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This study presents a detailed biophysical model of the inner-hair cells embedded in an end-to-end computational model of the auditory pathway with an acoustic signal as an input and prediction of human audiometric thresholds as an output. The contribution of the outer hair cells is included in the mechanical model of the cochlea. Different types of HL were simulated by changing mechanical and biochemical parameters of the inner and outer hair cells. The predicted thresholds yielded common audiograms of hearing impairment. Outer hair cell damage could only introduce threshold shifts at mid-high frequencies up to 40\u2009dB. Inner hair cell damage affects low and high frequencies differently. All types of inner hair cell deficits yielded a maximum of 40\u2009dB HL at low frequencies. Only a significant reduction in the number of cilia of the inner-hair cells yielded HL of up to 120\u2009dB HL at high frequencies. Sloping audiograms can be explained by a combination of gradual change in the number of cilia of inner and outer hair cells along the cochlear partition from apex to base.<\/jats:p>","DOI":"10.1121\/10.0017627","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T15:04:52Z","timestamp":1679065492000},"page":"1776-1790","update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":7,"title":["Inner-hair-cell induced hearing loss: A biophysical modeling perspective"],"prefix":"10.1121","volume":"153","author":[{"given":"Michael","family":"Faran","sequence":"first","affiliation":[{"name":"School of Electrical Engineering, Faculty of Engineering, Tel-Aviv University , Tel-Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Furst","sequence":"additional","affiliation":[{"name":"School of Electrical Engineering, Faculty of Engineering, Tel-Aviv University , Tel-Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"231","published-online":{"date-parts":[[2023,3,17]]},"reference":[{"key":"2023072814152698200_c1","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1103\/PhysRev.53.832","article-title":"Statistical theory of a scaling circuit","volume":"53","year":"1938","journal-title":"Phys. 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