{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:31:44Z","timestamp":1761895904367},"reference-count":0,"publisher":"Human Kinetics","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p>Omega-3 fatty acids exert a plethora of physiological actions including triglycerides lowering, reduction of inflammatory indices, immunomodulation, anti- thrombotic effects and possibly promotion of exercise performance. Their use is widespread and for commonly ingested doses their side- effects are minimal. We report a case of a 60y amateur athlete who consumed about 20 g omega-3 fatty acids daily from supplements and natural sources for a year. After the intake of cortisone and antibiotics he presented duodenum ulcer and bleeding although he had no previous history of gastrointestinal problems. Although several animal data support gastro-protective effects of omega-3 fatty acids in the present case they were not able to prevent ulcer generation. The present observation may be explained by (i) the high dose of omega-3 fatty acids and their effect on bleeding, (ii) the fact that cortisone increases their oxidation and may render them proinflammatory, (iii) other antithrombotic microconstituents included in the consumed cod-oil and\/or the diet of the subject and (iv) the differences in the coagulation and fibrinolytic systems of well- trained subjects. Further studies are needed to substantiate any possible interaction of cortisone and omega-3 fatty acids in wide ranges of intake.<\/jats:p>","DOI":"10.1123\/ijsnem.2013-0204","type":"journal-article","created":{"date-parts":[[2014,6,23]],"date-time":"2014-06-23T19:16:13Z","timestamp":1403550973000},"page":"253-257","source":"Crossref","is-referenced-by-count":11,"title":["Gastrointestinal Bleeding After High Intake of Omega-3 Fatty Acids, Cortisone and Antibiotic Therapy: A Case Study"],"prefix":"10.1123","volume":"24","author":[{"given":"Paraskevi","family":"Detopoulou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasilios","family":"Papamikos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"100","container-title":["International Journal of Sport Nutrition and Exercise Metabolism"],"original-title":[],"link":[{"URL":"https:\/\/journals.humankinetics.com\/view\/journals\/ijsnem\/24\/3\/article-p253.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.humankinetics.com\/downloadpdf\/journals\/ijsnem\/24\/3\/article-p253.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.humankinetics.com\/downloadpdf\/journals\/ijsnem\/24\/3\/article-p253.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T02:53:51Z","timestamp":1724295231000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.humankinetics.com\/view\/journals\/ijsnem\/24\/3\/article-p253.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1123\/ijsnem.2013-0204","relation":{},"ISSN":["1526-484X","1543-2742"],"issn-type":[{"type":"print","value":"1526-484X"},{"type":"electronic","value":"1543-2742"}],"subject":[],"published":{"date-parts":[[2014,6]]}}}