{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T16:28:08Z","timestamp":1772209688445,"version":"3.50.1"},"reference-count":33,"publisher":"Acoustical Society of America (ASA)","issue":"3","funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R01 DC11300"],"award-info":[{"award-number":["R01 DC11300"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DC11300"],"award-info":[{"award-number":["R01 DC11300"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:p>Phonatory instabilities and involuntary register transitions can occur during singing. However, little is known regarding the mechanisms which govern such transitions. To investigate this phenomenon, we systematically varied laryngeal muscle activation and airflow in an in vivo canine larynx model during phonation. We calculated voice range profiles showing average nerve activations for all combinations of fundamental frequency (F0) and sound pressure level (SPL). Further, we determined closed-quotient (CQ) and minimum-posterior-area (MPA) based on high-speed video recordings. While different combinations of muscle activation favored different combinations of F0 and SPL, in the investigated larynx there was a consistent region of instability at about 400\u2009Hz which essentially precluded phonation. An explanation for this region may be a larynx specific coupling between sound source and subglottal tract or an effect based purely on larynx morphology. Register transitions crossed this region, with different combinations of cricothyroid and thyroarytenoid muscle (TA) activation stabilizing higher or lower neighboring frequencies. Observed patterns in CQ and MPA dependent on TA activation reproduced patterns found in singers in previous work. Lack of control of TA stimulation may result in phonation instabilities, and enhanced control of TA stimulation may help to avoid involuntary register transitions, especially in the singing voice.<\/jats:p>","DOI":"10.1121\/10.0025135","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T16:24:09Z","timestamp":1710779049000},"page":"2139-2150","update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["Register transitions in an <i>in vivo<\/i> canine model as a function of intrinsic laryngeal muscle stimulation, fundamental frequency, and sound pressure level"],"prefix":"10.1121","volume":"155","author":[{"given":"Patrick","family":"Schlegel","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery, David Geffen School of Medicine at the University of California-Los Angeles , Los Angeles, California 90095, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Berry","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, David Geffen School of Medicine at the University of California-Los Angeles , Los Angeles, California 90095, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clare","family":"Moffatt","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, David Geffen School of Medicine at the University of California-Los Angeles , Los Angeles, California 90095, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2379-6086","authenticated-orcid":false,"given":"Zhaoyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, David Geffen School of Medicine at the University of California-Los Angeles , Los Angeles, California 90095, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinesh K.","family":"Chhetri","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, David Geffen School of Medicine at the University of California-Los Angeles , Los Angeles, California 90095, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"231","published-online":{"date-parts":[[2024,3,18]]},"reference":[{"key":"2024031913561124200_c1","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0892-1997(96)80039-7","article-title":"Bifurcations in excised larynx experiments","volume":"10","year":"1996","journal-title":"J. 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