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Rubenstein Fund for Hearing Research"},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["T32 DC000023"],"award-info":[{"award-number":["T32 DC000023"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:p>Medial olivocochlear (MOC) efferents modulate outer hair cell motility through specialized nicotinic acetylcholine receptors to support encoding of signals in noise. Transgenic mice lacking the alpha9 subunits of these receptors (\u03b19KOs) have normal hearing in quiet and noise, but lack classic cochlear suppression effects and show abnormal temporal, spectral, and spatial processing. Mice deficient for both the alpha9 and alpha10 receptor subunits (\u03b19\u03b110KOs) may exhibit more severe MOC-related phenotypes. Like \u03b19KOs, \u03b19\u03b110KOs have normal auditory brainstem response (ABR) thresholds and weak MOC reflexes. Here, we further characterized auditory function in \u03b19\u03b110KO mice. Wild-type (WT) and \u03b19\u03b110KO mice had similar ABR thresholds and acoustic startle response amplitudes in quiet and noise, and similar frequency and intensity difference sensitivity. \u03b19\u03b110KO mice had larger ABR Wave I amplitudes than WTs in quiet and noise. Other ABR metrics of hearing-in-noise function yielded conflicting findings regarding \u03b19\u03b110KO susceptibility to masking effects. \u03b19\u03b110KO mice also had larger startle amplitudes in tone backgrounds than WTs. Overall, \u03b19\u03b110KO mice had grossly normal auditory function in quiet and noise, although their larger ABR amplitudes and hyperreactive startles suggest some auditory processing abnormalities. These findings contribute to the growing literature showing mixed effects of MOC dysfunction on hearing.<\/jats:p>","DOI":"10.1121\/10.0025985","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T08:16:26Z","timestamp":1715588186000},"page":"3183-3194","update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":7,"title":["Alpha9alpha10 knockout mice show altered physiological and behavioral responses to signals in masking noise"],"prefix":"10.1121","volume":"155","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3256-6984","authenticated-orcid":false,"given":"Jane A.","family":"Mondul","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Johns Hopkins University School of Medicine 1 , Baltimore, Maryland 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1736-480X","authenticated-orcid":false,"given":"Kali","family":"Burke","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Johns Hopkins University School of Medicine 1 , Baltimore, Maryland 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Morley","sequence":"additional","affiliation":[{"name":"Boys Town National Research Hospital 2 , Omaha, Nebraska 68131, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4184-7374","authenticated-orcid":false,"given":"Amanda M.","family":"Lauer","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Johns Hopkins University School of Medicine 1 , Baltimore, Maryland 21205, USA"},{"name":"Department of Neuroscience, Johns Hopkins University School of Medicine 3 , Baltimore, Maryland 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"231","published-online":{"date-parts":[[2024,5,13]]},"reference":[{"key":"2024051312142229300_c1","doi-asserted-by":"publisher","first-page":"361","DOI":"10.3389\/fncel.2017.00361","article-title":"Reflex modification audiometry reveals dual roles for olivocochlear neurotransmission","volume":"11","year":"2017","journal-title":"Front. 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