{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:49:20Z","timestamp":1787237360898,"version":"build-2736575974"},"reference-count":66,"publisher":"Acoustical Society of America (ASA)","issue":"3","funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["MOST 108\u20132320-B-227-001-MY2"],"award-info":[{"award-number":["MOST 108\u20132320-B-227-001-MY2"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,3,1]]},"abstract":"<jats:p>Tinnitus is considered a potential consequence of cochlear synaptopathy. While animal studies have shown that this neural deafferentation reduces wave I amplitudes of the auditory brainstem response (ABR) at suprathreshold levels, studies in humans with tinnitus have reported conflicting results. To enhance the sensitivity of ABRs in detecting neurophysiological conditions associated with tinnitus, this study aimed to examine chirp-evoked ABRs in normal-hearing individuals with tinnitus using the maximum length sequence (MLS) technique. Chirp stimuli improve synchronous neural discharge during ABR recording, while the MLS technique enables the extraction of evoked responses from overlapping waveforms. We hypothesized that this combined approach would more effectively reveal ABR morphological characteristics associated with tinnitus. The results indicated no significant difference in noise exposure between the tinnitus and control groups. However, the tinnitus group exhibited significantly larger wave I amplitude, prolonged wave V latency, and extended interpeak interval in MLS responses to chirps at the lowest stimulus rate of 13.8\/s. These findings identify unique characteristics of MLS responses to chirps in individuals with tinnitus. We interpret our findings in relation to the ongoing discussion about the neurophysiological mechanisms of tinnitus. Further studies should be conducted to investigate possible etiologies of tinnitus.<\/jats:p>","DOI":"10.1121\/10.0036241","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T08:25:56Z","timestamp":1742977556000},"page":"2180-2190","update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["Impact of tinnitus on chirp-evoked auditory brainstem response recorded using maximum length sequences"],"prefix":"10.1121","volume":"157","author":[{"given":"Hsiang-Hung","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Speech-Language Pathology and Audiology, National Taipei University of Nursing and Health Sciences 1 , Number 365, Mingde Road, Beitou District, Taipei City, 112303,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3034-3963","authenticated-orcid":false,"given":"Yu-Fu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Speech-Language Pathology and Audiology, National Taipei University of Nursing and Health Sciences 1 , Number 365, Mingde Road, Beitou District, Taipei City, 112303,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzong-Hann","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Taipei City Hospital 2 , Number 145, Zhengzhou Road, Datong District, Taipei City, 103212,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pey-Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, MacKay Memorial Hospital 3 , Number 92, Section 2, Zhongshan North Road, Zhongshan Distict, Taipei City, 104217,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju-Han","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Nursing, National Taipei University of Nursing and Health Sciences 4 , Number 365, Mingde Road, Beitou District, Taipei City, 112303,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tun-Shin","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Speech Language Pathology and Audiology, Chung Shan Medical University 5 , Number 110, Section 1, Jianguo North Road, Taichung City, 402306,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Fu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Taipei Veterans General Hospital 6 , Number 201, Section 2, Shipai Road, Beitou District, Taipei City, 112201,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"231","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"key":"2025032711320486300_c1","doi-asserted-by":"publisher","first-page":"206","DOI":"10.3389\/fneur.2014.00206","article-title":"Central gain control in tinnitus and hyperacusis","volume":"5","year":"2014","journal-title":"Front. 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