{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:05:49Z","timestamp":1724371549685},"reference-count":40,"publisher":"Human Kinetics","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:p>The effects of acute consumption of <jats:sc>L<\/jats:sc>-Arginine (<jats:sc>L<\/jats:sc>-Arg) in healthy young individuals are not clearly defined, and no studies on the effects of <jats:sc>L<\/jats:sc>-Arg in individuals with abnormal body mass index undertaking strenuous exercise exist. Thus, we examined whether supplementation with <jats:sc>L<\/jats:sc>-Arg diminishes cardiopulmonary exercise testing responses, such as ventilation (VE), VE\/VCO<jats:sub>2<\/jats:sub>, oxygen uptake (VO<jats:sub>2<\/jats:sub>), and heart rate, in response to an acute session of high-intensity interval exercise (HIIE) in overweight men. A double-blind, randomized crossover design was used to study 30 overweight men (age, 26.5\u2009\u00b1\u20092.2\u00a0years; body weight, 88.2\u2009\u00b1\u20095.3\u00a0kilogram; body mass index, 28.0\u2009\u00b1\u20091.4\u00a0kg\/m<jats:sup>2<\/jats:sup>). Participants first completed a ramped-treadmill exercise protocol to determine VO<jats:sub>2<\/jats:sub>max velocity (vVO<jats:sub>2<\/jats:sub>max), after which they participated in two sessions of HIIE. Participants were randomly assigned to receive either 6\u00a0g of <jats:sc>L<\/jats:sc>-Arg or placebo supplements. The HIIE treadmill running protocol consisted of 12 trials, including exercise at 100% of vVO<jats:sub>2<\/jats:sub>max for 1\u00a0min interspersed with recovery intervals of 40% of vVO<jats:sub>2<\/jats:sub>max for 2\u00a0min. Measurements of VO<jats:sub>2<\/jats:sub> (ml\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup>), VE (L\/min), heart rate (beat per min), and VE\/VCO<jats:sub>2<\/jats:sub> were obtained. Supplementation with <jats:sc>L<\/jats:sc>-Arg significantly decreased all cardiorespiratory responses during HIIE (placebo+HIIE vs. <jats:sc>L<\/jats:sc>-Arg+HIIE for each measurement: VE [80.9\u2009\u00b1\u20094.3\u00a0L\/min vs. 74.6\u2009\u00b1\u20093.5\u00a0L\/min, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05, ES\u2009=\u20091.61], VE\/VCO<jats:sub>2<\/jats:sub> [26.4\u2009\u00b1\u20091.3 vs. 24.4\u2009\u00b1\u20091.0, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05, ES\u2009=\u20091.8], VO<jats:sub>2<\/jats:sub> [26.4\u2009\u00b1\u20090.8\u00a0ml\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup> vs. 24.4\u2009\u00b1\u20090.9\u00a0ml\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05, ES\u2009=\u20092.2], and heart rate [159.7\u2009\u00b1\u20096.3\u00a0beats\/min vs. 155.0\u2009\u00b1\u20093.7\u00a0beats\/min, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05, <jats:italic>d<\/jats:italic>\u2009=\u20090.89]). The authors conclude consuming <jats:sc>L<\/jats:sc>-Arg before HIIE can alleviate the excessive physiological strain resulting from HIIE and help to increase exercise tolerance in participants with a higher body mass index who may need to exercise on a regular basis for extended periods to improve their health.<\/jats:p>","DOI":"10.1123\/ijsnem.2020-0054","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T15:26:55Z","timestamp":1606836415000},"page":"46-54","source":"Crossref","is-referenced-by-count":0,"title":["L-Arginine Improves Endurance to High-Intensity Interval Exercises in Overweight Men"],"prefix":"10.1123","volume":"31","author":[{"given":"Ali","family":"Daraei","sequence":"first","affiliation":[{"name":"Shahid Beheshti University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sajad","family":"Ahmadizad","sequence":"additional","affiliation":[{"name":"Shahid Beheshti University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiwa","family":"Rahmani","sequence":"additional","affiliation":[{"name":"Shahid Beheshti University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony C.","family":"Hackney","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly E.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Coastal Carolina University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismail","family":"Laher","sequence":"additional","affiliation":[{"name":"University of British Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayoub","family":"Saeidi","sequence":"additional","affiliation":[{"name":"Islamic Azad University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassane","family":"Zouhal","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Rennes 2"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"100","reference":[{"issue":"1","key":"r1","series-title":"Applied Physiology, Nutrition, and Metabolism,","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1139\/h11-144","article-title":"Acute L-arginine supplementation increases muscle blood volume but not strength performance","volume":"37","author":"\u00c1lvares, T.S.","year":"2012","unstructured":"\u00c1lvares, T.S., Conte, C.A., Jr., Paschoalin, V.M.F., Silva, J.T., Meirelles, C.D.M., Bhambhani, Y.N., & Gomes, P.S.C. 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