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Subject-related factors, including species, strain, age, sex, body weight, and post-exposure measurement timepoints, influence the observed hearing deficits. Experimenter effects, such as experience with experimental techniques and animal handling, may also factor into reported thresholds. In this study, the influence of subject sex, body mass, age at noise exposure, and timepoint of post-exposure recording are reported from a large sample of CBA\/CaJ mice. Auditory brainstem response (ABR) thresholds differed between noise-exposed and unexposed mice, although the differences varied across tone frequencies. Thresholds across age at noise exposures and measurement delays after exposure also differed for some timepoints. Higher body mass correlated with higher ABR thresholds for unexposed male and female mice, but not for noise-exposed mice. Together, these factors may contribute to differences in phenotypic outcomes observed across studies or even within a single laboratory.<\/jats:p>","DOI":"10.1121\/10.0016593","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T12:41:36Z","timestamp":1671108096000},"page":"3576-3582","update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Sources of variability in auditory brainstem response thresholds in a mouse model of noise-induced hearing loss"],"prefix":"10.1121","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9963-9642","authenticated-orcid":false,"given":"Katrina M.","family":"Schrode","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery and Center for Hearing and Balance, Johns Hopkins University School of Medicine 1 , 515 Traylor Building, 720 Rutland Avenue, Baltimore, Maryland 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7462-501X","authenticated-orcid":false,"given":"Micheal L.","family":"Dent","sequence":"additional","affiliation":[{"name":"Department of Psychology, B76 Park Hall, University at Buffalo-SUNY 2 , Buffalo, New York 14260, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4184-7374","authenticated-orcid":false,"given":"Amanda M.","family":"Lauer","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery and Center for Hearing and Balance, Johns Hopkins University School of Medicine 1 , 515 Traylor Building, 720 Rutland Avenue, Baltimore, Maryland 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"231","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"key":"2023081005310009000_c1","doi-asserted-by":"crossref","unstructured":"Bates, D., M\u00e4chler, M., Bolker, B., and Walker, S. 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