{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:07:44Z","timestamp":1771459664491,"version":"3.50.1"},"reference-count":0,"publisher":"Human Kinetics","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:p>The aim of our study was to investigate the relationship between objectively measured physical activity (PA) and cardiorespiratory fitness (CRF) and serum metabolites measured by targeted metabolomics in a population- based study. A total of 100 subjects provided 2 fasting blood samples and engaged in a CRF and PA measurement at 2 visits 4 months apart. CRF was estimated from a step test, whereas physical activity energy expenditure (PAEE), time spent sedentary and time spend in vigorous activity were measured by a combined heart rate and movement sensor for a total of 8 days. Serum metabolite concentrations were determined by flow injection analysis tandem mass spectrometry (FIA-MS\/MS). Linear mixed models were applied with multivariable adjustment and <jats:italic>p<\/jats:italic>-values were corrected for multiple testing. Furthermore, we explored the associations between CRF, PA and two metabolite factors that have previously been linked to risk of Type 2 diabetes. CRF was associated with two phosphatidylcholine clusters independently of all other exposures. Lysophosphatidylcholine C14:0 and methionine were significantly negatively associated with PAEE and sedentary time. CRF was positively associated with the Type 2 diabetes protective factor. Vigorous activity was positively associated with the Type 2 diabetes risk factor in the mutually adjusted model. Our results suggest that CRF and PA are associated with serum metabolites, especially CRF with phosphatidylcholines and with the Type 2 diabetes protective factor. PAEE and sedentary time were associated with methionine. The identified metabolites could be potential mediators of the protective effects of CRF and PA on chronic disease risk.<\/jats:p>","DOI":"10.1123\/ijsnem.2013-0048","type":"journal-article","created":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T16:26:37Z","timestamp":1399393597000},"page":"215-226","source":"Crossref","is-referenced-by-count":20,"title":["Serum Metabolites Related to Cardiorespiratory Fitness, Physical Activity Energy Expenditure, Sedentary Time and Vigorous Activity"],"prefix":"10.1123","volume":"24","author":[{"given":"Angelika","family":"Wientzek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Floegel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Kn\u00fcppel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthaeus","family":"Vigl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagmar","family":"Drogan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerzy","family":"Adamski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Pischon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heiner","family":"Boeing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"100","container-title":["International Journal of Sport Nutrition and Exercise Metabolism"],"original-title":[],"link":[{"URL":"https:\/\/journals.humankinetics.com\/view\/journals\/ijsnem\/24\/2\/article-p215.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.humankinetics.com\/downloadpdf\/journals\/ijsnem\/24\/2\/article-p215.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.humankinetics.com\/downloadpdf\/journals\/ijsnem\/24\/2\/article-p215.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T02:55:06Z","timestamp":1724295306000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.humankinetics.com\/view\/journals\/ijsnem\/24\/2\/article-p215.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1123\/ijsnem.2013-0048","relation":{},"ISSN":["1526-484X","1543-2742"],"issn-type":[{"value":"1526-484X","type":"print"},{"value":"1543-2742","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4]]}}}