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The auditory preprocessing component effectively captures advanced physiological details of the auditory system, such as retrograde traveling waves, longitudinal coupling, and cochlear nonlinearity. The ability of the model to predict data from normal-hearing listeners under various additive noise conditions was considered. The predictions closely matched the experimental test data under all conditions. Furthermore, we developed a lumped mass model of a McGee stainless-steel piston with the middle-ear to study the recovery of individuals with otosclerosis. We show that the proposed SI model accurately simulates the effect of middle-ear intervention on SI. Consequently, the model establishes a model-based relationship between objective measures of human ear damage, like distortion product otoacoustic emissions, and speech perception. Moreover, the SI model can serve as a robust tool for optimizing parameters and for preoperative assessment of artificial stimuli, providing a valuable reference for clinical treatments of conductive hearing loss.<\/jats:p>","DOI":"10.1121\/10.0028584","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T12:11:07Z","timestamp":1725883867000},"page":"1609-1622","update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["Speech intelligibility prediction based on a physiological model of the human ear and a hierarchical spiking neural network"],"prefix":"10.1121","volume":"156","author":[{"given":"Yinxin","family":"Kou","sequence":"first","affiliation":[{"name":"School of Mechatronic Engineering, China University of Mining and Technology 1 , Xuzhou 221116, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5450-5958","authenticated-orcid":false,"given":"Houguang","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Mechatronic Engineering, China University of Mining and Technology 1 , Xuzhou 221116, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Otorhinolaryngology-Head & Neck Surgery, Ministry of Education, Beijing Tongren Hospital Affiliated to Capital Medical University 2 , Beijing 100730, China"},{"name":"Beijing Engineering Research Center of Hearing Technology 3 , Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital 4 , Beijing 100853, China"},{"name":"Key Lab of Hearing Science, Ministry of Education 5 , Beijing 100853, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5389-9142","authenticated-orcid":false,"given":"Jianhua","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Mechatronic Engineering, China University of Mining and Technology 1 , Xuzhou 221116, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanguo","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Mechatronic Engineering, China University of Mining and Technology 1 , Xuzhou 221116, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"231","published-online":{"date-parts":[[2024,9,9]]},"reference":[{"key":"2024090912085779200_c1","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1093\/eurpub\/ckr176","article-title":"Global and regional hearing impairment prevalence: An analysis of 42 studies in 29 countries","volume":"23","year":"2013","journal-title":"Eur. 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