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Despite the profound impact of hyperacusis on quality of life, clinicians and researchers lack objective biomarkers and standardized protocols for its assessment. Outcomes of conventional audiologic tests are highly variable in the hyperacusis population and do not adequately capture the multifaceted nature of the condition on an individual level. This presents challenges for the differential diagnosis of hyperacusis, its clinical surveillance, and evaluation of new treatment options. Multiple behavioral and objective assays are emerging as contenders for inclusion in hyperacusis assessment protocols but most still await rigorous validation. There remains a pressing need to develop tools to quantify common nonauditory symptoms, including annoyance, fear, and pain. This review describes the current literature on clinical and investigational tools that have been used to diagnose and monitor hyperacusis, as well as those that hold promise for inclusion in future trials. <\/jats:p>","DOI":"10.1121\/10.0012684","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T11:47:20Z","timestamp":1658404040000},"page":"553-566","update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["Clinical and investigational tools for monitoring noise-induced\n            hyperacusis"],"prefix":"10.1121","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5832-5137","authenticated-orcid":false,"given":"Kelly N.","family":"Jahn","sequence":"first","affiliation":[{"name":"Department of Speech, Language, and Hearing, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas 75080,\r            USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"231","reference":[{"key":"c1\/c1_1","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0000000000000982"},{"key":"c2\/c2_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1780-4002"},{"key":"c3\/c3_1","doi-asserted-by":"publisher","DOI":"10.4103\/nah.NAH_2_18"},{"key":"c4\/c4_1","doi-asserted-by":"publisher","DOI":"10.1080\/14992027.2017.1335888"},{"key":"c5\/c5_1","doi-asserted-by":"publisher","DOI":"10.1080\/14992027.2017.1298850"},{"key":"c6\/c6_1","doi-asserted-by":"publisher","DOI":"10.1044\/2017_AJA-17-0011"},{"key":"c7\/c7_1","doi-asserted-by":"publisher","DOI":"10.3766\/jaaa.17015"},{"key":"c8\/c8_1","unstructured":"American Speech-Language-Hearing\n            Association (2018). \u201c Tinnitus and\n            hyperacusis,\u201d available at https:\/\/www.asha.org\/PRPSpecificTopic.aspx?folderid=8589942834&section=Assessment#Assessment_of_Hyperacusis\n          (Last viewed 17 March 2020)."},{"key":"c9\/c9_1","doi-asserted-by":"publisher","DOI":"10.1080\/010503999424653"},{"key":"c10\/c10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2020.108053"},{"key":"c11\/c11_1","doi-asserted-by":"publisher","DOI":"10.3109\/14992020209056075"},{"key":"c12\/c12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.543134"},{"key":"c13\/c13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04852-y"},{"key":"c14\/c14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(93)90026-W"},{"key":"c15\/c15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2014.00206"},{"key":"c16\/c16_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016488709107322"},{"key":"c17\/c17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00106-017-0464-3"},{"key":"c18\/c18_1","doi-asserted-by":"publisher","DOI":"10.3109\/14992027.2012.664290"},{"key":"c19\/c19_1","doi-asserted-by":"publisher","DOI":"10.3109\/14992021003724996"},{"key":"c20\/c20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2018.00149"},{"key":"c21\/c21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2019.02.016"},{"key":"c22\/c22_1","doi-asserted-by":"publisher","DOI":"10.1044\/2019_AJA-19-00060"},{"key":"c23\/c23_1","doi-asserted-by":"publisher","DOI":"10.1044\/1059-0889.0401.46"},{"key":"c24\/c24_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-06-02383.2002"},{"key":"c25\/c25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.12.041"},{"key":"c26\/c26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7967(85)90140-8"},{"key":"c27\/c27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-013-0375-2"},{"key":"c28\/c28_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/658741"},{"key":"c29\/c29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.12.005"},{"key":"c30\/c30_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.06576"},{"key":"c31\/c31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2020.108021"},{"key":"c32\/c32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003446-199710000-00004"},{"key":"c33\/c33_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480510027565"},{"key":"c34\/c34_1","doi-asserted-by":"publisher","DOI":"10.3766\/jaaa.17025"},{"key":"c35\/c35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2016.05.008"},{"key":"c36\/c36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2020.108124"},{"key":"c37\/c37_1","first-page":"569","volume-title":"Proceedings of the Sixth International Tinnitus Seminar","author":"Fabijanska A.","year":"1999"},{"key":"c38\/c38_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/290425"},{"key":"c39\/c39_1","first-page":"193","volume":"3","author":"Filion P. 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