA Express Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.aip.org\/asa\/jel\/article-pdf\/doi\/10.1121\/10.0009084\/13588490\/125203_1_online.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pubs.aip.org\/asa\/jel\/article-pdf\/doi\/10.1121\/10.0009084\/13588490\/125203_1_online.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.aip.org\/asa\/jel\/article-pdf\/doi\/10.1121\/10.0009084\/13588490\/125203_1_online.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T14:33:43Z","timestamp":1746801223000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.aip.org\/jel\/article\/1\/12\/125203\/219461\/A-computational-framework-for-patient-specific"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,1]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12,1]]}},"URL":"https:\/\/doi.org\/10.1121\/10.0009084","relation":{},"ISSN":["2691-1191"],"issn-type":[{"value":"2691-1191","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,12]]},"published":{"date-parts":[[2021,12,1]]},"article-number":"125203"}}