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In this study, a fully coupled three-dimensional finite-element model of the mouse ear canal (EC), ME, and cochlea was used to calculate ME pressure gains, impedances, and reflectances at the EC-entrance and stapes-footplate\u2013cochlear-fluid interfaces. The cochlear model incorporates a series of interdigitated Y-shaped structures sandwiched between the basilar membrane and reticular lamina, each comprised of a Deiters' cell, its phalangeal-process extension, and an outer hair cell (OHC). By introducing random perturbations to the OHC gains, stimulation-frequency otoacoustic emissions (SFOAEs) were generated. Raising the perturbation magnitude from 10% to 80% increased the SFOAE magnitude by up to 24\u2009dB in the 10\u201330\u2009kHz frequency range. Increasing or decreasing the stiffness of the stapes annular ligament and eardrum by a factor of 8 changed the SFOAEs by up to 30\u2009dB, but the round-trip ME gain as measured could not account for this. A modified round-trip ME gain, with reflections removed at the EC-entrance and stapes\u2013cochlea boundaries, eliminated a \u00b110\u2009dB discrepancy and allowed ME changes to be quantitatively associated with changes in measured OAEs.<\/jats:p>","DOI":"10.1121\/10.0014901","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T13:33:27Z","timestamp":1667828007000},"page":"2769-2780","update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["Stimulus-frequency otoacoustic emissions and middle-ear pressure gains in a finite-element mouse model"],"prefix":"10.1121","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3390-5263","authenticated-orcid":false,"given":"Hamid","family":"Motallebzadeh","sequence":"first","affiliation":[{"name":"Eaton-Peabody Laboratories, Massachusetts Eye and Ear , Boston, Massachusetts 02114, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2810-3541","authenticated-orcid":false,"given":"Sunil","family":"Puria","sequence":"additional","affiliation":[{"name":"Eaton-Peabody Laboratories, Massachusetts Eye and Ear , Boston, Massachusetts 02114, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"231","published-online":{"date-parts":[[2022,11,7]]},"reference":[{"key":"2023081004342023900_c1","first-page":"44","article-title":"Measurement of eardrum acoustic impedance","volume-title":"Peripheral Auditory Mechanisms","year":"1986"},{"key":"2023081004342023900_c2","doi-asserted-by":"publisher","first-page":"13651","DOI":"10.1038\/s41598-021-93099-7","article-title":"Intracochlear distortion products are broadly generated by outer hair cells but their contributions to otoacoustic emissions are spatially restricted","volume":"11","year":"2021","journal-title":"Sci. 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